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Reposted by Pedro Beltrao

The Francis Crick Institute @crick.ac.uk · 18h

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Pedro Beltrao @pedrobeltrao.bsky.social · 18h

Thanks. We didn't really use any tissue specific information. It would be interesting to explore tissue specific differences at some point too.

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Reposted by Pedro Beltrao

Jörg Vogel @jorg-vogel-lab.bsky.social · 1d

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

This has been the work of many people in many labs, including several of our previous lab members. Our main PTM focus has always been phosphorylation but multiple lab members looked at ubi as a side-project application over the years.

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

Finally, we tested some examples by mutations in conserved sites and most excitingly, @klanglab.bsky.social 's lab used their new method of in vitro site-specific mono-ubiquitination to show that mono ubi ELAVL1 disrupts binding to RNA

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

Julian built a ML model combining data on evolution, regulation, structures and MS evidence to predict "regulatory" sites. The model does well and suggests mechanisms for patient mutations. We tried to dig into some regulatory functions (activity, localization) in the manuscript

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

We compiled a large dataset of 100 experiments where changes in ubiquitination were measured after perturbations. One really interesting finding from this was that highly conserved sites seem less linked with protein degradation and more with other signalling functions.

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

Eric Bennett's lab (UCSD) generated ubi data in different species that we combined with public data. While not many ubi-sites are highly conserved, these tend to be enriched in annotated functions. We find regulatory hotspot regions in domain families indicative of ancient regulation.

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

We first needed a reliable catalog of ubiquitination sites (ubi-sites). Andy Jones's lab and Juan Antonio Vizcaino's @pride-ebi.bsky.social team reprocessed 11 datasets to derive 108,431 ubi-sites with controlled FDR. We then studied their conservation and regulation across conditions.

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

The functional landscape of the human ubiquitinome

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

www.biorxiv.org

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Pedro Beltrao @pedrobeltrao.bsky.social · 1d

Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.

protaiomics.bsky.social @protaiomics.bsky.social · 1d

🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

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Reposted by Pedro Beltrao

Claudia Bank @cbank.bsky.social · 2d

Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩‍🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED

Uni Bern: Assistant Professor with tenure-track for Quantitative Cell Biology

Start date of employment: anticipated for August 2027

ohws.prospective.ch

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Reposted by Pedro Beltrao

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 3d

2025 Nobel Prize in Physiology or Medicine #nobelprize

E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

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Reposted by Pedro Beltrao

Wolfgang Huber @wkhuber.bsky.social · 6d

(Huber lab)[EMBL] welcomes applications for a PhD in ML for spatial omics [representation learning + integration with biostatistics, cell + anatomy foundation models, collaborate with domain scientists on cancer and dev:bio discovery science] |> Apply though the ELLIS portal ::: Deadline 2025-10-31

ELLIS @ellis.eu · 8d

🎓 The application portal for the #ELLISPhD Program is open today! Info & link: https://bit.ly/45DSe75

ELLIS PhD Program: Call for Applications 2025

The ELLIS mission is to create a diverse European network that promotes research excellence and advances breakthroughs in AI, as well as a pan-European PhD program to educate the next generation of AI...

ellis.eu

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Pedro Beltrao @pedrobeltrao.bsky.social · 6d

I am going to take next year off from traveling to conferences (unless I can do a day trip). I might try to find some other way to "present" our group's work or otherwise engage more online with other scientists.

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Reposted by Pedro Beltrao

Gonzalo Parra @gonzaparra.bsky.social · 8d

🚀 As first official act, we are hiring! 🎓
We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded!

More information here:
www.bsc.es/join-us/job-...

Gonzalo Parra @gonzaparra.bsky.social · 8d

After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx

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Reposted by Pedro Beltrao

protaiomics.bsky.social @protaiomics.bsky.social · 7d

🌟 Great Opportunity!
The ProtAIomics Doctoral Network (ProtAIomics-DN) is launching soon!

💡 We are offering 16 fully funded PhD positions to shape the future of AI-driven proteomics research.

👉 Stay tuned for updates!
#PhD #Proteomics #ArtificialIntelligence #MSCA #HorizonEurope #PhDOpportunities

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Reposted by Pedro Beltrao

Mcclelland lab @mcclellandlab.bsky.social · 9d

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

Professors x 10, Faculty of Medicine & Dentistry | Veredus

QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...

www.veredus.co.uk

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Reposted by Pedro Beltrao

Tina Perica @glukozica.bsky.social · 11d

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 13d

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

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Reposted by Pedro Beltrao

Cancer Research UK Manchester Institute @cruk-mi.bsky.social · 15d

Exciting news - we are recruiting new Group Leaders! 🥼

We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes

Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Group Leader Recruitment at the Cancer Research UK Manchester Institute

YouTube video by CRUK Manchester Institute

youtu.be

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Reposted by Pedro Beltrao

Arnau Sebé-Pedrós @arnausebe.bsky.social · 15d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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Reposted by Pedro Beltrao

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 24d

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

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Reposted by Pedro Beltrao

Josh T Cuperus @rnanerd.bsky.social · 16d

www.biorxiv.org/content/10.1...

Dosa: A method to covalently barcode proteins for high throughput biochemistry

Deep mutational scanning couples a proteins activity to DNA sequencing for high throughput assessment of the effects of all single amino acid substitutions, but it largely uses indirect assays, like g...

www.biorxiv.org

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Reposted by Pedro Beltrao

Yun S. Song @yun-s-song.bsky.social · 18d

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)

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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 19d

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com

GPU-accelerated homology search with MMseqs2 - Nature Methods

Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

www.nature.com

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