Lightnews — Scholar-powered news

Ed Huttlin @edhuttlin.bsky.social · 22d

Check out this thread from @haopengxiao.bsky.social on his recent paper! I’m happy I was able to help out on what has turned out to be a really cool story.

Haopeng Xiao @haopengxiao.bsky.social · 22d

We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...

Covariation MS uncovers a protein that controls cysteine catabolism - Nature

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

www.nature.com

1 6

Ed Huttlin @edhuttlin.bsky.social · Sep 1

Hey @haopengxiao.bsky.social - it’s great to see you on BlueSky!

Could your new account be a sign you might have something cool to announce soon???? ;-)

2 3

Reposted by Ed Huttlin

Chris Parker @chrisgparker.bsky.social · Aug 3

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Post-Translational Modifications Remodel Proteome-Wide Ligandability

Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

www.biorxiv.org

24 80

Ed Huttlin @edhuttlin.bsky.social · Jul 29

And although it’s important to acknowledge specific COI, like industry-sponsored research, that isn’t the whole story. In truth, we all share a universal COI, which is that our career advancement - the next degree, job, grant, promotion, etc. - depends on producing “good” results.

1 4

Ed Huttlin @edhuttlin.bsky.social · Jul 29

Yeah - that’s really my point. COI discussions tend to focus on private funding, but I think from the standpoint of undue external pressure to produce results, public funding isn’t all that different.

1 4

Reposted by Ed Huttlin

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jul 29

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

“Revolutionary Science Comes from Unexpected Angles”

magazine.hms.harvard.edu

2 28 41

Ed Huttlin @edhuttlin.bsky.social · Jul 29

than it is already.

1

Ed Huttlin @edhuttlin.bsky.social · Jul 29

It’s also worth noting that public funding can present its own issues. When it’s very competitive to get and keep public funding, that also creates pressure on researchers to produce impressive results. With paylines at the NIH potentially dropping to ~5% in the coming years, this will be even worse

2 3

Ed Huttlin @edhuttlin.bsky.social · Jul 29

If your concern is with private funding of science in general, I suppose there’s room for debate. But as federal funds for science are cut in the US, private funding will be increasingly important. For me, now that Trump has cut all federal funding to Harvard, private funding is keeping us afloat.

1 2

Ed Huttlin @edhuttlin.bsky.social · Jul 29

I’m not sure I understand what you’re seeking here either. If the issue is transparency, each of the PI’s above has been open about their collaborations with industry - enough so that they’re easily recognizable from the logos you display and your joke works.

1 2

Reposted by Ed Huttlin

Chris Hayes @chrislhayes.bsky.social · Jul 18

Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.

1.5K 19K 74K

Ed Huttlin @edhuttlin.bsky.social · Jun 3

If you’re at #ASMS2025, stop by the Protein-protein and Protein-ligand Interactions section this afternoon and hear how we are leveraging our BioPlex network and AlphaFold structural models for drug discovery!

11

Ed Huttlin @edhuttlin.bsky.social · May 30

If you're going to #ASMS2025, don't miss these Gygi lab presentations! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging BioPlex interactions for drug discovery, new instrumentation, and more! @amandalsmythers.bsky.social @asms.org @harvardcellbio.bsky.social

1 24

Ed Huttlin @edhuttlin.bsky.social · May 30

#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how BioPlex is enhancing drug discovery!

1 13

Reposted by Ed Huttlin

NPR @npr.org · May 28

Harvard's president tells NPR he finds Trump's recent measures "perplexing."

"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX

80 210 1.1K

Reposted by Ed Huttlin

Harvard Med Cell Biology @harvardcellbio.bsky.social · May 28

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

www.nature.com

19 44

Reposted by Ed Huttlin

Senator Patty Murray @murray.senate.gov · May 2

NIH's work saves lives—& Trump is gutting it.

Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.

We ALL need to speak up to save it.

29 190 740

Reposted by Ed Huttlin

Waggoner Lab @labwaggoner.bsky.social · Apr 9

Multimodal cell maps as a foundation for structural and functional genomics @nature.com @edhuttlin.bsky.social
www.nature.com/articles/s41...

5 12

Ed Huttlin @edhuttlin.bsky.social · Mar 7

This essay from @erinbakerims.bsky.social does a good job summarizing the challenges facing scientists in the current climate and is well worth reading.

theanalyticalscientist.com/business-edu...

A Bleak Future?

Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science

theanalyticalscientist.com

1 8

Ed Huttlin @edhuttlin.bsky.social · Feb 24

It’s always fun to open up JASMS and see a familiar face. This time it’s my friend and colleague Jose Navarrete-Perea! @asms.org pubs.acs.org/doi/10.1021/...

Faces of Mass Spectrometry/Jose Navarrete-Perea

pubs.acs.org

1

Ed Huttlin @edhuttlin.bsky.social · Jan 1

Happy New Year!

5

Ed Huttlin @edhuttlin.bsky.social · Dec 18

Welcome to Bluesky, @coonlab.bsky.social!

1 4

Ed Huttlin @edhuttlin.bsky.social · Dec 13

Having grown up in Fargo, ND, I can relate! Of course, as cold as it got, we would take some small comfort in knowing Winnipeg was almost always a bit colder than us!

1

Ed Huttlin @edhuttlin.bsky.social · Dec 13

When you’re done with them, those boxes might be popular! When I was back in Wisconsin and we got a new mass spec, someone from the building asked if they could have the box - they were going to turn it into an ice fishing shelter! The box was from a MALDI Tof-Tof, so the head room wasn’t bad….

3 9

Ed Huttlin @edhuttlin.bsky.social · Dec 10

I’m sorry for your loss….

1