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Reposted by Ellie Boardman

Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 2d

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social [email protected] trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 5d

I’m Chloe, I am part of the Connolly lab and I study how the role of two-component systems differs between types of E.coli”

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 5d

Hi, I’m Natalia Łoś from Dr Dave Bolam’s lab. I’m currently going into the third year of my PhD working on dietary fibre degradation by the members of the human gut microbiota 😊

Follow Natalia here : @natalia-los.bsky.social

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 5d

In MHD we are lucky enough to have an amazing group PhD Students and Research Associates. We’ve recently got some new representatives and would like give them the opportunity to introduce themselves here.

First up our two representatives for the PhD student community:

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Reposted by Ellie Boardman

Tracy Palmer @proftracypalmer.bsky.social · 6d

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 6d

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1

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Reposted by Ellie Boardman

John Innes Centre @johninnescentre.bsky.social · 7d

VACANCY - Independent research fellowships leading to tenured positions

We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.

APPLICATION DEADLINE: 10 November 2025

Click here to apply: jic.link/Fellows

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Reposted by Ellie Boardman

Augustinas Silale @augustsilale.bsky.social · 9d

We think this much larger BAM enables biogenesis of outer membrane β-barrel and surface-exposed lipoprotein complexes, which are a hallmark of the Bacteroidota.

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Reposted by Ellie Boardman

Augustinas Silale @augustsilale.bsky.social · 9d

Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.

doi.org/10.1038/s415...

A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature

Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.

doi.org

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Reposted by Ellie Boardman

Augustinas Silale @augustsilale.bsky.social · 9d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

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Ellie Boardman @ellieboardman.bsky.social · 9d

Great opportunity to do a PhD with Giusy and co in Glasgow!

Giusy Mariano @giusym1990.bsky.social · 9d

🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...

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Ellie Boardman @ellieboardman.bsky.social · 15d

@mhd-newcastle.bsky.social

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Ellie Boardman @ellieboardman.bsky.social · 15d

Nice to see our summer student Niamh who did a great job in the lab this year supported by a Vacation Studentship! @proftracypalmer.bsky.social

Microbiology Society @microbiologysociety.org · 25d

Meet the Vacation Studentship 2025 grant awardees 🤩! We loved receiving these photos! When you publish with us, we have the funds to continue supporting Early Career Microbiologists in developing their knowledge and skills.

A graphic with photos of Early Career Microbiologist during their lab-time during the Vacation Studentship, which is a grant provided by the Microbiology Society. In the photos people are smiling.

A lot of photos on the screen of individuals working in the lab.

Another page of photos on the screen of individuals working in the lab.

The last page is text explaining how publishing revenue supports the Society to give grants to Early Career Microbiologists.

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Reposted by Ellie Boardman

Tracy Palmer @proftracypalmer.bsky.social · 17d

Exciting postdoc opportunity with a fab PI in beautiful Basel

Biozentrum, University of Basel @biozentrum.unibas.ch · 19d

Postdoc position (100%, funded) in “bacterial and jumbophage interaction”

@yuping-li.bsky.social

@biozentrum.unibas.ch

@unibas.ch

www.biozentrum.unibas.ch/open-positio...

#phage #jumbophage #barteria #job #research #biology #microbiology #science #basel #recruiting #career

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Reposted by Ellie Boardman

Wilbert Bitter @wilbertbitter.bsky.social · 18d

PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this

PPE51 modulates membrane integrity in Mycobacterium marinum | mBio

The impermeable outer membrane of pathogenic mycobacteria presents a major obstacle to nutrient acquisition and antibiotic penetration. PPE51, a substrate of the ESX-5 secretion system, has previously...

journals.asm.org

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

Last introduction for the today..

Dr Kesha Josts @kjosts.bsky.social

The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.

www.ncl.ac.uk/cbcb/staff/p...

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

Next introducing Dr Alessandra Dantas.

The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.

@alesdantas.bsky.social

www.ncl.ac.uk/dental/about...

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.

www.marles-wright-lab.org

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

Now we are on Bluesky, over the next couple of days we would like to introduce some of the MHD groups on Bluesky who you can follow for more research updates. Or check out our handy MHD starter pack 😀
go.bsky.app/SoVnvW3

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

Next up, @nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.

blogs.ncl.ac.uk/nickjakubovi...

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system.
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...

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Reposted by Ellie Boardman

Microbes in Health and Disease @mhd-newcastle.bsky.social · 19d

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...

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Ellie Boardman @ellieboardman.bsky.social · 24d

Congratulations guys! Really interesting read 🥳

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Reposted by Ellie Boardman

Stephen Garrett @stephenrgarrett.bsky.social · 25d

Really excited to share my first paper from the Whitney lab, alongside an amazing grad student, Polina. Here we identify a chaperone family required for the folding of a central domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. www.pnas.org/doi/10.1073/...

A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system–exported toxins | PNAS

To survive in highly competitive environments, bacteria use specialized secretion systems to deliver antibacterial toxins into neighboring cells, t...

www.pnas.org

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Reposted by Ellie Boardman

James Connolly @ruamicro.bsky.social · Jul 30

Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.

Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications

Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...

www.nature.com

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Reposted by Ellie Boardman

Nature Microbiology @natmicrobiol.nature.com · Jul 1

#NewResearch

🚨Out now

In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social

#MicroSky🦠🧫

www.nature.com/articles/s41...

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque - Nature Microbiology

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

www.nature.com

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