Pilhofer Lab 🦠❄️🔬
LightNews LightNews
banner
pilhoferlab.bsky.social
Pilhofer Lab 🦠❄️🔬
@pilhoferlab.bsky.social
1.7K followers 660 following 46 posts
Microbial cell-cell interactions | contractile injection systems | cytoskeleton | evolution | multiscale imaging | ETH Zürich
- run by lab members -
Posts Replies Media Videos
Pinned
pilhoferlab.bsky.social
Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Mar 21
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
Reposted by Pilhofer Lab 🦠❄️🔬
daumlab.bsky.social
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab
Application deadline: 8th Jan 2026.
Apply here: www.exeter.ac.uk/study/pg-res...
If you are interested, get in touch!
#ArchaeaSky #CryoEM #TeamTomo
November 24, 2025 at 3:09 PM
Reposted by Pilhofer Lab 🦠❄️🔬
fronzeslab.bsky.social
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.

www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Reposted by Pilhofer Lab 🦠❄️🔬
s-lab.bsky.social
Bacteriologists - save the date for the next BacNet meeting in September 2026 #BacNet26 organised by @lalouxlab.bsky.social
evolvedbiofilm.bsky.social Ákos T Kovács @evolvedbiofilm.bsky.social · 5d
Bacterial networks #BacNet26 in September 2026 will be chaired by @lalouxlab.bsky.social and co-chaired by @s-lab.bsky.social with @coralietesseur.bsky.social

Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
November 20, 2025 at 8:58 AM
Reposted by Pilhofer Lab 🦠❄️🔬
mishakudryashev.bsky.social
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.

Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!

jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 7:08 AM
Reposted by Pilhofer Lab 🦠❄️🔬
micromotility.bsky.social
now i've seen everything... 😱
don't care what anybody says but #protists are cognitive
cellraiser.bsky.social Scott Coyle @cellraiser.bsky.social · 7d
Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.
November 19, 2025 at 1:46 PM
Reposted by Pilhofer Lab 🦠❄️🔬
bbammes.bsky.social
Today, at the Rice University Center for Nanoscale Imaging Sciences Conference, Prof. Steve Ludtke (BCM) presented impressive results of continuous-rotation cryo-ET, enabled by the ultra-fast counting of the DE Apollo camera. #teamtomo
November 18, 2025 at 10:38 PM
Reposted by Pilhofer Lab 🦠❄️🔬
dudinlab.bsky.social
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !

Discover HAK-Actin if you haven't already ;)
November 19, 2025 at 12:36 PM
Reposted by Pilhofer Lab 🦠❄️🔬
basler-lab.bsky.social
Update to BacFighT6, with presets for easy exploration of complex behaviors:
sites.google.com/view/bacfight6

Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate!

Took a while to eliminate the reds!
November 17, 2025 at 10:39 PM
Reposted by Pilhofer Lab 🦠❄️🔬
tbharat-lab.bsky.social
Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Reposted by Pilhofer Lab 🦠❄️🔬
weiss-lab.bsky.social
The Center for Microscopy and Image Analysis at the University of Zurich is seeking a new Head:

jobs.uzh.ch/job-vacancie...

It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬
Application deadline: December 15, 2025.
UZH: Head of the Center for Microscopy and Image Analysis (Core Facility)
The Center for Microscopy and Image Analysis (ZMB) is a nationally and internationally recognized Core Facility at the University of Zurich (UZH), providing access to state-of-the-art light and electr...
jobs.uzh.ch
November 12, 2025 at 6:42 PM
Reposted by Pilhofer Lab 🦠❄️🔬
atp-alker.bsky.social
Apply and come be my colleague!
jonpuritz.marineevoeco.com Jon Puritz @jonpuritz.marineevoeco.com · 15d
Job Opening **ASSISTANT PROFESSOR MARINE ECOLOGY**, Department of Biological Sciences, University of Rhode Island.

jobs.uri.edu/postings/15960
Job Opening **ASSISTANT PROFESSOR MARINE ECOLOGY**, Department of Biological Sciences, University of Rhode Island. The Department of Biological Sciences in the College of the Environment and Life Sciences (CELS) at the University of Rhode Island (URI) invites applications for an academic year (9 month), tenure-track Assistant Professor position specializing in Marine Ecology. URI, the top public university in New England, is a land and sea grant research university located in Kingston, Rhode Island, a beautiful seaside community that is well connected by car, bus, and rail about 40 min from Providence, an hour from Boston and 3 hours from New York City.
November 12, 2025 at 1:39 AM
Reposted by Pilhofer Lab 🦠❄️🔬
environmicrobio.bsky.social
Good luck to my grad students Sylvia Nupp and Stavros Trimmer, who will sail on the Falkor(too) in search of Asgard archaea off the coast of Uruguay and Brazil the next month. Smooth sailing! Thanks to Brett and Alyson for organizing the cruise.
November 11, 2025 at 8:55 PM
Reposted by Pilhofer Lab 🦠❄️🔬
danielabarilla.bsky.social
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social

www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects. High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.
November 9, 2025 at 5:20 PM
Reposted by Pilhofer Lab 🦠❄️🔬
buzzbaum.bsky.social
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
Reposted by Pilhofer Lab 🦠❄️🔬
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Pilhofer Lab 🦠❄️🔬
guo-lab.bsky.social
Great collaboration with @brunlabcaulo.bsky.social for resolving the Tad pilus machine structure by cryo-ET. Beautiful work by graduate students James Iarocci and Ryu Williston in our lab.

Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
November 6, 2025 at 3:58 PM
Reposted by Pilhofer Lab 🦠❄️🔬
brunlabcaulo.bsky.social
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Reposted by Pilhofer Lab 🦠❄️🔬
mrclmb.bsky.social
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Reposted by Pilhofer Lab 🦠❄️🔬
fridof.bsky.social
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Reposted by Pilhofer Lab 🦠❄️🔬
cryosagar.openemage.org
Some great years ahead for #teamtomo in the Netherlands🥳🥳
Congrats @fridof.bsky.social and the team!
November 4, 2025 at 12:33 PM
Reposted by Pilhofer Lab 🦠❄️🔬
thanbichlerlab.bsky.social
📢 Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025

Please repost. #Postdoc
November 2, 2025 at 7:13 PM
pilhoferlab.bsky.social
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!

With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
November 1, 2025 at 12:41 PM
Reposted by Pilhofer Lab 🦠❄️🔬
floravincent.bsky.social
Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7
October 31, 2025 at 3:27 PM
Reposted by Pilhofer Lab 🦠❄️🔬
dudinlab.bsky.social
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
Reposted by Pilhofer Lab 🦠❄️🔬
maxperutzlabs.ac.at
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM