How do you scale super-resolution microscopy to dozens of proteins without linearly scaling imaging time?
We introduce Combi-PAINT: a combinatorial DNA-PAINT strategy that breaks the 1-target-per-round bottleneck of Exchange-PAINT: www.biorxiv.org/content/10.6...
1/5

Ralf Jungmann, of the @mpibiochem.bsky.social, is the first speaker to step to the BiOS Hot Topics stage at #PhotonicsWest!💡

He is delivering his presentation titled: “From DNA nanotechnology to biomedical insight: towards single-molecule spatial omics”

@jungmannlab.bsky.social

Now online: October 2025 Issue.

- Focus Issue on #biosensing,
- DNA moiré superlattices,
- Sugars at Ångström-resolution,
- Solid-state #nanopores,
- Non-aqueous Li #batteries, -
- Neuromorphic vision,
- Peptide #hydrogels,
- Deep learning for #LNPs and more...

www.nature.com/nnano/volume...

Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest paper in @natcomms.nature.com, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀https://www.nature.com/articles/s41467-025-64228-x

Next on stage is Eduard Unterauer @eduardunterauer.bsky.social from @jungmannlab.bsky.social reporting spatial proteomics with DNA PAINT #SMLMS2025

We're excited that the study is now out in Nature Nanotechnology @natnano.nature.com www.nature.com/articles/s41...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

Congratulations to Ralf on your election as a new EMBO member:

❕Original press release from @embo.org : www.embo.org/press-releas...

Great science, great company and stunning views at our Lab retreat on Schloss Ringberg 🏰🧬🔬. Big thanks to our guests Sabrina Simoncelli, Sebastian Kobold, Thomas Schlichthärle, @massivephotonics.bsky.social & students from the @lfmilles.bsky.social and @mlsb-borgwardt.bsky.social Labs for joining!

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

We are excited to present our latest work published in @natcomms.nature.com

www.nature.com/articles/s41...

Big shoutout to co-first authors, Isabelle Pachmayr and Larissa Heinze, for their incredible work and dedication. This work would not have been possible without Levent Bas, @lumasullo.bsky.social, Jisoo Kwon, Ana Perovic, Brenda Schulman, and Ralf Jungmann, as well as the
@jungmannlab.bsky.social!

One month ago today, I published my first paper with the @jungmannlab.bsky.social 🥳
What better way to celebrate #MicroscopyMonday than with this STAR Protocol on SUM-PAINT spatial proteomic imaging: a guide for highly multiplexed DNA-PAINT imaging in neurons. star-protocols.cell.com/protocols/4066

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!

Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩

www.sciencedirect.com/science/arti...