Heilemann Lab
@heilemannlab.bsky.social
Single-molecule biophysics group at Goethe University Frankfurt/Germany. Super-resolution microscopy. Optical structural cell biology. Computational microscopy. Posts by MH.
http://www.smb.uni-frankfurt.de
#superresolution, #livecellimaging, #imageanalysis
http://www.smb.uni-frankfurt.de
#superresolution, #livecellimaging, #imageanalysis
Pinned
Heilemann Lab
@heilemannlab.bsky.social
· Dec 13
#FluorescenceFriday (we are watching vimentin (HaloTag7) in U2OS cells co-stained with Nile Red) #livecell #longterm
Reposted by Heilemann Lab
Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...
Directors
www.evolbio.mpg.de
January 21, 2026 at 11:15 AM
Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...
Reposted by Heilemann Lab
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Heilemann Lab
Interested in cell-cell communication and microscopy? We are searching for a motivated postdoctoral researcher to join Münster! Please Apply! @uni-muenster.de
January 19, 2026 at 4:54 PM
Interested in cell-cell communication and microscopy? We are searching for a motivated postdoctoral researcher to join Münster! Please Apply! @uni-muenster.de
Reposted by Heilemann Lab
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
www.embl.org
January 16, 2026 at 6:33 PM
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
Reposted by Heilemann Lab
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 2:57 PM
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
Reposted by Heilemann Lab
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
abo.rekrytointi.com
January 15, 2026 at 2:04 PM
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
On my way to #PhotonicsWest #SPIE #BIOS & exicted for the "Single Molecule Spectroscopy and Super-Resolution Microscopy" conf spie.org/PW26B/confer... @spie.org @picoquant.bsky.social
We present our work on smart STED microscopy for optical structural cell biology 👉🏻 www.nature.com/articles/s41...
We present our work on smart STED microscopy for optical structural cell biology 👉🏻 www.nature.com/articles/s41...
Single Molecule Spectroscopy and Superresolution Imaging XIX, Conference Details
View program details for BiOS conference on Single Molecule Spectroscopy and Superresolution Imaging XIX
spie.org
January 15, 2026 at 2:11 PM
On my way to #PhotonicsWest #SPIE #BIOS & exicted for the "Single Molecule Spectroscopy and Super-Resolution Microscopy" conf spie.org/PW26B/confer... @spie.org @picoquant.bsky.social
We present our work on smart STED microscopy for optical structural cell biology 👉🏻 www.nature.com/articles/s41...
We present our work on smart STED microscopy for optical structural cell biology 👉🏻 www.nature.com/articles/s41...
Reposted by Heilemann Lab
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
January 13, 2026 at 2:39 PM
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
Reposted by Heilemann Lab
Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.
January 10, 2026 at 5:39 PM
Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.
Reposted by Heilemann Lab
Much enjoyed this nice cryoEM study of NONO:SFPQ heterocomplex this morning, while it was snowing outside. So happy to read a paper in full again (only a handful of papers read in full in last weeks or even months ☹, and some were to review).
The gene-regulating proteins NONO and SFPQ assemble into ordered filaments - Communications Biology
Filament formation of full-length NONO/SFPQ heterodimers was observed and structurally characterized in vitro which may provide a scaffold for gene regulation, paraspeckle formation and DNA double-str...
www.nature.com
January 7, 2026 at 11:49 AM
Much enjoyed this nice cryoEM study of NONO:SFPQ heterocomplex this morning, while it was snowing outside. So happy to read a paper in full again (only a handful of papers read in full in last weeks or even months ☹, and some were to review).
Reposted by Heilemann Lab
Short fatty acids, custom synthesized by engineered yeast 🧫
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
January 8, 2026 at 8:49 PM
Short fatty acids, custom synthesized by engineered yeast 🧫
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Here it is: doi.org/10.1038/s415...
🤝✨ Fantastic team effort — thanks to Yongjin Zhou!
Science made possible at @goetheuni.bsky.social 🏛️🔬
Receptor tyrosine kinases bind ligands and (often) dimerize. Yet how long, and how does that change their mobility? Using single-molecule FRET in living cells, we found that MET dimers 'socialize' for ~1 second while lowering lateral diffusion and confinement 👉🏻 doi.org/10.1002/smll...
December 20, 2025 at 11:01 AM
Receptor tyrosine kinases bind ligands and (often) dimerize. Yet how long, and how does that change their mobility? Using single-molecule FRET in living cells, we found that MET dimers 'socialize' for ~1 second while lowering lateral diffusion and confinement 👉🏻 doi.org/10.1002/smll...
Reposted by Heilemann Lab
⏰Call for Applications - Join Our Team and Help Shape Our Cluster
@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!
@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!
December 19, 2025 at 10:09 PM
⏰Call for Applications - Join Our Team and Help Shape Our Cluster
@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!
@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!
Reposted by Heilemann Lab
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Targeted RNA-binding protein degradation to improve mRNA live imaging in animal cells - Nature Methods
The gold standard system for mRNA imaging in live cells just got upgraded by being degraded. This development improves signal-to-noise ratios and may lead to a better understanding of mRNA transport a...
www.nature.com
December 17, 2025 at 11:13 AM
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Reposted by Heilemann Lab
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
December 16, 2025 at 10:12 AM
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
Reposted by Heilemann Lab
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
December 16, 2025 at 12:11 PM
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Reposted by Heilemann Lab
6SiR-C3-NextA is bright far-red, cell-permeable probe for live-cell selective HDAC6 imaging. Congratulations to Van-Thang Nguyen et al. @vanthang.bsky.social from @imprsgs.bsky.social ! Developed at @mpi-nat.bsky.social nat.bsky.social and published on BioRxiv www.biorxiv.org/content/10.6... .
December 15, 2025 at 6:50 AM
6SiR-C3-NextA is bright far-red, cell-permeable probe for live-cell selective HDAC6 imaging. Congratulations to Van-Thang Nguyen et al. @vanthang.bsky.social from @imprsgs.bsky.social ! Developed at @mpi-nat.bsky.social nat.bsky.social and published on BioRxiv www.biorxiv.org/content/10.6... .
Reposted by Heilemann Lab
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
December 10, 2025 at 8:43 PM
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
Reposted by Heilemann Lab
Excited to share our latest work! We introduce FRET-SOFI, a new method for super-resolved imaging of molecular interactions. By combining SOFI with FRET, we achieve subdiffraction resolution in live cells using standard wide-field microscopy.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Super-resolved Imaging of Molecular Interactions Using FRET-SOFI
Super-resolution fluorescence microscopy is a powerful method to image molecular processes that occur beyond the diffraction limit of light. Förster resonance energy transfer (FRET) is widely used to ...
pubs.acs.org
December 10, 2025 at 9:00 AM
Excited to share our latest work! We introduce FRET-SOFI, a new method for super-resolved imaging of molecular interactions. By combining SOFI with FRET, we achieve subdiffraction resolution in live cells using standard wide-field microscopy.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Heilemann Lab
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 9, 2025 at 6:11 PM
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Reposted by Heilemann Lab
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
www.janelia.org/content/lead...
Lead a lab at Janelia
www.janelia.org
December 8, 2025 at 8:41 PM
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
www.janelia.org/content/lead...
Reposted by Heilemann Lab
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
December 5, 2025 at 9:47 AM
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Reposted by Heilemann Lab
The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science.
fias.institute/de/das-fias/...
fias.institute/de/das-fias/...
Independent Research Group Leaders (f/m/d) SCALE / FIAS
fias.institute
December 5, 2025 at 5:30 PM
The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science.
fias.institute/de/das-fias/...
fias.institute/de/das-fias/...
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
November 28, 2025 at 3:12 PM
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social
👇🏻
👇🏻
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
Please share!
November 20, 2025 at 4:33 PM
🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social
👇🏻
👇🏻