Marcin J. Suskiewicz
@msuskiewicz.bsky.social
Structural biologist and biochemist. CNRS researcher at CBM Orléans @cbm-upr4301.bsky.social. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧. Personal website: msuskiewicz.github.io
Pinned
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Reposted by Marcin J. Suskiewicz
A great read! Fleming's discovery of the antibacterial properties of Penicillium mould cannot have happened as he described.
@kevinsblake.bsky.social rounds up the evidence.
Spoiler: no sign of foul play, but certainly the canonical story is almost certainly distorted.
@kevinsblake.bsky.social rounds up the evidence.
Spoiler: no sign of foul play, but certainly the canonical story is almost certainly distorted.
Every biologist knows the story of Fleming's chance discovery of penicillin. But is it true?
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
The Penicillin Myth
Competing theories seek to explain inconsistencies surrounding Alexander Fleming’s famed discovery.
press.asimov.com
November 26, 2025 at 3:23 PM
A great read! Fleming's discovery of the antibacterial properties of Penicillium mould cannot have happened as he described.
@kevinsblake.bsky.social rounds up the evidence.
Spoiler: no sign of foul play, but certainly the canonical story is almost certainly distorted.
@kevinsblake.bsky.social rounds up the evidence.
Spoiler: no sign of foul play, but certainly the canonical story is almost certainly distorted.
I wrote recently two blogs on 'AI', provoked by too frequent incentives to believe it's a great thing and use it - linking my blog in case it interests anybody, though the topic is perhaps all too present already.
Blog
msuskiewicz.github.io
November 26, 2025 at 9:01 AM
I wrote recently two blogs on 'AI', provoked by too frequent incentives to believe it's a great thing and use it - linking my blog in case it interests anybody, though the topic is perhaps all too present already.
Reposted by Marcin J. Suskiewicz
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
scim.ag
November 25, 2025 at 8:24 PM
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
Reposted by Marcin J. Suskiewicz
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
www.biorxiv.org
November 18, 2025 at 3:57 PM
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
Reposted by Marcin J. Suskiewicz
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Marcin J. Suskiewicz
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Marcin J. Suskiewicz
Frontier structural biology chases low occupancies: weak binders in drug discovery & fleeting intermediates in time-resolved studies. When squeezing SNR, confirmation bias looms – you can see what you hope to see in the noise! Enter METEOR ☄️, our denoising+phasing framework! 1/8
November 24, 2025 at 10:22 PM
Frontier structural biology chases low occupancies: weak binders in drug discovery & fleeting intermediates in time-resolved studies. When squeezing SNR, confirmation bias looms – you can see what you hope to see in the noise! Enter METEOR ☄️, our denoising+phasing framework! 1/8
Reposted by Marcin J. Suskiewicz
Reposted by Marcin J. Suskiewicz
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by Marcin J. Suskiewicz
Monitoring the complexity and dynamics of mitochondrial translation
Monitoring the complexity and dynamics of mitochondrial translation
Wakigawa et al. present advanced derivatives of mitochondrial ribosome profiling. By quantifying initiation, elongation, and ribosome collisions and by dissecting the impacts of tRNA anticodon-loop modifications and the initiation mechanism of internal translons, they uncover dynamic regulation of mammalian mitochondrial translation that ensures cellular energy production.
dlvr.it
November 24, 2025 at 8:14 PM
Monitoring the complexity and dynamics of mitochondrial translation
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
Non-covalent SUMO interactions with ligases and effectors: SUMO-interacting motifs and beyond
SUMOylation, a protein post-translational modification (PTM) involving the covalent attachment of small ubiquitin-like modifier (SUMO), regulates a wide range of cellular processes. The key hallmark o...
portlandpress.com
November 24, 2025 at 9:06 PM
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
Reposted by Marcin J. Suskiewicz
⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
November 24, 2025 at 6:16 PM
⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
Enjoyed reading this discussion of how extrachromosomal DNA found in cancer might be inherited during cell division. It was known it needs to physically attach to chromosomes. It seems it does so by capturing enhancer or promoter sequences and mimicking enhancer:promoter contacts.
How circular extrachromosomal DNA is inherited during cell division has been a puzzle
go.nature.com/441YKU7
go.nature.com/441YKU7
Circular DNA has a ticket to ride chromosomes
Nature - How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified.
go.nature.com
November 24, 2025 at 10:31 AM
Enjoyed reading this discussion of how extrachromosomal DNA found in cancer might be inherited during cell division. It was known it needs to physically attach to chromosomes. It seems it does so by capturing enhancer or promoter sequences and mimicking enhancer:promoter contacts.
Reposted by Marcin J. Suskiewicz
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
November 20, 2025 at 6:52 PM
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
Reposted by Marcin J. Suskiewicz
This is excellent.
To “my students and to anyone who might listen, I say: Don’t surrender to AI your ability to read, write and think when others once risked their lives and died for the freedom to do so.”
www.huffpost.com/entry/histor...
www.huffpost.com/entry/histor...
I Set A Trap To Catch My Students Cheating With AI. The Results Were Shocking.
"Students are not just undermining their ability to learn, but to someday lead."
www.huffpost.com
November 21, 2025 at 9:42 AM
This is excellent.
Reposted by Marcin J. Suskiewicz
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by Marcin J. Suskiewicz
New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome
Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and stat...
doi.org
November 20, 2025 at 11:59 AM
New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.
Reposted by Marcin J. Suskiewicz
We just took a deep dive into this tour-de-force chemoproteomics paper from @stephanhacker2.bsky.social and colleagues in our journal club today — really interesting findings about selectivity and coverage of 56 different electrophilic warheads, and great experimental and analysis workflows. Bravo!
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
November 20, 2025 at 1:24 AM
We just took a deep dive into this tour-de-force chemoproteomics paper from @stephanhacker2.bsky.social and colleagues in our journal club today — really interesting findings about selectivity and coverage of 56 different electrophilic warheads, and great experimental and analysis workflows. Bravo!
Reposted by Marcin J. Suskiewicz
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation - Nature Communications
p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs doub...
www.nature.com
November 19, 2025 at 3:01 PM
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marcin J. Suskiewicz
An open-source computational pipeline to visualize the binding interfaces of protein domains is described
www.science.org/doi/10.1126/...
@uvapress.bsky.social @knaegle.bsky.social
www.science.org/doi/10.1126/...
@uvapress.bsky.social @knaegle.bsky.social
November 19, 2025 at 4:05 PM
An open-source computational pipeline to visualize the binding interfaces of protein domains is described
www.science.org/doi/10.1126/...
@uvapress.bsky.social @knaegle.bsky.social
www.science.org/doi/10.1126/...
@uvapress.bsky.social @knaegle.bsky.social
Reposted by Marcin J. Suskiewicz
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Reposted by Marcin J. Suskiewicz
Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Filament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular Biology
Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...
www.nature.com
November 17, 2025 at 6:17 PM
Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marcin J. Suskiewicz
Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
November 10, 2025 at 5:54 PM
Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
Reposted by Marcin J. Suskiewicz
Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 4:52 PM
Akin to bacterial SIR2 antiphage proteins, human SIRal, also known as FAM118b, forms filaments that are essential for its NAD processing activity.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Awesome to see structures of these filaments that differ from bacterial ones.
Congrats to the authors on this beautiful study.
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.