Jeremy Baskin
@jeremybaskin.bsky.social
Associate Professor at Cornell University: chemical biology, cell biology, #lipidtime and membrane biology
Pinned
Dylan's study is now out in @jacs.acspublications.org! Key new experiments by Yuan-Ting Cho support a model for why a rare three-tailed lipid, NAPE, might accumulate during stroke & heart attack: as a protective response to promote lactate export as cells shift to glycolysis doi.org/10.1021/jacs...
Reposted by Jeremy Baskin
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
November 25, 2025 at 1:36 AM
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
Reposted by Jeremy Baskin
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important.
A new webpage on the NIH site called “Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions” is causing a small kerfuffle on the socials. As per us…
drugmonkey.wordpress.com
November 22, 2025 at 12:26 AM
In which I fruitlessly beg NIH grant-seeking folks to focus on what is actually important. drugmonkey.wordpress.com/2025/11/21/i...
Congratulations to Dr. Lin Luan, the lab’s 10th PhD graduate, on passing her B exam today!
November 22, 2025 at 2:30 AM
Congratulations to Dr. Lin Luan, the lab’s 10th PhD graduate, on passing her B exam today!
Revealing post getting into the weeds of how %iles are calculated for grants with tied impact scores from study section. Tl;dr: ties can worsen %iles, rounding up occurs for non-integer %iles, and that increasingly matters in a single-digit payline environment. Advice: try to avoid 2-2-2 consensus.
"Nice" NIH study sections screw their applicants because of the way NIH calculates percentile. drugmonkey.wordpress.com/2025/11/20/n...
“Nice” NIH study sections screw their applicants because of the way NIH calculates percentile.
I often write blog comments about NIH grant review matters that exist in an uncomfortable tension between what NIH wants us to do on study section and what I see as our professional obligation to t…
drugmonkey.wordpress.com
November 21, 2025 at 3:37 PM
Revealing post getting into the weeds of how %iles are calculated for grants with tied impact scores from study section. Tl;dr: ties can worsen %iles, rounding up occurs for non-integer %iles, and that increasingly matters in a single-digit payline environment. Advice: try to avoid 2-2-2 consensus.
Reposted by Jeremy Baskin
Ever wanted to do a genome-scale CRISPR screen for a microscopy phenotype? Pooled CRISPR screens are amazing, but hard to combine with imaging... Excited to share our latest work in Dev Cell on a technology platform for imaging screens and applications to primary cilia: www.cell.com/developmenta...
A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology
Sun et al. develop a microscopy-based CRISPR screening platform that combines ease
of implementation with flexible analysis of live-cell or antibody-based markers. Screens
in human cells using a serie...
www.cell.com
November 20, 2025 at 5:06 PM
Ever wanted to do a genome-scale CRISPR screen for a microscopy phenotype? Pooled CRISPR screens are amazing, but hard to combine with imaging... Excited to share our latest work in Dev Cell on a technology platform for imaging screens and applications to primary cilia: www.cell.com/developmenta...
Reposted by Jeremy Baskin
People often underestimate how much theatre skills can benefit scientists, says born performer Nitheeshan Gunanantham. They provide communication skills, emotional intelligence – and make revision fun.
What can biochemists learn from drama?
How my acting background helps me build my scientific skills
www.chemistryworld.com
November 21, 2025 at 11:39 AM
People often underestimate how much theatre skills can benefit scientists, says born performer Nitheeshan Gunanantham. They provide communication skills, emotional intelligence – and make revision fun.
Congratulations to @adi-bhatta.bsky.social for passing his A exam today and advancing to PhD candidacy! #proudmentor
November 20, 2025 at 2:29 AM
Congratulations to @adi-bhatta.bsky.social for passing his A exam today and advancing to PhD candidacy! #proudmentor
We just took a deep dive into this tour-de-force chemoproteomics paper from @stephanhacker2.bsky.social and colleagues in our journal club today — really interesting findings about selectivity and coverage of 56 different electrophilic warheads, and great experimental and analysis workflows. Bravo!
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
November 20, 2025 at 1:24 AM
We just took a deep dive into this tour-de-force chemoproteomics paper from @stephanhacker2.bsky.social and colleagues in our journal club today — really interesting findings about selectivity and coverage of 56 different electrophilic warheads, and great experimental and analysis workflows. Bravo!
Reposted by Jeremy Baskin
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 18, 2025 at 6:20 AM
Biology of bridge-like lipid transfer proteins continues to be uncovered at a rather brisk pace. These things are important... Cool paper, congratulations!
Reposted by Jeremy Baskin
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeremy Baskin
This bring me back to one of my favorite anecdotes.
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
November 14, 2025 at 3:31 PM
This bring me back to one of my favorite anecdotes.
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
Reposted by Jeremy Baskin
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
What a joy to host the one and only Jenn Prescher for a memorable seminar visit at Cornell Chemistry!!
November 12, 2025 at 12:46 AM
What a joy to host the one and only Jenn Prescher for a memorable seminar visit at Cornell Chemistry!!
Reposted by Jeremy Baskin
Ithaca is gorge-ous! Thank you @fromme-lab.bsky.social, @jeremybaskin.bsky.social and colleagues for a very fun and stimulating visit to the Weill Institute for Cell and Molecular Biology at Cornell!
November 10, 2025 at 2:39 PM
Ithaca is gorge-ous! Thank you @fromme-lab.bsky.social, @jeremybaskin.bsky.social and colleagues for a very fun and stimulating visit to the Weill Institute for Cell and Molecular Biology at Cornell!
Reposted by Jeremy Baskin
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
November 8, 2025 at 1:58 PM
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
Congrats to our latest PhD candidate @richardyheudean.bsky.social on passing his A exam!
November 1, 2025 at 2:13 AM
Congrats to our latest PhD candidate @richardyheudean.bsky.social on passing his A exam!
Check out this chemoproteomics tour de force from @stephanhacker2.bsky.social and colleagues — want to know which electrophiles label which amino acid residues proteome-wide? Finally, a comprehensive comparative study with a ton of insights on old and new warheads and optimized workflows. Bravo!
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 2:42 PM
Check out this chemoproteomics tour de force from @stephanhacker2.bsky.social and colleagues — want to know which electrophiles label which amino acid residues proteome-wide? Finally, a comprehensive comparative study with a ton of insights on old and new warheads and optimized workflows. Bravo!
Reposted by Jeremy Baskin
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeremy Baskin
Do you study lipids or lipidation, but don't know where to send your newest work?
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 4:12 PM
Do you study lipids or lipidation, but don't know where to send your newest work?
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
Send us your fat papers, phat papers, and even phatty acid papers. While the special issue is not saturated, it's filling up fast, and won't be unsaturated forever!
Phase separate with us and build community!
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Call for Papers: Lipids and Lipidation | ACS Publications Chemistry Blog
This Special Issue in _ACS Chemical Biology_ will highlight the latest advancements and perspectives in the chemical biology of lipids and lipidation. Submit your manuscript by May 31, 2026.
axial.acs.org
October 28, 2025 at 3:48 PM
#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembiobryan.bsky.social and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. axial.acs.org/chemical-bio... #lipidtime
Reposted by Jeremy Baskin
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 27, 2025 at 9:43 PM
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
Move over, mole day: happy #bioorthogonal copper-free click chemistry day to all who celebrate! 🎉 www.livescience.com/chemistry/sc... @carolynbertozzi.bskyverified.social
Science history: Scientists use 'click chemistry' to watch molecules in living organisms — Oct. 23, 2007
Carolyn Bertozzi and colleagues laid out a way to make paradigm-shifting "click-chemistry" compatible with living cells, opening up a window into living organisms.
www.livescience.com
October 23, 2025 at 6:34 PM
Move over, mole day: happy #bioorthogonal copper-free click chemistry day to all who celebrate! 🎉 www.livescience.com/chemistry/sc... @carolynbertozzi.bskyverified.social
Reposted by Jeremy Baskin
Members of @jeremybaskin.bsky.social lab at @weillinstitute.bsky.social learn to defeat cancer cells by blocking how they read lipid signals, using a compound called NF14 that targets the PLEKHA4 protein, offering a new alternative to current lipid-pathway drugs. news.cornell.edu/stories/2025...
Cornell team finds new way to cut cancer’s lipid lifeline | Cornell Chronicle
Researchers at Cornell have uncovered molecules that can preserve crucial cellular processes while blocking malignant proteins, indicating a new approach to fighting cancer
news.cornell.edu
October 20, 2025 at 3:16 PM
Members of @jeremybaskin.bsky.social lab at @weillinstitute.bsky.social learn to defeat cancer cells by blocking how they read lipid signals, using a compound called NF14 that targets the PLEKHA4 protein, offering a new alternative to current lipid-pathway drugs. news.cornell.edu/stories/2025...
Thanks to the Cornell Chronicle and @research-and-innovation.cornell.edu for highlighting our new small molecules targeting lipid-binding proteins in cancer! news.cornell.edu/stories/2025...
October 17, 2025 at 7:32 PM
Thanks to the Cornell Chronicle and @research-and-innovation.cornell.edu for highlighting our new small molecules targeting lipid-binding proteins in cancer! news.cornell.edu/stories/2025...