Sarah Cohen
@cohenlaboratory.bsky.social
Cell biologist at UNC interested in organelles, lipids, neurodegenerative disease, and light microscopy. https://cohenlaboratory.web.unc.edu
Pinned
Sarah Cohen
@cohenlaboratory.bsky.social
· Aug 31
Hello Bluesky! I lead a lab at UNC that uses microscopy approaches to study organelle dynamics, lipid trafficking, and neurodegenerative disease.
Reposted by Sarah Cohen
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Ithaca is gorge-ous! Thank you @fromme-lab.bsky.social, @jeremybaskin.bsky.social and colleagues for a very fun and stimulating visit to the Weill Institute for Cell and Molecular Biology at Cornell!
November 10, 2025 at 2:39 PM
Ithaca is gorge-ous! Thank you @fromme-lab.bsky.social, @jeremybaskin.bsky.social and colleagues for a very fun and stimulating visit to the Weill Institute for Cell and Molecular Biology at Cornell!
Reposted by Sarah Cohen
Happy Halloween from the creative minds of CBP grad students and scientists!!
October 31, 2025 at 5:34 PM
Happy Halloween from the creative minds of CBP grad students and scientists!!
It was great to finish off #UNCResearchWeek by seeing Sherry Hsu’s beautiful image on display in Bondurant Hall! 🔬🔬🔬
October 27, 2025 at 2:23 PM
It was great to finish off #UNCResearchWeek by seeing Sherry Hsu’s beautiful image on display in Bondurant Hall! 🔬🔬🔬
Reposted by Sarah Cohen
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Sarah Cohen
It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers.
October 15, 2025 at 12:22 PM
It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers.
Looking forward to #UNCResearchWeek! I'll be presenting my lab's work on #organelles in physiology and neurodegenerative disease on Monday, October 20
October 15, 2025 at 1:57 PM
Looking forward to #UNCResearchWeek! I'll be presenting my lab's work on #organelles in physiology and neurodegenerative disease on Monday, October 20
Reposted by Sarah Cohen
Genuinely thrilled to share our new story with the world - an amazing collaboration with @profsharona.bsky.social and Bill Zagotta using their innovative FRET technique to study mitofusin conformational changes. Huge credit to Sophie Hurwitz for tackling this project. urldefense.com/v3/__https:/...
Structural insights into GTP-coupled conformational changes in Mfn1 revealed by time-resolved transition metal ion FRET.
Outer mitochondrial membrane fusion is mediated by the mitofusin paralogs Mfn1 and Mfn2. Nucleotide-driven self-assembly and conformational changes are required for regulated membrane fusion activity,...
urldefense.com
October 10, 2025 at 6:31 PM
Genuinely thrilled to share our new story with the world - an amazing collaboration with @profsharona.bsky.social and Bill Zagotta using their innovative FRET technique to study mitofusin conformational changes. Huge credit to Sophie Hurwitz for tackling this project. urldefense.com/v3/__https:/...
Reposted by Sarah Cohen
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
September 25, 2025 at 6:00 PM
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
Reposted by Sarah Cohen
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by Sarah Cohen
This is another must read - great week for organelle bio tools this week!
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 6:26 PM
This is another must read - great week for organelle bio tools this week!
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
This is going to be a very exciting meeting!! 🔬🧫🌈
Registration is open for our Imaging Cell Dynamics meeting.
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
September 15, 2025 at 6:49 PM
This is going to be a very exciting meeting!! 🔬🧫🌈
Reposted by Sarah Cohen
Registration is open for our Imaging Cell Dynamics meeting.
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
September 15, 2025 at 1:21 PM
Registration is open for our Imaging Cell Dynamics meeting.
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti, the meeting will focus on the interface between cell biology and imaging.
For more info: www.biologists.com/meetings/jcs...
Reposted by Sarah Cohen
A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
Lipid droplets: Open questions and conceptual advances around a unique organelle | Journal of Cell Biology | Rockefeller University Press
Henne and Prinz discuss the lipid droplet field and pervasive questions surrounding droplets and their roles in physiology and disease.
doi.org
September 11, 2025 at 2:04 PM
A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
Reposted by Sarah Cohen
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1
September 7, 2025 at 12:40 PM
new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface
Reposted by Sarah Cohen
Tour de force from @nadlerlab.bsky.social . The value of solving a hard problem with beautiful chemistry: insights that upend conventional thinking re: lipid transport. You’ve got to read the thread, I’m not giving away the juice! It’s fantastic! Congrats 🎈🎊🍾🎉
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 31, 2025 at 2:11 PM
Tour de force from @nadlerlab.bsky.social . The value of solving a hard problem with beautiful chemistry: insights that upend conventional thinking re: lipid transport. You’ve got to read the thread, I’m not giving away the juice! It’s fantastic! Congrats 🎈🎊🍾🎉
Reposted by Sarah Cohen
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
August 15, 2025 at 1:19 PM
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Reposted by Sarah Cohen
I am honored to be named a 2025 ASCB Fellow! It is a privilege to be part of the ASCB community. ASCB was the first conference I attended as a grad student, and it has always been a welcoming, supportive home. Thank you for this kind recognition! ☺️
www.ascb.org/society-news...
www.ascb.org/society-news...
Fourteen Visionary Scientists Named 2025 ASCB Fellows - ASCB
The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...
www.ascb.org
August 7, 2025 at 4:22 PM
I am honored to be named a 2025 ASCB Fellow! It is a privilege to be part of the ASCB community. ASCB was the first conference I attended as a grad student, and it has always been a welcoming, supportive home. Thank you for this kind recognition! ☺️
www.ascb.org/society-news...
www.ascb.org/society-news...
Reposted by Sarah Cohen
Meet the 14 scientists named 2025 ASCB Fellows! Honored for excellence in research, mentorship, and service, they’ll be recognized at Cell Bio 2025 this December in Philadelphia.
Read more: www.ascb.org/society-news...
Read more: www.ascb.org/society-news...
Fourteen Visionary Scientists Named 2025 ASCB Fellows - ASCB
The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...
www.ascb.org
August 7, 2025 at 12:02 PM
Meet the 14 scientists named 2025 ASCB Fellows! Honored for excellence in research, mentorship, and service, they’ll be recognized at Cell Bio 2025 this December in Philadelphia.
Read more: www.ascb.org/society-news...
Read more: www.ascb.org/society-news...
I’m extremely honored to be recognized with the WICB Junior Research Award. ASCB and WICB have been key to my career development since I attended my first annual meeting in 2005. Congrats to the other awardees!
Meet the 2025 ASCB Award Winners—trailblazing scientists honored for research, mentoring, education, and innovation. Celebrate excellence across all career stages in cell biology. Read more: www.ascb.org/society-news...
August 4, 2025 at 10:31 PM
I’m extremely honored to be recognized with the WICB Junior Research Award. ASCB and WICB have been key to my career development since I attended my first annual meeting in 2005. Congrats to the other awardees!
It has been a dream come true to lead a rotation in the @mblscience.bsky.social Physiology course - thanks to the amazing Directors @gladfelterlab.bsky.social and @brangwynnelab.bsky.social, course staff, TAs, and students!
July 12, 2025 at 11:43 PM
It has been a dream come true to lead a rotation in the @mblscience.bsky.social Physiology course - thanks to the amazing Directors @gladfelterlab.bsky.social and @brangwynnelab.bsky.social, course staff, TAs, and students!
Reposted by Sarah Cohen
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 3:01 PM
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Sarah Cohen
What does the APOE 'lipid droplet-ome' look like???
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…
www.sciencedirect.com
June 3, 2025 at 1:09 AM
What does the APOE 'lipid droplet-ome' look like???
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
Check out our new paper to find out!
www.sciencedirect.com/science/arti...
Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social
+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs