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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
5.4K followers 1.7K following 700 posts
Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Lara Bareis, Nils Johnsson and colleagues identify a short linear motif, conserved from yeast to human, that directs proteins to the cell cortex by binding to the Spa2 family of scaffold proteins.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that the FRM binds as a helix into the hydrophobic pocket of SHD1.
January 15, 2026 at 9:38 AM
jcellsci.bsky.social
In their Review, Rahul Kumar Verma, Somya Madan and Richa Rikhy discuss mitochondrial dynamics and signalling in stem cell differentiation.
journals.biologists.com/jcs/article/...
Schematic showing interaction of mitochondrial fusion with Notch signaling. (A) Mouse embryonic stem cells (ESCs) have fragmented mitochondria and active Notch signaling. The Notch intracellular domain (NICD) accumulates in the nucleus, where it regulates CBF1-dependent transcription, resulting in maintenance of fragmented mitochondria. Increased capacitative Ca2+ entry and calcineurin A (CnA) activity stimulate Notch1 signaling, maintaining the stem cell state. During differentiation of ESCs into cardiomyocytes, Notch signaling is reduced, which is accompanied by mitochondrial fusion due to increased expression of the fusion proteins Opa1, Mfn1 and Mfn2 (Mfn1/2). (B) Drosophila neural stem cells (NSCs) have fused mitochondria and active Notch signaling. Increased NICD in the nucleus results in Suppressor of Hairless [Su(H)]-mediated transcription and increased Opa1 and Marf expression. Opa1 and Marf maintain fused mitochondria and support the formation of intermediate progenitor cells. Created in BioRender by Rikhy, R., 2025. https://BioRender.com/wqklpid. This figure was sublicensed under CC-BY 4.0 terms.
January 14, 2026 at 10:34 AM
jcellsci.bsky.social
Isadonna Tengganu and Ke Hu develop transfection and ExM protocols for Chromera velia, enabling direct comparisons with its parasitic apicomplexan relative, Toxoplasma gondi.
journals.biologists.com/jcs/article/...
Comparison of the cytoskeletal architectures of Toxoplasma and Chromera flagellates using ExM.
January 13, 2026 at 9:53 AM
jcellsci.bsky.social
New JCS snapshot - Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation

Anne Müsch presents the key findings from their recent JCS paper with David Cohen and Francisco Lázaro-Diéguez.
journals.biologists.com/jcs/article/...
JCS snapshot - Bile canaliculi formation is dependent on ECM–cell-cell junctional crosstalk.
YouTube video by The Company of Biologists
youtu.be
January 12, 2026 at 4:17 PM
jcellsci.bsky.social
Don't miss the early-bird deadline for our Imaging Cell Dynamics meeting taking place in Catalonia, Spain in May.
Early-bird deadline: Friday 16 January
View the preliminary programme here: www.biologists.com/wp-content/u...
#JCSImaging
January 12, 2026 at 10:38 AM
jcellsci.bsky.social
Our latest interview is with Mole, a long-term contributor to our Sticky Wicket series in JCS. We chat to Mole about being a group leader, the challenges of the academic science system, advice for junior scientists and ‘tea’ recommendations.
journals.biologists.com/jcs/article/...
A sketch of an anthropomorphised Mole with a big grin within a picture frame with the text, ‘Mole’. In the background, is a sketch of a teapot with a smiling face and boots sitting within a similar picture frame. The drawing is signed by the artist, Pete Jeffs.
January 12, 2026 at 10:08 AM
jcellsci.bsky.social
Takuya Norizuki, Yasuharu Kushida, Nobuo Noda, Ken Sato, Miyuki Sato and colleagues identify ALLO-1a as a ubiquitin-binding adaptor for allophagy in C. elegans.
journals.biologists.com/jcs/article/...
Figure showing that ALLO-1a interacts with polyubiquitin.
January 9, 2026 at 2:32 PM
Reposted by Journal of Cell Science
amjeve.uk
If you're looking for a quick and light-hearted weekend read I'd recommend 'An interview with Mole' in @jcellsci.bsky.social!

#biologists100

doi.org/10.1242/jcs....
A cartoon drawing of 'Mole' in a picture frame. Artwork by Pete Jeffs – www.peterjeffsart.com
January 9, 2026 at 11:47 AM
jcellsci.bsky.social
Julie Nielsen, Richard Treisman and colleagues @crick.ac.uk find that MRTFs link cytoskeletal dynamics to cell cycle progression.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that inhibition of contractility in WT cells induces a phenotype similar to MRTF inactivation.
January 9, 2026 at 9:25 AM
Reposted by Journal of Cell Science
biologists.bsky.social
Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb.
More at: www.biologists.com/about-us/wor...
Work for us
Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...
www.biologists.com
January 9, 2026 at 7:39 AM
jcellsci.bsky.social
@gautamdey.bsky.social, @fritzlaylin.bsky.social, @alebenoit.bsky.social and @eelcotromer.bsky.social discuss how the field of evolutionary cell biology works to understand how cells evolve & diversify, highlighting current challenges & the future outlook.
journals.biologists.com/jcs/article/...
Cartoon showing key challenges in evolutionary cell biology. This schematic illustrates four central challenges in the field: (1) integrating cell biology with evolutionary theory and experimental evolution, (2) bridging the genotype–phenotype gap, (3) identifying and developing new model systems, and (4) incorporating ecological context into evolutionary cell biology. Each quadrant highlights a conceptual hurdle that must be addressed to advance the discipline.
January 8, 2026 at 2:00 PM
jcellsci.bsky.social
Julia Roberts, Phuoc Huynh, Luis Carale and Alexandra Whiteley @alexwhiteley.bsky.social discover that UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that PEG10 gag-pol degradation is dependent on the ubiquitin–proteasome system and autophagy
January 8, 2026 at 10:12 AM
Reposted by Journal of Cell Science
kkostova.bsky.social
Honored to be featured in @jcellsci.bsky.social Cell Scientist to Watch series. Grateful to the editors and the many colleagues and trainees who make our work on ribosome quality control possible. Read more: journals.biologists.com/jcs/article/...
Cell scientist to watch – Kamena Kostova
ABSTRACT. Kamena Kostova is an Assistant Investigator at the Stowers Institute for Medical Research (Missouri, USA). Originally from Bulgaria, she moved to the United States to pursue a B.S. in Biolog...
journals.biologists.com
January 7, 2026 at 5:35 PM
jcellsci.bsky.social
Our latest ‘Cell Scientist to Watch’ interview is with Kamena Kostova @kkostova.bsky.social @stowersinstitute.bsky.social. We learn about Kamena's career path, her research, her approach to building a productive & inclusive lab culture & her love of baking.
journals.biologists.com/jcs/article/...
Kamena Kostova
January 7, 2026 at 2:00 PM
jcellsci.bsky.social
Saurabh Shrivastva, Anita Roy and colleagues find that non-muscle myosin IIA and IIB differentially affect the traffic and signalling of the thrombopoietin receptor.
journals.biologists.com/jcs/article/...
Figure showing NMIIA affects anterograde traffic of TpoR–GFP-containing vesicles.
January 7, 2026 at 8:39 AM
Reposted by Journal of Cell Science
biologists.bsky.social
Early-bird deadline to join @jcellsci.bsky.social at their meeting on Imaging Cell Dynamics in Spain in May is Friday 16 January. Apply to attend at:
biologists.com/meetings/jcs...
#JCSimaging
January 6, 2026 at 12:07 PM
jcellsci.bsky.social
In their Opinion article, Makoto Kanzaki and Gwyn Gould re-exam the model of GLUT4 trafficking fat and muscle cells based on new studies suggesting that heterotypic fusion with endosomes might play a more important role than previously realised.
journals.biologists.com/jcs/article/...
Schematic of fusion-guided GLUT4 entry. (A) Insulin or exercise stimulation initiates a trafficking mechanism termed fusion-guided GLUT4 entry (1, FGG4E), whereby IRVs undergo heterotypic fusion with TfR-positive endosomal recycling compartments (ERC) near the TGN- or ERGIC-like regions. This fusion enables GLUT4 to enter the dynamic recycling endosomal system, where it adopts TfR-like motility and undergoes repeated rounds of trafficking to the PM (2, Traffic). Notably, as long as insulin stimulation persists, GLUT4 remains in this dynamic endosomal loop (3, Recycle) and does not return to its original storage pool, suggesting an active mechanism that prevents retrograde retrieval. (B) Upon cessation of insulin stimulation, GLUT4 is extracted from the recycling pathway through a sortilin- and retromer complex-dependent retrograde trafficking process. This leads to its transient entry into the golgin-97 (also known as GOLGA1)- and golgin-245 (also known as GOLGA4)-positive TGN, where it is transiently retained and subsequently re-packaged into IRVs. Under basal conditions, GLUT4 is statically sequestered via AS160-dependent mechanisms, remaining in a primed state for the next stimulus. Together, both panels illustrate a reversible cycle of GLUT4 trafficking regulated by stimulus-dependent fusion entry and retrograde resetting, balancing dynamic integration with stable retention. Note: this figure emphasizes the TGN-based retrograde trafficking pathway of GLUT4, which is directly supported by our observations involving sortilin, retromer, and golgin-97 and -245, and indicates that the GLUT4 vesicle biogenesis system is enhanced upon differentiation. Nevertheless, we do not exclude the possibility that GLUT4 might also traffic through ERGIC-associated compartments, as suggested by previous studies.
January 6, 2026 at 4:37 PM
jcellsci.bsky.social
Issue 24 is complete

Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews.

Explore our ToC: journals.biologists.com/jcs/issue/13...
JCS cover: Marking the end of The Company of Biologists' 100-year anniversary, the final journal cover of 2025 features members of our community, including our academic and guest Editors, our FocalPlane Advisory Board, some of the ‘First Person’ and ‘Cell Scientists to Watch’ scientists featured this year, and our in-house team of administrators and editors at our editorial office in Cambridge.
January 6, 2026 at 10:49 AM
jcellsci.bsky.social
Susan Arden, Folma Buss & team use proximity labelling & quantitative proteomics to define the MYO1E & MYO1F interactomes, revealing shared & unique binding partners.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing recruitment of MYO1F and adaptor proteins to the phagocytic cup.
December 31, 2025 at 10:22 AM
jcellsci.bsky.social
Birendra Kumar Shrestha, Terje Johansen @terjejohansen.bsky.social & team uncover a C-terminal cytoplasmic retention motif and nuclear localization signal that regulate nuclear import of TP53INP2.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Figure and model showing that starvation induced TP53INP2 mRNA stabilization is mediated by demethylase FTO.
December 30, 2025 at 12:37 PM
jcellsci.bsky.social
Kaneez Fatima, Svetlana Konovalova and colleagues find that ribosome-binding protein 1 maintains peroxisome biogenesis.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Figure showing that RRBP1 does not localize to peroxisomes.
December 29, 2025 at 11:03 AM
Reposted by Journal of Cell Science
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Sign up to our content alerts and receive the latest articles in @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social, @dmmjournal.bsky.social and/or @biologyopen.bsky.social direct to your inbox. Find out more at journals.biologists.com/dev/pages/al...
December 26, 2025 at 1:42 PM
jcellsci.bsky.social
Xiaofei Li, Adam Kwiatkowski @kwiatkowskilab.bsky.social, Glenn Radice and colleagues discover that vinculin Y822 phosphorylation regulates adhesion remodelling during cardiomyocyte maturation.
journals.biologists.com/jcs/article/...
Figure showing that Y822 phosphorylation regulates VCL recruitment to cell-cell contacts in cultured CMs.
December 24, 2025 at 12:31 PM
jcellsci.bsky.social
In their Tools and Resources article, Ryosuke Nishimura, Pakorn Kanchanawong and colleagues @mbisg.bsky.social use light-inducible dimerisation to illuminate the role of talin in cell adhesion.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
December 23, 2025 at 2:30 PM
Reposted by Journal of Cell Science
yalembb.bsky.social
Read Lily Kabeche's interview in the Journal of Cell Science about her career path and mentoring philosophy: journals.biologists.com/jcs/article/...
December 22, 2025 at 4:35 PM