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jcellsci.bsky.social
Journal of Cell Science
@jcellsci.bsky.social
5.4K followers 1.7K following 690 posts
Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio
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jcellsci.bsky.social
Takuya Norizuki, Yasuharu Kushida, Nobuo Noda, Ken Sato, Miyuki Sato and colleagues identify ALLO-1a as a ubiquitin-binding adaptor for allophagy in C. elegans.
journals.biologists.com/jcs/article/...
Figure showing that ALLO-1a interacts with polyubiquitin.
January 9, 2026 at 2:32 PM
Reposted by Journal of Cell Science
amjeve.uk
If you're looking for a quick and light-hearted weekend read I'd recommend 'An interview with Mole' in @jcellsci.bsky.social!

#biologists100

doi.org/10.1242/jcs....
A cartoon drawing of 'Mole' in a picture frame. Artwork by Pete Jeffs – www.peterjeffsart.com
January 9, 2026 at 11:47 AM
jcellsci.bsky.social
Julie Nielsen, Richard Treisman and colleagues @crick.ac.uk find that MRTFs link cytoskeletal dynamics to cell cycle progression.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that inhibition of contractility in WT cells induces a phenotype similar to MRTF inactivation.
January 9, 2026 at 9:25 AM
Reposted by Journal of Cell Science
biologists.bsky.social
Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb.
More at: www.biologists.com/about-us/wor...
Work for us
Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...
www.biologists.com
January 9, 2026 at 7:39 AM
jcellsci.bsky.social
@gautamdey.bsky.social, @fritzlaylin.bsky.social, @alebenoit.bsky.social and @eelcotromer.bsky.social discuss how the field of evolutionary cell biology works to understand how cells evolve & diversify, highlighting current challenges & the future outlook.
journals.biologists.com/jcs/article/...
Cartoon showing key challenges in evolutionary cell biology. This schematic illustrates four central challenges in the field: (1) integrating cell biology with evolutionary theory and experimental evolution, (2) bridging the genotype–phenotype gap, (3) identifying and developing new model systems, and (4) incorporating ecological context into evolutionary cell biology. Each quadrant highlights a conceptual hurdle that must be addressed to advance the discipline.
January 8, 2026 at 2:00 PM
jcellsci.bsky.social
Julia Roberts, Phuoc Huynh, Luis Carale and Alexandra Whiteley @alexwhiteley.bsky.social discover that UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing that PEG10 gag-pol degradation is dependent on the ubiquitin–proteasome system and autophagy
January 8, 2026 at 10:12 AM
Reposted by Journal of Cell Science
kkostova.bsky.social
Honored to be featured in @jcellsci.bsky.social Cell Scientist to Watch series. Grateful to the editors and the many colleagues and trainees who make our work on ribosome quality control possible. Read more: journals.biologists.com/jcs/article/...
Cell scientist to watch – Kamena Kostova
ABSTRACT. Kamena Kostova is an Assistant Investigator at the Stowers Institute for Medical Research (Missouri, USA). Originally from Bulgaria, she moved to the United States to pursue a B.S. in Biolog...
journals.biologists.com
January 7, 2026 at 5:35 PM
jcellsci.bsky.social
Our latest ‘Cell Scientist to Watch’ interview is with Kamena Kostova @kkostova.bsky.social @stowersinstitute.bsky.social. We learn about Kamena's career path, her research, her approach to building a productive & inclusive lab culture & her love of baking.
journals.biologists.com/jcs/article/...
Kamena Kostova
January 7, 2026 at 2:00 PM
jcellsci.bsky.social
Saurabh Shrivastva, Anita Roy and colleagues find that non-muscle myosin IIA and IIB differentially affect the traffic and signalling of the thrombopoietin receptor.
journals.biologists.com/jcs/article/...
Figure showing NMIIA affects anterograde traffic of TpoR–GFP-containing vesicles.
January 7, 2026 at 8:39 AM
Reposted by Journal of Cell Science
biologists.bsky.social
Early-bird deadline to join @jcellsci.bsky.social at their meeting on Imaging Cell Dynamics in Spain in May is Friday 16 January. Apply to attend at:
biologists.com/meetings/jcs...
#JCSimaging
January 6, 2026 at 12:07 PM
jcellsci.bsky.social
In their Opinion article, Makoto Kanzaki and Gwyn Gould re-exam the model of GLUT4 trafficking fat and muscle cells based on new studies suggesting that heterotypic fusion with endosomes might play a more important role than previously realised.
journals.biologists.com/jcs/article/...
Schematic of fusion-guided GLUT4 entry. (A) Insulin or exercise stimulation initiates a trafficking mechanism termed fusion-guided GLUT4 entry (1, FGG4E), whereby IRVs undergo heterotypic fusion with TfR-positive endosomal recycling compartments (ERC) near the TGN- or ERGIC-like regions. This fusion enables GLUT4 to enter the dynamic recycling endosomal system, where it adopts TfR-like motility and undergoes repeated rounds of trafficking to the PM (2, Traffic). Notably, as long as insulin stimulation persists, GLUT4 remains in this dynamic endosomal loop (3, Recycle) and does not return to its original storage pool, suggesting an active mechanism that prevents retrograde retrieval. (B) Upon cessation of insulin stimulation, GLUT4 is extracted from the recycling pathway through a sortilin- and retromer complex-dependent retrograde trafficking process. This leads to its transient entry into the golgin-97 (also known as GOLGA1)- and golgin-245 (also known as GOLGA4)-positive TGN, where it is transiently retained and subsequently re-packaged into IRVs. Under basal conditions, GLUT4 is statically sequestered via AS160-dependent mechanisms, remaining in a primed state for the next stimulus. Together, both panels illustrate a reversible cycle of GLUT4 trafficking regulated by stimulus-dependent fusion entry and retrograde resetting, balancing dynamic integration with stable retention. Note: this figure emphasizes the TGN-based retrograde trafficking pathway of GLUT4, which is directly supported by our observations involving sortilin, retromer, and golgin-97 and -245, and indicates that the GLUT4 vesicle biogenesis system is enhanced upon differentiation. Nevertheless, we do not exclude the possibility that GLUT4 might also traffic through ERGIC-associated compartments, as suggested by previous studies.
January 6, 2026 at 4:37 PM
jcellsci.bsky.social
Issue 24 is complete

Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews.

Explore our ToC: journals.biologists.com/jcs/issue/13...
JCS cover: Marking the end of The Company of Biologists' 100-year anniversary, the final journal cover of 2025 features members of our community, including our academic and guest Editors, our FocalPlane Advisory Board, some of the ‘First Person’ and ‘Cell Scientists to Watch’ scientists featured this year, and our in-house team of administrators and editors at our editorial office in Cambridge.
January 6, 2026 at 10:49 AM
jcellsci.bsky.social
Susan Arden, Folma Buss & team use proximity labelling & quantitative proteomics to define the MYO1E & MYO1F interactomes, revealing shared & unique binding partners.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Figure showing recruitment of MYO1F and adaptor proteins to the phagocytic cup.
December 31, 2025 at 10:22 AM
jcellsci.bsky.social
Birendra Kumar Shrestha, Terje Johansen @terjejohansen.bsky.social & team uncover a C-terminal cytoplasmic retention motif and nuclear localization signal that regulate nuclear import of TP53INP2.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Figure and model showing that starvation induced TP53INP2 mRNA stabilization is mediated by demethylase FTO.
December 30, 2025 at 12:37 PM
jcellsci.bsky.social
Kaneez Fatima, Svetlana Konovalova and colleagues find that ribosome-binding protein 1 maintains peroxisome biogenesis.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Figure showing that RRBP1 does not localize to peroxisomes.
December 29, 2025 at 11:03 AM
Reposted by Journal of Cell Science
biologists.bsky.social
Sign up to our content alerts and receive the latest articles in @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social, @dmmjournal.bsky.social and/or @biologyopen.bsky.social direct to your inbox. Find out more at journals.biologists.com/dev/pages/al...
December 26, 2025 at 1:42 PM
jcellsci.bsky.social
Xiaofei Li, Adam Kwiatkowski @kwiatkowskilab.bsky.social, Glenn Radice and colleagues discover that vinculin Y822 phosphorylation regulates adhesion remodelling during cardiomyocyte maturation.
journals.biologists.com/jcs/article/...
Figure showing that Y822 phosphorylation regulates VCL recruitment to cell-cell contacts in cultured CMs.
December 24, 2025 at 12:31 PM
jcellsci.bsky.social
In their Tools and Resources article, Ryosuke Nishimura, Pakorn Kanchanawong and colleagues @mbisg.bsky.social use light-inducible dimerisation to illuminate the role of talin in cell adhesion.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
December 23, 2025 at 2:30 PM
Reposted by Journal of Cell Science
yalembb.bsky.social
Read Lily Kabeche's interview in the Journal of Cell Science about her career path and mentoring philosophy: journals.biologists.com/jcs/article/...
December 22, 2025 at 4:35 PM
Reposted by Journal of Cell Science
terjejohansen.bsky.social
A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2 url: journals.biologists.com/jcs/article/...
BIG Congratulations to all authors and particularly to the first author Birendra Kumar Shrestha who did a fantastic job !
A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2
Highlighted Article: The transcriptional coactivator TP53INP2 is degraded by nuclear proteasomes under basal conditions. Upon starvation and exposure to various chemical stressors, a conserved cytopla...
journals.biologists.com
December 19, 2025 at 11:38 AM
jcellsci.bsky.social
In their Editorial, Claire Moulton, Amelia Glazier and Katie Ward look back on an extraordinary year, as @biologists.bsky.social celebrated their 100-year anniversary.

journals.biologists.com/jcs/article/...
The winning microscopy images from the Node–FocalPlane image competition, held at the Biologists @ 100 conference in March 2025. Left, ‘Cell-estial bloom’, the first-place winner, from Özge Özgüç, showing a live human induced pluripotent stem cell (hiPSC) colony labelled for lamin B, marking the nuclear lamina. Centre, ‘Dancing actinotroch’, the second-place image, from Allan Carrillo-Baltodano, showing an actinotroch larva of a phoronid worm, stained for actin (phalloidin, yellow) and acetylated tubulin (magenta). Right, ‘Who's active?’, the third-place image, from Julia Peloggia de Castro, depicting a lateral view of a zebrafish embryo at 9 h post fertilisation. MitoTracker was used to stain active mitochondria (magenta to yellow intensity scale), and an EGFP transgenic tag marks cell membranes (cyan).
December 22, 2025 at 3:00 PM
Reposted by Journal of Cell Science
drmichaelway.bsky.social
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
At the helm of JCS – Editors-in-Chief past, present… and future
The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...
doi.org
December 22, 2025 at 10:33 AM
Reposted by Journal of Cell Science
peiferlabunc.bsky.social
I'm on the Board of @biologists.bsky.social. Many know them as publishers of @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social , DMM, and @biologyopen.bsky.social --but they also are a major funder of small grants that empower young biologists and enable scientific meetings 🧪
biologists.bsky.social The Company of Biologists @biologists.bsky.social · 21d
We believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
Supporting early-career researchers
On these pages we highlight the range of resources that we offer to early-career researchers.
www.biologists.com
December 22, 2025 at 12:26 PM
Reposted by Journal of Cell Science
gautamdey.bsky.social
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍

W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social

journals.biologists.com/jcs/article/...
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
December 19, 2025 at 4:13 PM
jcellsci.bsky.social
Paola Molina, Ian Macara and colleagues discover that non-canonical EGFR signalling promotes MAPK-dependent extrusion of epithelial cells.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 19, 2025 at 3:07 PM