Rosana Collepardo
@rcollepardo.bsky.social
Professor of Computational and Molecular Biophysics at Cambridge University. We work on multiscale modeling of chromatin and biomolecular condensates. From Mexico City 🇲🇽. Mum of two (She/Her)
Pinned
What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties?
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
November 18, 2025 at 3:07 PM
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
Many thanks to @jojdavies.bsky.social for inviting us to take part in this exciting study, combining MCC ultra with simulations to explore how the biophysical properties of chromatin govern its structure in living cells.
Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social
Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 7, 2025 at 8:19 AM
Many thanks to @jojdavies.bsky.social for inviting us to take part in this exciting study, combining MCC ultra with simulations to explore how the biophysical properties of chromatin govern its structure in living cells.
Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social
Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social
Check out our new work, led by talented @janhuemar.bsky.social, where we uncover that pioneer factor Oct4 remodels chromatin for DNA access not by opening it but by exploiting nucleosome breathing and forming clusters 🔥🔥🔥
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
October 22, 2025 at 5:10 AM
Check out our new work, led by talented @janhuemar.bsky.social, where we uncover that pioneer factor Oct4 remodels chromatin for DNA access not by opening it but by exploiting nucleosome breathing and forming clusters 🔥🔥🔥
🚨 New paper out in Nature Comms!
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
Nucleosome spacing can fine-tune higher-order chromatin assembly - Nature Communications
Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...
www.nature.com
September 3, 2025 at 12:00 PM
We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥
If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding
Simulations by superstar @juliamaristany.bsky.social
If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding
Simulations by superstar @juliamaristany.bsky.social
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
September 3, 2025 at 11:59 AM
We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥
If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding
Simulations by superstar @juliamaristany.bsky.social
If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding
Simulations by superstar @juliamaristany.bsky.social
It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️
Wonderful to be back in Cambridge for a PhD viva
Thanks @rcollepardo.bsky.social and Aleks Reinhardt for inviting me and for letting me stay at Trinity while my old college St John’s was having their May Ball
Thanks @rcollepardo.bsky.social and Aleks Reinhardt for inviting me and for letting me stay at Trinity while my old college St John’s was having their May Ball
June 27, 2025 at 5:56 AM
It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️
Reposted by Rosana Collepardo
So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...
doi.org
May 6, 2025 at 2:58 PM
So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin
Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
March 7, 2025 at 11:09 AM
In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin
Reposted by Rosana Collepardo
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/
Assistant/Associate Professor in Computational Biology - Job Opportunities - University of Cambridge
Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.
www.jobs.cam.ac.uk
February 21, 2025 at 3:07 PM
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/
To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social
February 16, 2025 at 12:57 AM
To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social
María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social
February 16, 2025 at 12:32 AM
María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social
Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social
February 16, 2025 at 12:01 AM
Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social
Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 11:36 PM
Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social
Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 11:06 PM
Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social
Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 10:38 PM
Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social
Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 10:06 PM
Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social
First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 9:39 PM
First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social
Starting now #BPS2025 @mgo-bps.bsky.social
February 15, 2025 at 9:37 PM
Starting now #BPS2025 @mgo-bps.bsky.social
Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.
TODAY at 1:30 pm
TODAY at 1:30 pm
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
February 15, 2025 at 6:44 PM
Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.
TODAY at 1:30 pm
TODAY at 1:30 pm
Reposted by Rosana Collepardo
Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...
Disrupting droplets
Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.
elifesciences.org
February 15, 2025 at 2:00 AM
Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...
Reposted by Rosana Collepardo
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
February 15, 2025 at 3:14 PM
Introducing Mpipi-Recharged🔥🔥🔥
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates
Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...
pubs.acs.org
February 11, 2025 at 1:31 PM
Introducing Mpipi-Recharged🔥🔥🔥
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly
pubs.acs.org/doi/10.1021/...
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
February 7, 2025 at 10:33 AM
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Don't miss these two super exciting talks on chromatin tomorrow at 5pm UK time!
Zoom link below
This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)
Zoom link below
This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)
Friendly reminder of our webinar next Tuesday!
See you all there!
See you all there!
The Multiscale Genome Organisation is now on Bluesky!
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
January 27, 2025 at 12:15 PM
Don't miss these two super exciting talks on chromatin tomorrow at 5pm UK time!
Zoom link below
This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)
Zoom link below
This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)
Reposted by Rosana Collepardo
📢 Join us! We are recruiting an Associate Professor/Professor of Molecular and Cellular Biology to join our innovative research community!
Find out more about the position and apply: https://buff.ly/4iYDBjv
Find out more about the position and apply: https://buff.ly/4iYDBjv
January 10, 2025 at 12:00 PM
📢 Join us! We are recruiting an Associate Professor/Professor of Molecular and Cellular Biology to join our innovative research community!
Find out more about the position and apply: https://buff.ly/4iYDBjv
Find out more about the position and apply: https://buff.ly/4iYDBjv