Lightnews — Scholar-powered news

Rosana Collepardo @rcollepardo.bsky.social · Sep 3

Julia Maristany @juliamaristany.bsky.social · Jul 10

🚨 New paper out in Nature Comms!

From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.

👇 A short thread on how physical #genome organization emerges from molecular interactions:

www.nature.com/articles/s41...

Nucleosome spacing can fine-tune higher-order chromatin assembly - Nature Communications

Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...

www.nature.com

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Rosana Collepardo @rcollepardo.bsky.social · Sep 3

We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥

If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding

Simulations by superstar @juliamaristany.bsky.social

Gerlich Lab @gerlichlab.bsky.social · Sep 3

1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...

An electrostatic repulsion model of centromere organisation

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

doi.org

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Rosana Collepardo @rcollepardo.bsky.social · Jun 27

It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jun 26

Wonderful to be back in Cambridge for a PhD viva

Thanks @rcollepardo.bsky.social and Aleks Reinhardt for inviting me and for letting me stay at Trinity while my old college St John’s was having their May Ball

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Reposted by Rosana Collepardo

Janet Kumita @jrkumita.bsky.social · May 6

So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...

doi.org

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Rosana Collepardo @rcollepardo.bsky.social · Mar 7

In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Mar 7

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

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Rosana Collepardo @rcollepardo.bsky.social · Mar 7

Looks amazing!! Congratulations 🔥🔥🔥

Reposted by Rosana Collepardo

Aylwyn Scally @aylwyn-scally.bsky.social · Feb 21

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

Assistant/Associate Professor in Computational Biology - Job Opportunities - University of Cambridge

Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.

www.jobs.cam.ac.uk

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Rosana Collepardo @rcollepardo.bsky.social · Feb 16

To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 16

María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 16

Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Starting now #BPS2025 @mgo-bps.bsky.social

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Rosana Collepardo @rcollepardo.bsky.social · Feb 15

Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.

TODAY at 1:30 pm

Rosana Collepardo @rcollepardo.bsky.social · Feb 7

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

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Reposted by Rosana Collepardo

Jerelle Joseph @jerelleaj.bsky.social · Feb 15

Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...

Disrupting droplets

Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.

elifesciences.org

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Reposted by Rosana Collepardo

Jan Huertas @janhuemar.bsky.social · Feb 15

Are you in #BPS2025?

Come to join us at the MGO Symposium this afternoon!

Rosana Collepardo @rcollepardo.bsky.social · Feb 7

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

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Rosana Collepardo @rcollepardo.bsky.social · Feb 11

Thanks to the support of HECBIOSIM for enabling all our simulations www.hecbiosim.ac.uk 🙌🙌🙌

Home

Helping computational biologists gain access and scaling up to national level High-End Computing (HEC) resources.

www.hecbiosim.ac.uk

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Rosana Collepardo @rcollepardo.bsky.social · Feb 11

Introducing Mpipi-Recharged🔥🔥🔥

Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly

pubs.acs.org/doi/10.1021/...

Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates

Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...

pubs.acs.org

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Rosana Collepardo @rcollepardo.bsky.social · Feb 7

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

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Rosana Collepardo @rcollepardo.bsky.social · Feb 7

It should've been #BPS2025

Rosana Collepardo @rcollepardo.bsky.social · Jan 27

Don't miss these two super exciting talks on chromatin tomorrow at 5pm UK time!

Zoom link below

This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)

Multiscale Genome Organisation @mgo-bps.bsky.social · Jan 24

Friendly reminder of our webinar next Tuesday!

See you all there!

Multiscale Genome Organisation @mgo-bps.bsky.social · Jan 20

The Multiscale Genome Organisation is now on Bluesky!

Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!

Link:
mit.zoom.us/j/91715298970

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Reposted by Rosana Collepardo

School of Biological Sciences @cambridgebiosci.bsky.social · Jan 10

📢 Join us! We are recruiting an Associate Professor/Professor of Molecular and Cellular Biology to join our innovative research community!

Find out more about the position and apply: https://buff.ly/4iYDBjv

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