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Reposted by Jan Huertas

Gerlich Lab @gerlichlab.bsky.social · Sep 3

1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...

An electrostatic repulsion model of centromere organisation

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

doi.org

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Reposted by Jan Huertas

Julia Maristany @juliamaristany.bsky.social · Jul 10

🚨 New paper out in Nature Comms!

From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.

👇 A short thread on how physical #genome organization emerges from molecular interactions:

www.nature.com/articles/s41...

Nucleosome spacing can fine-tune higher-order chromatin assembly - Nature Communications

Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...

www.nature.com

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Reposted by Jan Huertas

Janet Kumita @jrkumita.bsky.social · May 6

So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...

doi.org

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Reposted by Jan Huertas

FragileNucleosome @fnucleosome.bsky.social · Mar 23

🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...

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Jan Huertas @janhuemar.bsky.social · Mar 7

Excited to share our newest collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social, where we show that H1 acts as a liquid-like glue in chromatin.
Go check the paper on the biorXiv!

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Mar 7

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

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Reposted by Jan Huertas

Miguel Montez @miguelmontez.bsky.social · Feb 21

We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.

⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...

Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC

Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....

www.biorxiv.org

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Reposted by Jan Huertas

Jerelle Joseph @jerelleaj.bsky.social · Feb 15

Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...

Disrupting droplets

Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.

elifesciences.org

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Jan Huertas @janhuemar.bsky.social · Feb 15

Are you in #BPS2025?

Come to join us at the MGO Symposium this afternoon!

Rosana Collepardo @rcollepardo.bsky.social · Feb 7

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

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Reposted by Jan Huertas

Rosana Collepardo @rcollepardo.bsky.social · Feb 7

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

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Jan Huertas @janhuemar.bsky.social · Jan 23

Thanks a lot Srinjan!

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