Pierre Genevaux
@genevauxpierre.bsky.social
Toxin-Antitoxin Systems, Molecular Chaperones, group leader CNRS Toulouse
Reposted by Pierre Genevaux
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Reposted by Pierre Genevaux
Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5
academic.oup.com/nar/article/... 1/5
Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons
Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti
academic.oup.com
November 17, 2025 at 3:44 PM
Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5
academic.oup.com/nar/article/... 1/5
Reposted by Pierre Genevaux
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
The type VI secretion system and associated effector proteins - Nature Reviews Microbiology
In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...
nature.com
November 17, 2025 at 10:08 AM
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
#ResultatScientifique🔎| Une toxine capable de bloquer la production de protéines chez M. tuberculosis ouvre de nouvelles pistes contre les souches multirésistantes 🦠
🤝 @cnrs.fr @cbitoulouse.bsky.social
✍️ Pierre Genevaux
📕 @narjournal.bsky.social |
🤝 @cnrs.fr @cbitoulouse.bsky.social
✍️ Pierre Genevaux
📕 @narjournal.bsky.social |
Quand la bactérie responsable de la tuberculose fabrique son propre poison
Mycobacterium tuberculosis, la bactérie responsable de la tuberculose, produit des paires de poison-antidote, appelées « Toxi
buff.ly
November 18, 2025 at 3:11 PM
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
November 17, 2025 at 10:31 AM
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Reposted by Pierre Genevaux
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Reposted by Pierre Genevaux
JOB OFFER #PhageSky
We have a postdoc position opening in my group to investigate phage-MGE interactions !
We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social
Contact me for more info !
>> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
We have a postdoc position opening in my group to investigate phage-MGE interactions !
We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social
Contact me for more info !
>> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher Microbiology (M/F)
emploi.cnrs.fr
October 22, 2025 at 9:35 AM
JOB OFFER #PhageSky
We have a postdoc position opening in my group to investigate phage-MGE interactions !
We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social
Contact me for more info !
>> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
We have a postdoc position opening in my group to investigate phage-MGE interactions !
We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social
Contact me for more info !
>> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
Reposted by Pierre Genevaux
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Pierre Genevaux
Reposted by Pierre Genevaux
Really excited to share our resource and analysis of AlphaFold-predicted monomers and homodimers across viruses and phages. Project driven by fab PhD student @rodai.bsky.social and with our great collaborators Joana Pereira @joanampereira.bsky.social and @ninjani.bsky.social
The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes https://www.biorxiv.org/content/10.1101/2025.05.14.653371v1
May 19, 2025 at 6:37 AM
Really excited to share our resource and analysis of AlphaFold-predicted monomers and homodimers across viruses and phages. Project driven by fab PhD student @rodai.bsky.social and with our great collaborators Joana Pereira @joanampereira.bsky.social and @ninjani.bsky.social
Reposted by Pierre Genevaux
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
May 18, 2025 at 3:20 PM
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
Reposted by Pierre Genevaux
🚨 PhD opportunity in Toulouse!
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.
📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social
#StructuralBiology #MicroSky
More details 👇
shorturl.at/OaVMI
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.
📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social
#StructuralBiology #MicroSky
More details 👇
shorturl.at/OaVMI
PhD position in structural biology and infectious diseases - IPBS-Toulouse
We are currently looking for highly motivated PhD student with a strong interest in structural[…]
shorturl.at
May 17, 2025 at 6:21 AM
🚨 PhD opportunity in Toulouse!
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.
📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social
#StructuralBiology #MicroSky
More details 👇
shorturl.at/OaVMI
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.
📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social
#StructuralBiology #MicroSky
More details 👇
shorturl.at/OaVMI
Reposted by Pierre Genevaux
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 8, 2025 at 8:27 PM
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Reposted by Pierre Genevaux
📖 New publication from the TacC team at MMSB!
Congratulations to Nathan Fraikin et al.!
@nfrk92.bsky.social @agathe-couturier.bsky.social
Congratulations to Nathan Fraikin et al.!
@nfrk92.bsky.social @agathe-couturier.bsky.social
Our set of new prokaryote-optimized fluorescent proteins is now published ! #microbiology #microsky #microscopy 🧫🦠🔬
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging
Bright and photostable monomeric fluorescent proteins enable long-term time-lapse imaging in E. coli.
www.science.org
April 24, 2025 at 1:57 PM
📖 New publication from the TacC team at MMSB!
Congratulations to Nathan Fraikin et al.!
@nfrk92.bsky.social @agathe-couturier.bsky.social
Congratulations to Nathan Fraikin et al.!
@nfrk92.bsky.social @agathe-couturier.bsky.social
Reposted by Pierre Genevaux
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
jobs.ncl.ac.uk
April 9, 2025 at 12:29 PM
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Reposted by Pierre Genevaux
Here our new preprint on the LPS holo-translocon doi.org/10.1101/2025... , collaboration with Yves Quentin @JulieMarcoux @fronzeslab.bsky.social @pstansfeld.bsky.social - @cbitoulouse.bsky.social
Structural Basis of Lipopolysaccharide Assembly by the Outer Membrane Translocon Holo-Complex
Lipopolysaccharide (LPS) assembly at the surfaces-exposed leaflet of the bacterial outer membrane (OM) is mediated by the OM LPS translocon. An essential transmembrane beta-barrel protein, LptD, and a...
doi.org
April 11, 2025 at 6:11 AM
Here our new preprint on the LPS holo-translocon doi.org/10.1101/2025... , collaboration with Yves Quentin @JulieMarcoux @fronzeslab.bsky.social @pstansfeld.bsky.social - @cbitoulouse.bsky.social
Reposted by Pierre Genevaux
This international workshop to be held at CBI on the University of Toulouse scientific campus. Our microbiology unit #LMGM is an active partner of the #MIRA network
@polardlab.bsky.social @genevauxpierre.bsky.social @chgjohnston.bsky.social @raffaeleieva.bsky.social @olayarendueles.bsky.social
@polardlab.bsky.social @genevauxpierre.bsky.social @chgjohnston.bsky.social @raffaeleieva.bsky.social @olayarendueles.bsky.social
Don't miss this opportunity to share with our India-France International Research network #IRN on infectious diseases and antimicrobial resistance #MIRA
REGISTRATION is open (free but mandatory)
www.ipbs.fr/mira2025/
REGISTRATION is open (free but mandatory)
www.ipbs.fr/mira2025/
🔎Discover the programme for our Infectious Diseases & Antimicrobial Resistance Workshop!
Programme and details: www.ipbs.fr/mira2025/
Registration form: www.ipbs.fr/mira-worksho...
@isabellesaves.bsky.social @oneyrolles.bsky.social @cnrsbiologie.bsky.social
Programme and details: www.ipbs.fr/mira2025/
Registration form: www.ipbs.fr/mira-worksho...
@isabellesaves.bsky.social @oneyrolles.bsky.social @cnrsbiologie.bsky.social
February 12, 2025 at 3:58 PM
This international workshop to be held at CBI on the University of Toulouse scientific campus. Our microbiology unit #LMGM is an active partner of the #MIRA network
@polardlab.bsky.social @genevauxpierre.bsky.social @chgjohnston.bsky.social @raffaeleieva.bsky.social @olayarendueles.bsky.social
@polardlab.bsky.social @genevauxpierre.bsky.social @chgjohnston.bsky.social @raffaeleieva.bsky.social @olayarendueles.bsky.social
Reposted by Pierre Genevaux
ERC-funded PhD (infection biology) and a Postdoc (genetic engineering) position in my lab. #phagetherapy
March 25, 2025 at 9:58 AM
ERC-funded PhD (infection biology) and a Postdoc (genetic engineering) position in my lab. #phagetherapy
Reposted by Pierre Genevaux
Op 25 maart behandelt de Eerste Kamer de OCW-begroting, inclusief de ongekende bezuinigingen op universiteiten. De gevolgen voor de maatschappij zijn enorm!
Daarom roepen we op: DOE HET NIET! Stop de bezuinigingen op universiteiten! Help jij mee om onze boodschap te verspreiden? #DoeHetNiet ✋⛔
Daarom roepen we op: DOE HET NIET! Stop de bezuinigingen op universiteiten! Help jij mee om onze boodschap te verspreiden? #DoeHetNiet ✋⛔
March 19, 2025 at 9:41 AM
Op 25 maart behandelt de Eerste Kamer de OCW-begroting, inclusief de ongekende bezuinigingen op universiteiten. De gevolgen voor de maatschappij zijn enorm!
Daarom roepen we op: DOE HET NIET! Stop de bezuinigingen op universiteiten! Help jij mee om onze boodschap te verspreiden? #DoeHetNiet ✋⛔
Daarom roepen we op: DOE HET NIET! Stop de bezuinigingen op universiteiten! Help jij mee om onze boodschap te verspreiden? #DoeHetNiet ✋⛔
Reposted by Pierre Genevaux
Reposted by Pierre Genevaux
Americans seem hell-bent on experiencing the struggles that our grandparents worked so hard to eradicate. TB doesn't care about politics, but it thrives on neglect.
#TBResearch #PublicHealth #HistoryRepeating
theconversation.com/as-tuberculo...
#TBResearch #PublicHealth #HistoryRepeating
theconversation.com/as-tuberculo...
As tuberculosis cases rise in the US and worldwide, health officials puzzle over the resurgence of a disease once in decline
Reports of TB date back to the time of Hippocrates, but the Kansas outbreak shows that the ancient disease is very much a modern-day scourge.
theconversation.com
March 14, 2025 at 6:30 PM
Americans seem hell-bent on experiencing the struggles that our grandparents worked so hard to eradicate. TB doesn't care about politics, but it thrives on neglect.
#TBResearch #PublicHealth #HistoryRepeating
theconversation.com/as-tuberculo...
#TBResearch #PublicHealth #HistoryRepeating
theconversation.com/as-tuberculo...
Reposted by Pierre Genevaux
Twists, turns and jumps: T6SS evolution within species
@cp-trendsmicrobiol.bsky.social SpotLight on @naturecomms.bsky.social paper by @tonihabich.bsky.social et al from Daniel Unterweger lab at @mpi-evolbio.bsky.social
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social SpotLight on @naturecomms.bsky.social paper by @tonihabich.bsky.social et al from Daniel Unterweger lab at @mpi-evolbio.bsky.social
www.cell.com/trends/micro...
Twists, turns and jumps: T6SS evolution within species
The type VI secretion system mediates interbacterial antagonism between Gram-negative
bacteria through delivery of toxic effector proteins. A recent comprehensive genomic
analysis by Habich et al. rev...
www.cell.com
March 12, 2025 at 8:07 AM
Twists, turns and jumps: T6SS evolution within species
@cp-trendsmicrobiol.bsky.social SpotLight on @naturecomms.bsky.social paper by @tonihabich.bsky.social et al from Daniel Unterweger lab at @mpi-evolbio.bsky.social
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social SpotLight on @naturecomms.bsky.social paper by @tonihabich.bsky.social et al from Daniel Unterweger lab at @mpi-evolbio.bsky.social
www.cell.com/trends/micro...
Reposted by Pierre Genevaux
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
March 13, 2025 at 6:43 AM
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
Reposted by Pierre Genevaux
Early reports to WHO from the 30 highest #tuberculosis (TB)-burden countries confirm that funding cuts from foreign aid, particularly from USAID, are already dismantling essential TB services.
Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i
Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i
March 6, 2025 at 8:58 AM
Early reports to WHO from the 30 highest #tuberculosis (TB)-burden countries confirm that funding cuts from foreign aid, particularly from USAID, are already dismantling essential TB services.
Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i
Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i