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🧬Jacob L Steenwyk

@jlsteenwyk.bsky.social

7.4K followers 1.9K following 990 posts

Omics & Software Eng 🧬👨🏽‍💻 | UC-Berkeley 🐻👨🏽‍🔬 | Current LSRF HHMI Awardee🎓 | HHMI Gilliam Alumn🧑‍🎓 https://linktr.ee/jlsteenwyk 🔗🌲 jlsteenwyk.com 🔗📍

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · Nov 10

Genomics, evolution, and more starter pack!

Help build community with this starter pack.

This list is currently incomplete. Want to be included? Reply and I will remedy that!
go.bsky.app/JjvzkWU

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 19h

Small models are underrated. Big models like the immensely impressive GPT-5 and Claude Opus/Sonnet will remain useful and major workhorses. But small, cheap, easy-to-fine-tune and deploy small models will have increased utility

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23h

epic

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23h

📈 Trending This Week
Trending topics on Reddit include #llm, #Machinelearning, #Omics, #Transformer, & #Neuralnetworks.

Keep up with Genomely by subscribing for free!
genomely.substack.com

Genomely | 🧬Jacob L Steenwyk | Substack

Where Genomics and Evolution Converge. Click to read Genomely, by 🧬Jacob L Steenwyk, a Substack publication with hundreds of subscribers.

genomely.substack.com

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23h

🧬 Community Insights
- Why are Humans able to get the rabies vaccine after a bite?
- Stanford is updating their Deep Learning course on YouTube
- I want to open my PhD thesis with a Monty Python quote. Talk me out of this!

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23h

🔬 Research Frontiers
- Matthew Shoulders named head of the Department of Chemistry
- Physics Nobel awarded for macro demonstration of quantum effects
- New prediction model could improve the reliability of fusion power plants

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 23h

BioAI Weekly: a newsletter that cuts through the AI hype to deliver what actually matters.

📊 This week: 236 articles analyzed, 51 community posts tracked, 10 trending topics examined

More detail and links to all highlights available here: genomely.substack.com/p/bioai-week...

🧵 Thread below 👇

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 1d

We’ll see what happens

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 1d

Truth

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 1d

Nations w/ 2 laureates include 🇮🇱 (Israel), 🇳🇱 (Netherlands), 🇭🇺 (Hungary), 🇳🇴 (Norway), 🇷🇺 (Russia), 🇦🇷 (Argentina). Nations w/ 1 laureate include 🇮🇳 (India), 🇨🇳 (China), 🇮🇪 (Ireland), 🇳🇿 (New Zealand), 🇵🇹 (Portugal), 🇪🇸 (Spain), 🇱🇧 (Lebanon), and 🇿🇦 (South Africa)

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 1d

Aggregated #Nobel Prize counts for #Physio or #Medicine, 1901-2025

🇺🇸 112 (USA)
🇬🇧 32 (UK)
🇩🇪 17 (Germany)
🇫🇷 11 (France)
🇸🇪 9 (Sweden)
🇨🇭 7 (Switzerland)
🇦🇺 7 (Australia)
🇦🇹 6 (Austria)
🇩🇰 5 (Denmark)
🇯🇵 6 (Japan)
🇨🇦 4 (Canada)
🇧🇪 4 (Belgium)
🇮🇹 3 (Italy)

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 2d

super interesting that two winners were *not* at universities
bsky.app/profile/jlst...

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 2d

🎉 Huge congratulations to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for winning the 2025 #Nobel Prize in Physiology or Medicine for their discoveries in peripheral #immune tolerance! 🧬🛡️

#Nobel2025 #Immunology

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 2d

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 5d

However, challenges remain. #Hallucination remains a problem, hype can exaggerate promise, and verification and synthesis remain #bottlenecks.

Still, the trajectory is clear. AI is speeding up materials #discovery like never before — and may define the next era of #science and #technology

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 5d

The results could reshape industries:
🔋 Batteries that charge in minutes
💻 Semiconductors beyond silicon
🌱 Plastics that recycle themselves
☀️ Catalysts for clean energy

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 5d

Generative AI enables a different approach to materials science. Instead of trial and error, #scientists tell AI what they want (non-toxic, conductive, stable)…and AI generates candidates that fit.

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 5d

“Self-driving labs” powered by #robots and guided w/ #AI run 24/7 experiments. @ucberkeleyofficial.bsky.social A-Lab synthesized 41 new materials in just 17 days.

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 5d

AI isn’t just making text and images anymore. It’s helping invent new #materials!

Google's DeepMind recently predicted millions of new crystals. @microsoft.com and Meta are releasing #generative models for #polymers and #catalysts.

🔗: genomely.substack.com/p/ai-is-desi...

A short 🧵

AI is Designing the Materials of Tomorrow

How AI Is Powering a Materials Revolution

genomely.substack.com

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10d

ngl, im surprised anyone liked this, but i appreciate folks letting me be me lol bsky.app/profile/jlst...

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10d

saturday office vibes are so chill and underrated

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10d

super grateful for the time i get to spend at @futurehousesf.bsky.social working on AI evals

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10d

saturday office vibes are so chill and underrated

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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 11d

🥳🥳🥳

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 11d

Great points! I still appreciate them seeing the value in protein structure prediction (and computational biology)!

Caveats included, we can still celebrate what SimpleFold means for the scientific community

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 12d

Spike in new subscribers because of this post - grateful to everyone who decided to follow along.

I'll be doing a re-introduction post soon to say hi to everyone 👋😄
bsky.app/profile/jlst...

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 12d

if you have any suggestions for new functions, please do not hesitate 😄

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 12d

omg tysm for using PhyKIT 😭🫶