The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...

ICE agents raided a South Shore apartment building overnight as the city braces for a possible military deployment.

Altin et al. identified CxUb, a C-terminally extended ubiquitin molecule dedicated to overcoming stress and present in all eukaryotic genomes. CxUb marks client proteins for efficient degradation by the proteasome, ensuring cellular quality control. CxUb function is critical specifically in stressed cells, safeguarding healthy ones and contributing to healthy aging.

UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map the NMD-regulated human transcriptome, highlighting alternative splicing as a major NMD-activating mechanism.