Schuller Jan
@schullerjm.bsky.social
220 followers 140 following 32 posts
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Schuller Jan @schullerjm.bsky.social · 10d
Really looking forward to it. It's a great opportunity to meet friends and make new ones. We are also excited to present our latest structural work on the methyl branch of methanogens. Unpublished and highly exciting!
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Schuller Jan @schullerjm.bsky.social · 14d
www.nature.com/articles/s41...
By any chance??? It is a cyanobacteria right?
Emergence of fractal geometries in the evolution of a metabolic enzyme - Nature
Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.
www.nature.com
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Reposted by Schuller Jan
georghochberg.bsky.social
georghochberg.bsky.social @georghochberg.bsky.social · 14d
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
www.biorxiv.org
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Schuller Jan @schullerjm.bsky.social · 15d
Oh wow, let's hope with our new discoveries we don't outdate it too fast ;)
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proloewe.bsky.social
ProLOEWE @proloewe.bsky.social · Sep 5
Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼‍🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung!
@synmikro.bsky.social @loewe-tree-m.bsky.social.
unimarburg.bsky.social
Universität Marburg @unimarburg.bsky.social · Sep 4
Dr. Jan Schuller erhält renommiertes Boehringer Ingelheim Stiftung (BIS) Stipendium. Im Fokus: Wie schädliche #Darmbakterien ohne #Sauerstoff Energie gewinnen – die Funktionsweise von #Clostridioides difficile uni-marburg.de/eOYjSV Foto: R K Wegst #Mikrobiologie #Kryo-Elektronenmikroskopie
Portray of Jan Schuller
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fjoreilly.bsky.social
Francis O'Reilly @fjoreilly.bsky.social · Aug 5
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
www.biorxiv.org
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Schuller Jan @schullerjm.bsky.social · Aug 1
What an amazing portrait for such an great violinist and scientist. Very well done. And very nice ending 😁 with the final in the music 🎶
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Reposted by Schuller Jan
kailalab.bsky.social
Ville Kaila @kailalab.bsky.social · Aug 1
Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q
He wants to reveal the secret behind the body's battery
YouTube video by Wallenbergstiftelserna
youtu.be
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olallalab.bsky.social
Olalla Vázquez @olallalab.bsky.social · Jul 29
#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
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Reposted by Schuller Jan
lisamaierlab.bsky.social
Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · Jul 16
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
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stcmicrobeblog.bsky.social
STCmicrobeblog @stcmicrobeblog.bsky.social · Jun 20
we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎)
#MicroSky
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Schuller Jan @schullerjm.bsky.social · Jun 11
This method is an absolute game changer 🔥 when applied to bioenergetic problems. You should have a read. Wait for it 😶‍🌫️ great things are coming!!!
Reposted by Schuller Jan
SchmitzStreitsLAB @schmitzstreitslab.bsky.social · Jun 4
Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de
Schuller Jan @schullerjm.bsky.social · Jun 4
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .

www.biorxiv.org/content/10.1101/2025.06.02.657420v1
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Schuller Jan @schullerjm.bsky.social · Jun 4
This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.
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Schuller Jan @schullerjm.bsky.social · Jun 4
The small protein MtrI blocks the Na+ binding subunit MtrCDE, bascially forming a plug for the channel. This could be important to prevent sodium leakage, when the complex gets damaged by oxygen.
Schuller Jan @schullerjm.bsky.social · Jun 4
The structure has also something for resolution fans! Such a nice coordinated sodium ion 😅
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Schuller Jan @schullerjm.bsky.social · Jun 4
Tristan could show this by pull-down experiments. Irrespective of the growth condition, the oxygen sensitive behaviour was present.
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Schuller Jan @schullerjm.bsky.social · Jun 4
This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.
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Schuller Jan @schullerjm.bsky.social · Jun 4
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .

www.biorxiv.org/content/10.1101/2025.06.02.657420v1
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Reposted by Schuller Jan
martinsteinegger.bsky.social
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Jun 3
Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...

Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
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Schuller Jan @schullerjm.bsky.social · Jun 2
Amazing paper, putting the spotlight on small proteins as modulators of the core bioenergetic machinery of methanogenesis.
Reposted by Schuller Jan
SchmitzStreitsLAB @schmitzstreitslab.bsky.social · Jun 2
Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD!
www.biorxiv.org/content/10.1...
Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Gö1 depending on the molecular hydrogen availability
Small open reading frame (small ORF)-encoded proteins, with less than 100 amino acids in length, have attracted increasing attention over the past decade after being largely overlooked due to limitati...
www.biorxiv.org
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xkcd.com
Randall Munroe @xkcd.com · May 30
Archaea

xkcd.com/3095/
Comic. PERSON: It’s weird how, despite being one of the main branches of the tree of life, no archaea species are known to cause disease in humans. PERSON WITH SHORT HAIR: Personally, I think it’s because those gross methane breathers are too weird and incompetent to figure out how to hurt us even if they wanted to. [from small point under microscope on desk]: *Hey!* [caption] Bad news: After overhearing a conversation in our lab, Archaea has finally started harming humans.
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Schuller Jan @schullerjm.bsky.social · May 31
This is so cool 😎 congratulations 🎉 amazing work.
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Schuller Jan @schullerjm.bsky.social · May 28
Does he believe in 0.143, 0.3 or 0.5 as the correct cutoff?
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