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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 23m

🤔Why settle for PyMOL when you can have ChimeraX?

My choice is clear: ChimeraX 💪

If you agree, share 🚀
If you’re a PyMOL fan… just try ChimeraX 😉

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Razvan Borza @rborza.bsky.social · 23m

🤔Why settle for PyMOL when you can have ChimeraX?

My choice is clear: ChimeraX 💪

If you agree, share 🚀
If you’re a PyMOL fan… just try ChimeraX 😉

1 2

Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · Jul 15

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀

💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.

❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁

Read it: www.jbc.org/article/S002...

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Reposted by Razvan Borza

Danielle Bianchi @daaninthelab.bsky.social · Jul 4

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

www.science.org

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 10d

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.

Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

Cell Reports @cp-cellreports.bsky.social · Mar 19

SRBD1, a highly conserved gene required for chromosome individualization

Raaijmakers et al. study S1 domain containing protein 1 (SRBD1), a previously uncharacterized essential protein. The loss of SRBD1 results in a complete failure in anaphase chromosome segregation due to defects established in prophase. The phenotype…

dlvr.it

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · Jul 8

📢 Ready for this? A new way to think about Gene Regulation!

🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬

💪Proud to be part of this work led by @daaninthelab.bsky.social

Read more: science.org/doi/10.1126/science.adv2861

3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation.
Made in Blender with Molecular Nodes.

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · Jul 9

🚀 My first Cryo-EM structures are OUT on the PDB!

🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌

🔁Thank you for sharing!❤️

Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...

⬇️ 2nd video

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Reposted by Razvan Borza

cryoEM papers @cryoempapers.bsky.social · Jul 4

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression pubmed.ncbi.nlm.nih.gov/40608935/ #cryoem

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Reposted by Razvan Borza

Maria Polychronidou @mpolychronidou.bsky.social · Jul 4

Zincore: an unconventional coregulator complex that interacts with the DNA binding domain of #zincfinger transcription factors & stabilizes them on their genomic consensus motifs ➡️ www.science.org/doi/10.1126/... #generegulation #transcriptionfactor #transcription

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

www.science.org

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Reposted by Razvan Borza

Waggoner Lab @labwaggoner.bsky.social · Jul 3

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression @science.org @thijnbrummel.bsky.social #Perrakis #Sebastian @daaninthelab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

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Razvan Borza @rborza.bsky.social · 9d

⚠️Don't forget! You have FREE alternatives!

🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov

📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.

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Razvan Borza @rborza.bsky.social · 10d

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.

Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

Cell Reports @cp-cellreports.bsky.social · Mar 19

SRBD1, a highly conserved gene required for chromosome individualization

Raaijmakers et al. study S1 domain containing protein 1 (SRBD1), a previously uncharacterized essential protein. The loss of SRBD1 results in a complete failure in anaphase chromosome segregation due to defects established in prophase. The phenotype…

dlvr.it

1 3

Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · Jan 23

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉

👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️

www.cell.com/trends/cell-...

A metallic arm holding a protein, simulating a GPI-anchored protein attached to the surface of a membrane.

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Reposted by Razvan Borza

Lidia Atencia Taboada @latencia.bsky.social · Jul 15

🚨 New strategy against colorectal cancer!

Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪

➡️Read more: www.nature.com/articles/s41...

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

www.nature.com

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Razvan Borza @rborza.bsky.social · Jul 17

Thank you! 😁

Razvan Borza @rborza.bsky.social · Jul 15

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀

💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.

❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁

Read it: www.jbc.org/article/S002...

1 5 16

Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · Apr 15

🚨New Article Out!!

📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒

🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance

♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...