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Reposted by Jenny Sachweh

Ben Larson @blarson.bsky.social · Aug 26

What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?

www.biorxiv.org/content/10.1...

Video by Vittorio Boscaro.

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Reposted by Jenny Sachweh

Sven Klumpe @svenklumpe.bsky.social · Aug 23

If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...

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Jenny Sachweh @jennysachweh.bsky.social · Aug 20

Thanks :)

Reposted by Jenny Sachweh

Tanner Fadero @tanner-fadero.bsky.social · Aug 19

How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!

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Jenny Sachweh @jennysachweh.bsky.social · Aug 19

Thanks Carolin!!

Jenny Sachweh @jennysachweh.bsky.social · Aug 19

Thanks Iskander!

Jenny Sachweh @jennysachweh.bsky.social · Aug 18

Thanks Tamas! Hope you’re doing well!

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Jenny Sachweh @jennysachweh.bsky.social · Aug 18

Special thanks from my side also to @sonjawelsch.bsky.social who keeps the electron microscopy facility @mpibp.bsky.social running!

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Jenny Sachweh @jennysachweh.bsky.social · Aug 18

Thanks to everyone involved: Mandy Börmel, Sven Klumpe (@svenklumpe.bsky.social), Anja Becker, Reiya Taniguchi, Marta Kubańska, Verena Pintschovius, Eva Kaindl, Jürgen Plitzko, Florian Wilfling (@wilflinglab.bsky.social),
Martin Beck (@becklab.bsky.social) and Bernhard Hampölz!

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Jenny Sachweh @jennysachweh.bsky.social · Aug 18

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

The small GTPase Ran defines nuclear pore complex asymmetry

Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

www.sciencedirect.com

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Reposted by Jenny Sachweh

EMBL @embl.org · Aug 8

At EMBL Grenoble, lead an independent research group using bold, original approaches to integrate complementary structural biology methods with emerging nano X-ray imaging technologies, bridging scales and modalities to unravel molecular mechanisms.

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

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Reposted by Jenny Sachweh

EMBL @embl.org · Aug 7

The Molecular Systems Biology Unit is looking for an independent research group leader in one of many different areas from integrative structural biology to synthetic biology, and from AI-driven approaches to engineering biological systems.

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

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Reposted by Jenny Sachweh

A. Reza Mehdipour @rezamehdipour.bsky.social · Aug 5

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...

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Jenny Sachweh @jennysachweh.bsky.social · Aug 3

The MPG is advertising directorships - powerful positions for which recruitment is usually started by them reaching out to potential candidates. Let’s hope this open call will get some great (but maybe overlooked) scientists on the candidate list and doesn’t accidentally select for oversized egos…

Max-Planck-Gesellschaft @maxplanck.de · Aug 1

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.

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Jenny Sachweh @jennysachweh.bsky.social · Jul 1

It's fun to let the angle t run though the whole range and M_xy = M_z = n_s is the only spot that doesn't change - same mag for all spatial frequencies!

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Reposted by Jenny Sachweh

Florian Wollweber @florianwollweber.bsky.social · Jun 27

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

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Reposted by Jenny Sachweh

Ewan Birney @ewanbirney.bsky.social · May 19

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

EMBL @embl.org · May 19

Interested in research infrastructures career?

The #ARISE2 Fellowship Programme might be right for you.
MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪

🗓️ Call opening: 30 June
www.embl.org/training/ari...

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Jenny Sachweh @jennysachweh.bsky.social · Jun 19

Beautiful cutting-edge in situ cryoET work (with very pretty figures) from the Grange lab!

Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!

cryoEM papers @cryoempapers.bsky.social · Jun 18

A generalizable and targeted molecular biopsy approach for in situ cryogenic electron tomography of vitreous brain tissue pubmed.ncbi.nlm.nih.gov/40527314/ #cryoem

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Reposted by Jenny Sachweh

Tanner Fadero @tanner-fadero.bsky.social · Jun 3

Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?

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Reposted by Jenny Sachweh

bioRxivpreprint @biorxivpreprint.bsky.social · May 28

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps https://www.biorxiv.org/content/10.1101/2025.05.27.656403v1

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Reposted by Jenny Sachweh

Carl T. Bergstrom @carlbergstrom.com · Apr 29

1. Can you figure out where I was standing when I took this picture?

ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.

A cityscape at twilight, from the middle of a street.

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Reposted by Jenny Sachweh

Josh Dickerson @joshdcryoem.bsky.social · Apr 23

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...

Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS

The physical limit in determining the atomic structure of biological molecules is radiation damage. In electron cryomicroscopy, there have been num...

www.pnas.org

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Reposted by Jenny Sachweh

Alfred Millett-Sikking @amsikking.bsky.social · Apr 14

Using the 'right tool for the job'. It's not fashionable, but a powerful and often underappreciated approach...

-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!

doi.org/10.1101/2022...

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Reposted by Jenny Sachweh

Sven Klumpe @svenklumpe.bsky.social · Apr 9

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

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Jenny Sachweh @jennysachweh.bsky.social · Apr 7

Cool idea form @svenklumpe.bsky.social to play with the FIB beam to achieve more efficient sample prep for in situ cryoET! Looking forward to seeing that in action!

bioRxivpreprint @biorxivpreprint.bsky.social · Apr 6

Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1

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