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Juan S. Bonifacino @juanbonifacino.bsky.social · 17h

Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects

Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling

academic.oup.com

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Juan S. Bonifacino @juanbonifacino.bsky.social · 11d

I agree. Thank you, @johnhawks, for your kind and thoughtful explanation. As someone outside the field of anthropology, it seems there's a rush to name new archaic human species—where skull anatomy is given more weight than genomic data, and even existing names are overlooked.

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Juan S. Bonifacino @juanbonifacino.bsky.social · 11d

Question from a neophyte: Given that the Harbin skull contains Denisovan DNA and protein signatures, why not refer to this whole group as Denisovans rather than using the more recent designation longi?

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Juan S. Bonifacino @juanbonifacino.bsky.social · 17d

Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!

‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science

Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.

journals.biologists.com

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Juan S. Bonifacino @juanbonifacino.bsky.social · 17d

Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social‬ for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn

Cell Chemical Biology @cp-cellchembiol.bsky.social · 19d

Meet the authors: Raffaella De Pace, Chad Williamson, and Juan Bonifacino http://dlvr.it/TN9cVw

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Reposted by Juan S. Bonifacino

Cell Chemical Biology @cp-cellchembiol.bsky.social · 19d

BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn

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Reposted by Juan S. Bonifacino

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 26

Excited to share our new review with @depaceraffa.bsky.social‬, @saikat2025.bsky.social‬, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 25

Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof

CHIP protects lysosomes from CLN4 mutant-induced membrane damage

Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...

rdcu.be

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 24

New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social ‬and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 21

👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

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Reposted by Juan S. Bonifacino

Dr. Tara L. Conley @taralconley.com · Jul 21

me, every work week battling with the cloud.

photo of hank hill during the episode when he was at the dmv talking to a representative with a completely unrelated capture that reads:

I do not want to save to one drive. I want to save to the documents folder… On my computer… That I own… In my house.

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Reposted by Juan S. Bonifacino

Razvan Borza @rborza.bsky.social · Nov 23

🚨 If you haven’t seen it yet…

📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.

Check it out at bioart.niaid.nih.gov

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Juan S. Bonifacino @juanbonifacino.bsky.social · Jun 29

With @manorlaboratory.bsky.social

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Juan S. Bonifacino @juanbonifacino.bsky.social · Jun 29

Nice to meet @manorlaboratory.bsky.social in Canada and learn of his work on label-free imaging!

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Juan S. Bonifacino @juanbonifacino.bsky.social · Jun 27

Ughh! Is it still accurate?

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Juan S. Bonifacino @juanbonifacino.bsky.social · Apr 29

Happy to have made a minor contribution to this exciting study by Tasha Morrison, John O’Shea, and colleagues highlighting the key role of glycosphingolipid metabolism in natural killer and CD8⁺ T cell biology. authors.elsevier.com/c/1l0F9_278y...

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Reposted by Juan S. Bonifacino

Anirban Banerjee @banirbn.bsky.social · Apr 8

Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks !
Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters.
bit.ly/42jWXYD.
/n

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Reposted by Juan S. Bonifacino

Carlos Guardia @charlyguardia.bsky.social · Apr 16

Job ad is here! Check it out :)

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Juan S. Bonifacino @juanbonifacino.bsky.social · Apr 13

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!

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Reposted by Juan S. Bonifacino

Traffic @traffic-journal.bsky.social · Mar 19

just published onlinelibrary.wiley.com/doi/full/10....

Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation

Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...

onlinelibrary.wiley.com

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Reposted by Juan S. Bonifacino

The Freeman Lab @spencerfreeman.bsky.social · Feb 27

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

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Juan S. Bonifacino @juanbonifacino.bsky.social · Jan 20

Welcome, Mark. Glad to have you here.

Juan S. Bonifacino @juanbonifacino.bsky.social · Jan 14

Congratulations, Anne @spanglab.bsky.social!

Juan S. Bonifacino @juanbonifacino.bsky.social · Jan 12

Were the names translated by ChatGPT? My favorite ones are Alison Doce Árboles and Conducto de Paul 🙃

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