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Reposted by Liam Faller

Ryan Flynn @raflynn5.bsky.social · 1d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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Liam Faller @liamfaller.bsky.social · 5d

☝️This one

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Reposted by Liam Faller

Glenn Masson @glennmasson.bsky.social · 6d

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Reposted by Liam Faller

International Society of Genetic Genealogy @isogg.bsky.social · 14d

“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...

Cycling linked with lower dementia risk, study finds | CNN

Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.

www.cnn.com

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Liam Faller @liamfaller.bsky.social · 26d

Thanks Denis!

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Liam Faller @liamfaller.bsky.social · Sep 8

Couldn't make it today, but I'll see you there tomorrow!

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Liam Faller @liamfaller.bsky.social · Sep 1

Kudos to Anna Dopler (not on the socials) who led both this study, and the P-stalk one! Thanks to @nar-cancer-editor.bsky.social for publishing it too!

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Liam Faller @liamfaller.bsky.social · Sep 1

I loved this project because we were looking at 2 members of the ribosome, that had essentially the same effect (reduced antigen presentation), but through completely different mechanisms. Just shows how much there is still to learn about the ribosome!

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Liam Faller @liamfaller.bsky.social · Sep 1

Turns out they aren't! The P-stalk controls the translation of HLA (and other cytokine-regulated genes), while uL14 regulates the generation and processing of peptides, resulting in the production of more unstable peptides, and reduced presentation as a result.

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Liam Faller @liamfaller.bsky.social · Sep 1

A few years ago the Restifo lab showed that another ribosomal protein (uL14) was also essential for antigen processing and presentation. We wondered whether these two proteins from the same complex were doing the same thing.

www.nature.com/articles/nat...

Identification of essential genes for cancer immunotherapy - Nature

The authors describe a two-cell-type CRISPR screen to identify tumour-intrinsic genes that regulate the sensitivity of cancer cells to effector T cell function.

www.nature.com

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Liam Faller @liamfaller.bsky.social · Sep 1

This is a follow on from our Cell paper last year, where we showed that the ribosomal P-stalk was crucial for cellular responses to cytokines.

www.cell.com/cell/fulltex...

P-stalk ribosomes act as master regulators of cytokine-mediated processes

Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the translation of mRNAs involved in cytokine responses.

www.cell.com

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Liam Faller @liamfaller.bsky.social · Sep 1

Here's the latest from the lab! In it we dive into the role of ribosomal proteins in antigen processing and presentation!

academic.oup.com/narcancer/ar...

Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance

Abstract. The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates

academic.oup.com

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Liam Faller @liamfaller.bsky.social · Aug 28

Very cool stuff on the co-translational folding of dimers by Sander Tans and his team @amolf-nl.bsky.social:

www.nature.com/articles/s41...

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications

Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...

www.nature.com

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Reposted by Liam Faller

Margot Finn @eicathomefinn.bsky.social · Aug 24

'Cancer Research UK told The Observer that several pieces of research had been affected by...immigration costs, which have risen by 126% since 2019 and are up to 17 times higher than the average of comparable countries including France, Australia, the US and South Korea.' Not only cancer research.

Cancer research ‘set back years’ as visa fees drive scien...

With vital studies being shelved and foreign experts turning down jobs, leading charity urges ministers to act

observer.co.uk

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Reposted by Liam Faller

Liana Lareau @lianafaye.bsky.social · Aug 7

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Protein language models reveal evolutionary constraints on synonymous codon choice

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

www.biorxiv.org

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Reposted by Liam Faller

Martin Ott lab @mitolab.bsky.social · Jul 18

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis

Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

academic.oup.com

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Reposted by Liam Faller

Sergey Melnikov @sergeymelnikov.bsky.social · Jun 19

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

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Reposted by Liam Faller

Health Nerd @gidmk.bsky.social · Jun 2

I'm reading the report behind these headlines about glyphosate and it may be the most scientifically illiterate thing I've come across (although it's a close thing with the recent MAHA report). 1/n

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Reposted by Liam Faller

Sendoel Lab @sendoellab.bsky.social · May 26

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x

www.biorxiv.org/content/10.1...

The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control

The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...

www.biorxiv.org

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Reposted by Liam Faller

Julie @rna-julie.bsky.social · May 14

Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...

Translational activity of 80S monosomes varies dramatically across different tissues

Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational

academic.oup.com

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Reposted by Liam Faller

Rafeeque Mavoor @rafeeque.com · May 13

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

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Liam Faller @liamfaller.bsky.social · May 8

New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data.

academic.oup.com/nargab/artic...

Detecting ribosome collisions with differential rRNA fragment analysis in ribosome profiling data

Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp

academic.oup.com

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Reposted by Liam Faller

Mehdi Jafarnejad @rnanomad.bsky.social · May 6

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates

www.sciencedirect.com/science/arti...

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that pa…

www.sciencedirect.com

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Liam Faller @liamfaller.bsky.social · May 6

Very interesting work from Samie Jaffrey's lab: m6A promotes ribosome collisions, with big effects on RNA stability. #RNASky

www.cell.com/cell/fulltex...

m6A alters ribosome dynamics to initiate mRNA degradation

m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor linking translation dynamics to m6...

www.cell.com

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Liam Faller @liamfaller.bsky.social · Apr 29

Fantastic stuff by @yardenasamuels.bsky.social lab. The translational regulation of antigen presentation just gets more and more interesting! #RNAbiology #RNASky

www.sciencedirect.com/science/arti...

Translation dysregulation in cancer as a source for targetable antigens

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized…

www.sciencedirect.com

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