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Reposted by Martin Ott lab

MPI for Biology of Ageing @mpiage.bsky.social · 14d

📢 Publication Alert: We're excited to share a new study from the Langer Lab published in @nature.com! It uncovers how an excess of RNA building blocks can destabilize mitochondrial DNA, which plays a role in age-related inflammation.

www.nature.com/articles/s41...

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

www.nature.com

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Reposted by Martin Ott lab

Stirling Churchman @stirlingchurchman.bsky.social · 29d

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

HuD controls widespread RNA stability to drive neuronal activity-dependent responses

Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...

www.biorxiv.org

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Martin Ott lab @mitolab.bsky.social · Sep 2

Our new study in collaboration with the labs of Toni Barrientos (Miami) and Henning Urlaub (Göttingen) on late stages of mitoribosome assembly in yeast. Cryo-EM by our former PhD student Sorbhi and Julian from scilifelab. Funding by
@kawresearch.bsky.social
authors.elsevier.com/c/1liOmc5IDu...

authors.elsevier.com

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Martin Ott lab @mitolab.bsky.social · Jul 18

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis

Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati

academic.oup.com

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Martin Ott lab @mitolab.bsky.social · Jun 18

We just returned from a great retreat with the @osman-lab.bsky.social in the Austrian alps. Intensive scientific discussions on mitochondrial gene expression, fun people, delicious food and great scenery, thank you so much everyone!

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Reposted by Martin Ott lab

Mito@GU @mito-at-gu.bsky.social · Apr 9

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

www.nature.com

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Reposted by Martin Ott lab

Florent Waltz @florentwaltz.bsky.social · Mar 20

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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Reposted by Martin Ott lab

Ben Engel @cellarchlab.com · Mar 20

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Science Magazine @science.org · Mar 20

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

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Martin Ott lab @mitolab.bsky.social · Mar 3

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658

Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

www.nature.com

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Martin Ott lab @mitolab.bsky.social · Feb 4

We have an open Postdoc position!
Join our lab in Gothenburg at the beautiful west coast of Sweden to work on an exciting project:
www.nature.com/naturecareer...

Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658

Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...

www.nature.com

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Martin Ott lab @mitolab.bsky.social · Jan 30

A new fundamental paper from Manu Hegde´s group: Mechanism of chaperone recruitment and retention on mitochondrial precursors
www.molbiolcell.org/doi/10.1091/...

Mechanism of chaperone recruitment and retention on mitochondrial precursors | Molecular Biology of the Cell

Nearly all mitochondrial proteins are imported into mitochondria from the cytosol. How nascent mitochondrial precursors acquire and sustain import-competence in the cytosol under normal and stress con...

www.molbiolcell.org

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