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Vicki Metzis @vmetzis.bsky.social · 15d

Many thanks James - pleased to share this publication and to see it highlighted in the current issue @cp-devcell.bsky.social

James Briscoe @jamesbriscoe.bsky.social · 16d

Great to see this from @vmetzis.bsky.social & co published

Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch

www.cell.com/developmenta...

A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation

Amblard et al. dissect the function of cis-regulatory elements regulating transient Cdx2 expression during mouse caudal body formation. They highlight the requirement of an attenuator, a transiently r...

www.cell.com

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Vicki Metzis @vmetzis.bsky.social · Aug 1

Application deadline for up to 5 @mrc-lms.bsky.social postdoc positions in developmental epigenetics closes soon - don’t miss out! Positions across both experimental and computational projects. Come and join our fantastic team science community!

Vicki Metzis @vmetzis.bsky.social · Jul 14

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

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Vicki Metzis @vmetzis.bsky.social · Jul 14

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

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Reposted by Vicki Metzis

Christina Ernst @christinaernst.bsky.social · Jul 11

My team @ebi.embl.org is open to hosting #ARISE2 fellows!

We‘re especially interested in projects that improve access to single-cell & spatial transcriptomics data (e.g. browsers, standards), or enhance AI-readiness.

Happy to chat if you are applying!

www.embl.org/training/ari...

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Vicki Metzis @vmetzis.bsky.social · Jul 12

Congratulations to my colleague Will Scott @mrc-lms.bsky.social on his latest work resolving the molecular changes in fat tissue that emerge following weight loss www.nature.com/articles/s41...

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Reposted by Vicki Metzis

Juliane Glaser @julianeg.bsky.social · Jul 9

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

www.nature.com

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Vicki Metzis @vmetzis.bsky.social · Jul 9

Very nice Juliane, great to see it out!

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Reposted by Vicki Metzis

MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · Jul 4

Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research?

Apply now for our two-year Science Technology Graduate Programme!

You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.

Science Technology Graduate Programme - MRC Laboratory of Medical Sciences

Bioinformatics Facility - Dr George Young and Electron Microscopy Facility - Dr Ricardo Aramayo

lms.mrc.ac.uk

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Reposted by Vicki Metzis

Helena Cocheme @cochemelab.bsky.social · Jun 27

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

doi.org

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Reposted by Vicki Metzis

Evgeny Kvon @evgenykvon.bsky.social · Jul 2

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Range extender mediates long-distance enhancer activity - Nature

The REX element is associated with long-range enhancer–promoter interactions.

www.nature.com

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Vicki Metzis @vmetzis.bsky.social · Jun 29

Thanks a lot Joaquina!

Vicki Metzis @vmetzis.bsky.social · Jun 29

Many thanks Silvia!

Vicki Metzis @vmetzis.bsky.social · Jun 29

Thanks a lot Juliane!

Vicki Metzis @vmetzis.bsky.social · Jun 29

Thanks a lot Kristina!

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Vicki Metzis @vmetzis.bsky.social · Jun 28

Many thanks to @drsingleman.bsky.social for interviewing us about our latest work @imperialmed.bsky.social @mrc-lms.bsky.social - here’s her news story in GEN

www.genengnews.com/topics/genom...

Genetic “Dimmer Switch” Offers Precise Gene Expression Control

The duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.”

www.genengnews.com

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Vicki Metzis @vmetzis.bsky.social · Jun 28

Thanks very much!

Reposted by Vicki Metzis

Damir Baranasic @da-bar.bsky.social · Jun 28

I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell!

Vicki Metzis @vmetzis.bsky.social · Jun 27

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social