Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social

www.biorxiv.org/content/10.1...

🚨 Our new preprint!
In collaboration with @saramaciasrna.bsky.social and @heick.bsky.social labs
🧬 Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 and its implications in 22q11.2 deletion syndrome.
#22q11 #TEsky #RNAsky

In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?

In collaboration with @herassr.bsky.social and @heick.bsky.social labs

www.biorxiv.org/content/10.1...

Exciting work! Plasmids are available at Addgene: www.addgene.org/browse/artic...

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.

journals.biologists.com/dev/article/...

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...

Epigenetics Update - OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide go.nature.com/4laK9MG

#Epigenetics #DNAdemethylation #mESCs
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Gain deeper insights into gene regulation; epigenometech.com

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.

As well as ambitious proposals for R&I in the next EU budget.

We will also offer the best and brightest the right incentives to come to Europe ↓

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Esta pérdida de un alelo de DGCR8 ocurre en el síndrome 22q11 y señala que no siempre los modelos de ratón reflejan la complejidad en humana.

Gracias a los coautores y las IPs @herassr.bsky.social y @saramaciasrna.bsky.social, así como a @uji.es

Artículo aquí ➡️ academic.oup.com/nar/article/...

🔴 NUEVO ARTÍCULO DE NUESTRO GRUPO en @narjournal.bsky.social!!! 🧬 #TEsky

La pérdida de un alelo del gen DGCR8 en células madre embrionarias humanas afecta a su pluripotencia interfiriendo en una red de elementos transponibles y microARNs que es específica de primates. (1/2)

Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...

Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽‍♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC
Thanks to all the coauthors and funders

academic.oup.com/nar/article/...

No os perdáis este artículo sobre la relación entre los microARN y el cáncer. Por @herassr.bsky.social y nuestro socio Pablo Tristán