The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX...

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...

Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...

The study, published in Nature Communications, provides the most detailed picture yet of how cells from the tick species Rhipicephalus microplus respond to infection with severe fever with thrombocytopenia syndrome virus (SFTSV).SFTSV can cause high fever, internal bleeding and death in humans and currently has no licensed treatment or vaccine.

Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...