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Fletcher Lab @fletcherlab.bsky.social · 9h

🎉 Fletcher lab PhD student Emma Davies reflecting on her prize winning talk - we’re super proud of you Emma - many congrats! 🎉

@cvrinfo.bsky.social @uofgsii.bsky.social @uofgmvls.bsky.social

Microbiology Society @microbiologysociety.org · 1d

Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!

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Aaron Whiteley @aaronwhiteley.bsky.social · 13h

Our work on the Panoptes antiphage system is published! Here we find that Panoptes "watches" the cytosol for phage immune evasion proteins–captured in this illustration by Clair Huffine of Insight Illustrations. A beautiful example of the effector triggered immunity paradigm.

Illustration depicting a bacterium under assault by phage. The bacterium “sees” phage immune evasion proteins and protects itself using a newly described antiphage system called Panoptes, named for the many-eyed mythical giant Argus Panoptes. Credit: Clair Huffine Insight Illustrations LLC

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Ulad Litvin @ulad-litvin.bsky.social · 12d

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵

📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology

imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

doi.org

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Lorenz Lab @sonjalorenzlab.bsky.social · 14d

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity

Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

www.sciencedirect.com

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Fletcher Lab @fletcherlab.bsky.social · 19d

Aye

Fletcher Lab @fletcherlab.bsky.social · 19d

Liam please can we come to you for advice when naming our manuscripts?

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Dr Liam Brierley @liambrierley.bsky.social · 20d

🚨📝 New work via @thepandemicinst.bsky.social now preprinted!

We took ~19000 sequences of avian influenza virus and trained machine learning models on >40000 genomic/proteomic features - the resulting ensemble can predict zoonotic potential with AUC=0.95. More below!

www.biorxiv.org/content/10.1...

An AI for an AI: identifying zoonotic potential of avian influenza viruses via genomic machine learning

Avian influenza remains a serious risk to human health via zoonotic transmission, as well as a feasible pandemic threat. Although limited zoonotic cases have resulted from the current epizootic outbre...

www.biorxiv.org

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Rune Busk Damgaard @rbdamgaard.bsky.social · 22d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

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Charlotte Lewis @cb99-lewis.bsky.social · 25d

Had a brilliant time at the 9th International Calicivirus Conference in Banff (www.calicivirusconference.com) - phenomenal science in a phenomenal setting! It was great to present my PhD work so far (thanks @dbhella.bsky.social for the pic). Here's to many more!

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Fletcher Lab @fletcherlab.bsky.social · Sep 8

Pre-print: our description of RZ affiliate ZNFX1 is now online.

On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution.

Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social

www.biorxiv.org/content/10.1...

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX...

www.biorxiv.org

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Lena Steckelberg @lenasteckelberg.bsky.social · Sep 4

So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology

Jeanine Gezelle @jgezelle.bsky.social · Sep 2

Our study from the Steckelberg lab is out now in @narjournal.bsky.social !! We dove into a new nuclease-blocking viral #RNA structure important for viral infection, which provided evidence of similar structure-based strategies across diverse viral families. academic.oup.com/nar/article/...

A conserved viral RNA fold enables nuclease resistance across kingdoms of life

Abstract. Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence

academic.oup.com

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 28

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

www.cell.com

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Fletcher Lab @fletcherlab.bsky.social · Aug 25

Opening for a biochemist to help us in the characterisation of novel ubiquitin-based antivirals. Diverse backgrounds welcomed; a keen sense of adventure is a must 😁

Details and criteria are below; please get in touch with any questions.

www.jobs.gla.ac.uk/job/research...

Research Assistant/Associate

Research Assistant/Associate COLLEGE OF MVLSSchool of Infection & ImmunityResearch and TeachingGRADE 6/7 Job PurposeThe post holder will join the School of Infection & Immunity, MRC-Univers...

www.jobs.gla.ac.uk

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Brennan Lab CVR @brennanlab.bsky.social · Aug 13

Post 5/5 🧵
IMPACT: This transforms tick-borne disease research:
🎯 New drug targets
🎯 Understanding vector competence
🎯 Virus-tick evolution
Testing if mechanisms work across other tick viruses next.

👨‍🔬 collaborative project with @alf-castello.bsky.social and @alainkohlvirology.bsky.social

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ahellab.bsky.social @ahellab.bsky.social · Jul 10

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

www.nature.com

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Peter Mabbitt @petermabbitt.bsky.social · Jul 8

How predictable are the evolutionary pathways leading to insecticide resistance? Why do some species gain resistance while others do not? We explore these questions in our latest preprint. A huge effort from Rebecca Frkic, Alex Giang, Colin Jackson and the team.

www.biorxiv.org/content/10.1...

Nine rounds of directed evolution resulted in LcαE7 variants with increased rates of OP-hydrolysis. Three LcαE7 genes (wild-type, G137D and R9) were introduced into the genome of Drosophila. Fluorometric substrate DEUP, and insecticides Diazinon and Paraoxon are shown with the scissile bond indicated in red.

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Ylva Ivarsson @ivarssonlab.bsky.social · Jun 30

We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...

PhD student in Biochemistry - Uppsala University

PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

www.uu.se

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Clausen Lab @clausenlab.bsky.social · Jun 24

postdoc opening in vienna: study lipid droplets (LDs) with integrative structural biology, uncover how LD proteins shuttle between cytosol & nucleus to regulate lipid metabolism, organelle architecture and immune response. #VIP3 #lipidtime #cryoEM #coffee training.vbc.ac.at/post-docs/vi...

VIP³ Post Doc Program (2025 - 2030)

VIP3 is a postdoctoral fellowship program at the Vienna BioCenter offering three – year fellowships that are open to candidates with backgrounds in life sciences, chemistry, physics, medicine, enginee...

training.vbc.ac.at

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Alfredo Castello @alf-castello.bsky.social · Jun 3

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

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Marine Petit @virotick.bsky.social · May 23

OMG! I can finally share my joy to see my SFTSV work published in @natcomms.nature.com! This adventure started by the award of my MSCA grant and my move to the Kohl and @brennanlab.bsky.social at @cvrinfo.bsky.social. Let's chat about how we discovered novel tick anti-viral effectors!

Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications

Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...

www.nature.com

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Juraj Ahel @juraj-ahel.bsky.social · May 22

Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...!

Many thanks to all the groups involved:
@clausenlab.bsky.social
@e3chembio.bsky.social
@fletcherlab.bsky.social

Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:

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Jonathan Pruneda @jnpruneda.bsky.social · May 17

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

www.biorxiv.org

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Zha Lab @zhalab.bsky.social · May 16

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature

Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

www.nature.com

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Fletcher Lab @fletcherlab.bsky.social · May 14

Thanks to all the many who contributed along the way and the very supportive editorial team @natcomms.nature.com

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