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Reposted by Ylva Ivarsson

Shahar Sukenik @shaharsu.bsky.social · 5d

Can't wait to see you all there!!

idpgrc.bsky.social @idpgrc.bsky.social · 6d

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...

2026 Intrinsically Disordered Proteins Conference GRC

The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

grc.org

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Ylva Ivarsson @ivarssonlab.bsky.social · 6d

Never thought I would say this, but I need a Dane.. novonordiskfonden.dk/grant/postdo...

Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden

novonordiskfonden.dk

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Ylva Ivarsson @ivarssonlab.bsky.social · 16d

Fabulous work by Aimiliani Konstantinou, together with three other #UBIMOTIF members Alicia Córdova-Pérez, Julia K. Varga & Maximilian Vieler. #CYLD, #USP7, #USP11, #USP20, #USP22, #USP33

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Ylva Ivarsson @ivarssonlab.bsky.social · 16d

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases

The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

www.biorxiv.org

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Reposted by Ylva Ivarsson

Amelie Stein @amelierocks.bsky.social · 20d

Cool project with the Pless lab on disease-associated variants in a membrane protein, NALCN, that needs to be in complex to function. Most of our computational work was done by PhD student Aleks Panfilova.

PlessLab @plesslab.bsky.social · 21d

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...

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Reposted by Ylva Ivarsson

PMC Protein Modules Community @pmc-modularity.bsky.social · 23d

Tune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

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Reposted by Ylva Ivarsson

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Sep 8

To protein designers (and others)

The Dept of Chemistry, Lund University & the Wallenberg Initiative for Materials Science for Sustainability is looking for an Assoc Senior Lecturer/Assist Professor in Biomolecular materials with a focus on de novo design and synthesis

lu.varbi.com/en/what:job/...

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Reposted by Ylva Ivarsson

PMC Protein Modules Community @pmc-modularity.bsky.social · Aug 15

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

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Reposted by Ylva Ivarsson

Jorge Bravo Abad @bravo-abad.bsky.social · Aug 16

Leo Tianlai Chen and coauthors present PepMLM, an ESM-2–based protein language model that designs target-specific peptide binders from sequence alone, enabling binding and degradation of disease and viral proteins. www.nature.com/articles/s41...

Target sequence-conditioned design of peptide binders using masked language modeling - Nature Biotechnology

PepMLM designs peptide binders against diverse targets using masked language modeling.

www.nature.com

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Reposted by Ylva Ivarsson

EMBL @embl.org · Aug 7

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇

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Reposted by Ylva Ivarsson

Ylva Ivarsson @ivarssonlab.bsky.social · Jun 30

We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...

PhD student in Biochemistry - Uppsala University

PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

www.uu.se

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bioRxiv SysBio @biorxiv-sysbio.bsky.social · Jul 5

Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 https://www.biorxiv.org/content/10.1101/2025.07.01.662654v1

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Reposted by Ylva Ivarsson

Neel Shah @nshahlab.bsky.social · Jul 1

And of course, we could not have done this without NIH funding that has been critical for supporting my students’ training and my career, and for giving us the resources to shed light on some aspects of the molecular basis of human diseases.

Neel Shah @nshahlab.bsky.social · Jul 1

Excited to see this paper out in its final form, and huge congrats to first author Ziyuan (Jason) Jiang just a week before his thesis defense. This work has become an invaluable resource in our lab for SHP2 projects, and we hope it resonates with the whole field.

www.nature.com/articles/s41...

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Reposted by Ylva Ivarsson

Katja Luck @katjaluck.bsky.social · Jul 1

Variant characterization in the intrinsically disordered human proteome - here is how we did it using short linear motif prediction, AlphaFold, and experimentation. Check out our preprint: www.biorxiv.org/cgi/content/...

Variant characterization in the intrinsically disordered human proteome

Variant effect prediction remains a key challenge to resolve in precision medicine. Sophisticated computational models that exploit sequence conservation and structure are increasingly successful in t...

www.biorxiv.org

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Ylva Ivarsson @ivarssonlab.bsky.social · Jun 30

.. more information about the IDPro network here: idpro.elte.hu

IDPro

idpro.elte.hu

Reposted by Ylva Ivarsson

Evangelia Petsalaki @epetsalaki.bsky.social · Jun 30

Do you have experience in mechanistic modelling of biological systems and want to do a postdoc with an interdisciplinary team on developing Digital Twins for rare disease? We have the job for you! Check it out below - deadline July 13th, online interviews 24th July.

Evangelia Petsalaki @epetsalaki.bsky.social · Jun 24

Your weekly reminder that there is a really fun post @ebi.embl.org in our group in collaboration with Sheriff Rahuman (@biomodels) and Ellie McDonagh (@opentargets) to create Digital Twins for rare disease using multiomics, executable modelling and AI. Join our interdisciplinary team! Deadline 13/07

Evangelia Petsalaki @epetsalaki.bsky.social · Jun 13

Exciting opportunity at the forefront of network biology, multiomics, AI and DT. Deadline 13th July! embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

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Ylva Ivarsson @ivarssonlab.bsky.social · Jun 30

We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...

PhD student in Biochemistry - Uppsala University

PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

www.uu.se

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Sten Linnarsson @sten.linnarsson.org · Jun 25

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Karolinska Institutet @ki.se · Jun 25

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...

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Peter Mace @petermace.bsky.social · Jun 20

It's June 20 in New Zealand, which means it's the last day to have your abstract considered for oral presentations at the IUBMB Focussed Meeting on kinases and pseudokinases!

Peter Mace @petermace.bsky.social · Jun 17

Check out the view today from the venue—scoping for the IUBMB Focussed meeting on (pseudo)kinases! Abstracts and early bird registrations closes this week!

www.ivvy.com.au/event/IUBMB25/

@pseudokinase.bsky.social @iubmb.bsky.social

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · Jun 18

Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions https://www.biorxiv.org/content/10.1101/2025.06.13.659429v1

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Kalli Kappel @kallikappel.bsky.social · Jun 17

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!

rdcu.be/eq975

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

rdcu.be

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jun 12

“The search is on for 25 researchers from around the world in Lund University’s largest ever international recruitment drive. The main focus will be on AI research and other areas in which the University has a strategic focus.”

www.lunduniversity.lu.se/article/lund...

Lund University launches largest-ever global recruitment drive for researchers

Lund University. Lund University’s body of researchers is getting reinforcements. If all goes according to plan, no fewer than 25 new researchers from all over the world will arrive in Lund this autum...

www.lunduniversity.lu.se

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Pedro Beltrao @pedrobeltrao.bsky.social · Jun 9

New lab preprint - Delora Baptista tested AlphaFold 2 and 3 for the prediction of structures of host-pathogen interactions and then applied these to study convergence of binding and molecular mimicry in host-pathogen vs. host-host interactions.
www.biorxiv.org/content/10.1...

AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry

Pathogens exploit host cellular machinery through protein-protein interactions (PPIs), often using molecular mimicry to hijack host cellular processes. While there have been thousands of host-pathogen...

www.biorxiv.org

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Ylva Ivarsson @ivarssonlab.bsky.social · Jun 7

"Journal name : POSITIF JOURNAL - we can publish papers of all subjects." Very positive indeed.

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PMC Protein Modules Community @pmc-modularity.bsky.social · Jun 6

TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

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