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PlessLab

@plesslab.bsky.social

1.3K followers 280 following 42 posts

Ion channels, biophysics, chemical biology, protein engineering and molecular neuroscience; Professor at University of Copenhagen; www.theplesslab.com

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Reposted by PlessLab

Magnus Bauer @kinasekid.bsky.social · 8d

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

PlessLab @plesslab.bsky.social · 10d

When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!

PlessLab @plesslab.bsky.social · 20d

Thanks so much for contributing to this!!

PlessLab @plesslab.bsky.social · 21d

A huge thank you to everyone involved and of course @lundbeckfonden.bsky.social, @carlsbergfondet.dk and DFF for funding.

PlessLab @plesslab.bsky.social · 21d

Collaborator @amelierocks.bsky.social complemented this with predictions of protein stability and conservation scores. In combination with functional work this establishes a framework for classifying suspected disease variants, which we hope will aid assessment of NALCN variant pathogenicity

PlessLab @plesslab.bsky.social · 21d

@chowhanchua.bsky.social implemented use of a combination of multiple parameters derived from two-electrode voltage-clamp electrophysiology recordings. These allow us to classify LoF and GoF phenotypes and to provide mechanistic insight into the molecular mechanism underlying specific variants.

PlessLab @plesslab.bsky.social · 21d

De novo and inherited NALCN variants can lead to severe developmental syndromes. Although variants of uncertain significance or presumed pathogenic variants have been studied in heterologous systems before, there is no generally accepted framework on how to assess or predict variant pathogenicity.

PlessLab @plesslab.bsky.social · 21d

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...

Reposted by PlessLab

Lorne Proteins @lorneproteins.bsky.social · 23d

Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions!

🔗 Register here: www.lorneproteins.org/register

Reposted by PlessLab

Angelika Lampert @lampertlab.bsky.social · Sep 6

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

Oksana Iamshanova @iamshanovao.bsky.social · Sep 1

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.

🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.

💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd

💻 More info:
lnkd.in/eJw9pfMz

Reposted by PlessLab

Journal of General Physiology @jgp.org · Sep 5

Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/...

#Evolution #IonChannels

Reposted by PlessLab

Oksana Iamshanova @iamshanovao.bsky.social · Sep 1

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.

🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.

💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd

💻 More info:
lnkd.in/eJw9pfMz

PlessLab @plesslab.bsky.social · Aug 22

Great to see so much exciting ion channel/membrane protein work going on in the far North!

PlessLab @plesslab.bsky.social · Aug 22

Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills

Reposted by PlessLab

Lorne Proteins @lorneproteins.bsky.social · Aug 21

🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞

February 8–12, 2026

Register here: www.lorneproteins.org

PlessLab @plesslab.bsky.social · Aug 20

Congratulations to you and the team - amazing work!

Reposted by PlessLab

Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · Aug 15

Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...

Prevalence of errors in lab-made plasmids across the globe

Abstract. Plasmids are indispensable in life sciences research and therapeutics development. Currently, most labs custom-build their plasmids. As yet, no s

academic.oup.com

Reposted by PlessLab

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Aug 6

Villum Sabbatical grant:

For US-based researchers wishing to visit a Danish university for up to 12 months

Deadline Aug. 15th 2025

villumfonden.dk/en/group/cha...

Villum Foundation wishes to encourage the exchange of scientific ideas between the US and Denmark. Villum Sabbatical supports research stays of up to one year at a Danish university. Researchers at the associate professor or professor level based at a US university may receive up to 1 MDKK to cover their salary (in part or in full), salary of accompanying group members (postdocs and PhD students), travel and research costs associated with the stay. Applications are only accepted from the head of the department at the Danish host institution.

If a visiting researcher subsequently decides to relocate to Denmark, they are encouraged to apply for one of Villum Foundations’s investigator grants (Young Investigator, Ascending Investigator, Investigator)

Reposted by PlessLab

henrietteautzen.bsky.social @henrietteautzen.bsky.social · Aug 3

🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen

Come work with a great team and exciting projects in a collaborative environment!

🔗 Links to the ads in comments

#CryoEM #AcademicJobs

Reposted by PlessLab

Journal of General Physiology @jgp.org · Jul 16

@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...

Reposted by PlessLab

Christian A. Olsen @christianaolsen.bsky.social · Jul 8

We are hiring at the Department of Drug Design and Pharmacology.
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.

employment.ku.dk/faculty/?sho...

164291 Associate Professor or Professor

employment.ku.dk

PlessLab @plesslab.bsky.social · Jul 6

Thank you, Yamuna

PlessLab @plesslab.bsky.social · Jul 6

We are very grateful to the many contributors, incl our fantastic collaborators in the Lundby, Wellendorph & Schramek groups. Special thanks to Nadine Ritter for her copious patch-clamp contributions.
This collaborative effort funded from the @lundbeckfonden.bsky.social and DFF.

PlessLab @plesslab.bsky.social · Jul 6

“It’s the company that matters!”

This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1

All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social

www.biorxiv.org/cgi/content/...

Reposted by PlessLab

Sten Linnarsson @sten.linnarsson.org · Jun 25

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Karolinska Institutet @ki.se · Jun 25

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...