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Reposted by Journal of General Physiology

Society of General Physiologists @sgpweb.bsky.social · 1d

A reminder to join us for the SGP Cranefield Award Talks, taking place tomorrow, 8 October, from 12:00 pm to 1:30 pm Eastern. Register (no fee) at bit.ly/sgp2025crane....

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Reposted by Journal of General Physiology

Colin Nichols Lab @colinnicholslab.bsky.social · 1d

Check out our new publication "PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating" 🧪
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Journal of General Physiology @jgp.org · 5d

Eva-Maria Zangerl-Plessl, Sun-Joo Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social

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Reposted by Journal of General Physiology

Colin Nichols Lab @colinnicholslab.bsky.social · 1d

Check out our new publication "Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice" 🧪 @rosca26.bsky.social
A 🧵 1/n

Journal of General Physiology @jgp.org · 1d

Scala et al. @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles showed enhanced fatiguing that was reversed by the KATP channel inhibitor glibenclamide.

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

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Journal of General Physiology @jgp.org · 1d

Scala et al. @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles showed enhanced fatiguing that was reversed by the KATP channel inhibitor glibenclamide.

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

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Journal of General Physiology @jgp.org · 1d

Scala et al. @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles showed enhanced fatiguing that was reversed by the KATP inhibitor glibenclamide.

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

Journal of General Physiology @jgp.org · 1d

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, and Rubem Carlos Araújo Guedes reveal that dopaminergic signaling influences cortical excitability and cortical spreading depression dynamics, offering new mechanistic insights into dopamine’s cortical role.

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Topical application of D2 receptor ligands modulates CSD propagation in a ligand- and time-dependent manner. Electrophysiological and immunohistochemical a

rupress.org

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Reposted by Journal of General Physiology

Society of General Physiologists @sgpweb.bsky.social · 5d

Want to learn more about the amazing work of our ⭐️2025 SGP #CranefieldAwards⭐️recipients @huanghe-lab.bsky.social and Man Si, published in @jgp.org? 👏Join us online on🗓️ Wednesday, 8 October, at ⏲️ 12:00 pm Eastern! Register🆓👉http://bit.ly/sgp2025cranefield.

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Journal of General Physiology @jgp.org · 5d

Eva-Maria Zangerl-Plessl, Sun-Joo Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social

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Journal of General Physiology @jgp.org · 14d

We’re thrilled to welcome Teresa Giraldez (@giraldezt.bsky.social) from @itb-ull.bsky.social @ull.es to the JGP editorial team! Prof. Giraldez brings a wealth of knowledge on ion channels, signaling nanodomains, and neurological diseases 🙌 Read the full announcement: rupress.org/jgp/pages/gi...

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Journal of General Physiology @jgp.org · 20d

For #PeerReviewWeek's AI focus, we want to take a moment to thank the people behind the peer review process. Our position is that rigorous peer review demands direct accountability that only human reviewers can provide. Thank you for all that you do!

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Journal of General Physiology @jgp.org · 20d

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

Journal of General Physiology @jgp.org · 26d

NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...

#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels

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Journal of General Physiology @jgp.org · 27d

Investigating the Role of the I–II Linker in Nav1.5 Channel Function. New study from Emily Wagner, Jonathan Silva and colleagues @washuengineers.bsky.social: rupress.org/jgp/article/...

#Biophysics #Pathophysiology #IonChannels

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Journal of General Physiology @jgp.org · Sep 8

ICYMI: JGP 2025 Highlights Collection provides new insights into the mechanism of fast inactivation of voltage-gated sodium channels, the stoichiometry of pannexin channels, the modulation of ion channel properties by glycosylation and toxins, and more 👉 rupress.org/jgp/collecti...

#SGP2025

Journal of General Physiology @jgp.org · Sep 6

What happened to the pursuit of truth? Eve Marder discusses a recent Viewpoint (rupress.org/jgp/article/... ) on the advent of #AI #LLM and their indiscriminate use to speed up the production of papers. rupress.org/jgp/article/...

📙 In JGP Highlights collection 2025: rupress.org/jgp/collecti...

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Journal of General Physiology @jgp.org · Sep 6

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers. From Smriti Gupta, Douglas Bayliss and colleagues: rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

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Journal of General Physiology @jgp.org · Sep 5

Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/...

#Evolution #IonChannels

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Journal of General Physiology @jgp.org · Sep 5

PANX1 hexamers work but cells prefer heptamers. Andrew Harris provides commentary on work from Gupta et al. (rupress.org/jgp/article/...): rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

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Journal of General Physiology @jgp.org · Sep 5

Yichen Liu and Francisco Bezanilla show that a sodium channel mutant removes fast inactivation with the inactivation particle bound rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

Journal of General Physiology @jgp.org · Sep 4

Hi1a reduces ischemic cell death by inhibiting ASIC1a channels. Berger & MacLean show each domain of Hi1a binds to the same site on ASIC1a subunits, accounting for this peptide’s unusual functional effects rupress.org/jgp/article/...

📙 JGP Highlights Collection 2025: rupress.org/jgp/collecti...

Journal of General Physiology @jgp.org · Sep 4

Wagner, Silva et al. @washuengineers.bsky.social show that deleting large sections of the Nav1.5 I–II linker does not affect voltage-dependent gating. But changes to the protein sequence does affect gating, showing how certain variants can alter channel function. rupress.org/jgp/article/...

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Journal of General Physiology @jgp.org · Sep 4

Beaudoin, Jackson et al. investigate the structural effects of N-linked glycosylation on Naᵥ channels using molecular modeling and dynamics simulations. rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

Journal of General Physiology @jgp.org · Sep 4

Resolving zone-specific regulation of cardiac #myosin. Shane Nelson @uvmvermont.bsky.social provides commentary on work from Pilagov et al. (rupress.org/jgp/article/...) that explores role of MyBP-C in regulation of the myosin SRX state in cardiac muscle. rupress.org/jgp/article/...

#Myofilaments

Journal of General Physiology @jgp.org · Sep 3

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

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Journal of General Physiology @jgp.org · Sep 3

Mercado-Perez, Beyder et al. show that some Piezo2 clusters in these cells interact with E-cadherin and #actin #cytoskeleton at the lateral wall. rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025