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Angelika Lampert @lampertlab.bsky.social · Sep 6

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

Oksana Iamshanova @iamshanovao.bsky.social · Sep 1

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.

🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.

💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd

💻 More info:
lnkd.in/eJw9pfMz

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Reposted by Angelika Lampert

Journal of General Physiology @jgp.org · Sep 3

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/...

📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti...

#SGP2025

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Angelika Lampert @lampertlab.bsky.social · Jun 18

Sodium channels and clinical pain: join the finale of worldwide sodium channel seminar series by Janneke Hoeijmakers on June 24! Still not enough of Nav research? Safe the date for the 2nd ww Nav channel conference Feb 4 to 6, 26 in Grindelwald CH⛰️. www.sodiumchannelseminars.org

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Angelika Lampert @lampertlab.bsky.social · Jun 18

Journal of General Physiology @jgp.org · Jun 3

Metaphors shape how we communicate & understand science, from genetic blueprints to molecular gates. Hull and @lampertlab.bsky.social‬ explore their role in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/...
#IonChannels

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Angelika Lampert @lampertlab.bsky.social · Jun 18

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is now out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading our article!

Journal of General Physiology @jgp.org · Jun 10

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism. New Viewpoint article from Peter Hull @fau.de‬ and Angelika Lampert @lampertlab.bsky.social @rwth.bsky.social: rupress.org/jgp/article/...

#VoltageGatedNaChannels #Biophysics #IonChannels

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Angelika Lampert @lampertlab.bsky.social · May 21

Slow inactivation of the fast sodium channel will be the topic of our next worldwide sodium channel seminar by Shimon Marom Tuesday May 27th on "Adaptive, slow sodium channel inactivation: impacts on neuronal excitability".
www.sodiumchannelseminars.org for link and infos. 🧠 🎓

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Angelika Lampert @lampertlab.bsky.social · Apr 29

happening today, Tuesday 29th of April!

Angelika Lampert @lampertlab.bsky.social · Apr 16

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Reposted by Angelika Lampert

Antonios Pantazis lab @antoniospantazis.bsky.social · Apr 13

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
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Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia

The present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the por...

www.jmcc-online.com

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Angelika Lampert @lampertlab.bsky.social · Apr 16

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

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Angelika Lampert @lampertlab.bsky.social · Mar 25

Happening today! See you there!

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Reposted by Angelika Lampert

Ted Price @tedpricethepainguy.bsky.social · Mar 12

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

Center for Advanced Pain Studies @utdpaincenter.bsky.social · Mar 12

📢 We're Hiring! Join Our Team at the Center for Advanced Pain Studies!

✨ CAPS is looking for a research technician. If you are passionate about research and studying chronic pain or migraine, this is your opportunity.

🔗 Learn more and apply: UTD.link/2v7

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Angelika Lampert @lampertlab.bsky.social · Mar 17

Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS

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Reposted by Angelika Lampert

@denklab @denklab.bsky.social · Feb 25

Join us in Berlin in September! It is going to be a great meeting for those of you interested in neuropathic pain, itch and related conditions! #Painresearch #PainScience 🧪🧠

International Association for the Study of Pain (IASP) @iasp.bsky.social · Feb 24

Time is Running out! Submit your poster abstract for #NeuPSIG2025 and present at the leading international pain meeting in Berlin this September. Submission Deadline: 3 March bit.ly/40r4Zz5 #PainScience #Neurology

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Angelika Lampert @lampertlab.bsky.social · Feb 12

Miriam Meisler will give our next #WWSC seminar on Feb 25th. Come and discuss Nav1.6 pathophysiology in epilepsy and treatment options: "Down-regulation of SCN8A by ASO or CRISPR-i prevents seizures in a GOF model".
Visit www.sodiumchannelseminar.org for info and link. See you there!

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Angelika Lampert @lampertlab.bsky.social · Feb 5

Thanks for the nice post!

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Reposted by Angelika Lampert

Journal of General Physiology @jgp.org · Jan 23

Commentary: Christian Jorgensen @jorlab123.bsky.social discusses new study from Elhanafy et al. (https://buff.ly/4haX9PQ) which shows how identical mutations in the voltage sensing domain of sodium channels can yield differential functional effects. https://buff.ly/4jpCRUD

#IonChannels

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Reposted by Angelika Lampert

Channelomics @channelomics.bsky.social · Jan 29

Nociceptor sodium #ionchannels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology @JGenPhysiol https://buff.ly/4hku7gH

#openaccess

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Angelika Lampert @lampertlab.bsky.social · Jan 30

5/5 When stepwise reducing Nav1.9, we see the shoulder disappear. It fits to the observation that CMi-fibers have broad APs doi.org/10.1101/2024... and high expression of Nav1.9. So, the shoulder of nociceptor APs may well be supported not only by Nav1.8 but also - suprisingly strongly - by Nav1.9.

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Angelika Lampert @lampertlab.bsky.social · Jan 30

4/5 We model a CMi-fiber (sleeping nociceptor) and an Adelta-fiber. In both, Nav1.9 significantly contributed to the fast upstroke of the AP and also to the shoulder formation. We can also nicely mimic Nav related disease pathology, like erythromelalgia, in the model.

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Angelika Lampert @lampertlab.bsky.social · Jan 30

3/5 What is the role of all those Navs during AP generation? Thomas Stiehl created a computer model in which we fed HH models of Navs, generated on our patch data, according to their expression revealed by transcriptomic data published by @dianatavf.bsky.social @tedpricethepainguy.bsky.social

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Angelika Lampert @lampertlab.bsky.social · Jan 30

2/5 We find that – not surprisingly – Nav1.8 activates and inactivates at more depolarized potentials compared to all the other Navs. Nav1.9 – recorded by Enrico Leipold – and Nav1.5 activate at the most hyperpolarized potentials. Nav1.9 has hugh window currents, and prominent persistent currents.

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Angelika Lampert @lampertlab.bsky.social · Jan 30

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.

Journal of General Physiology @jgp.org · Jan 21

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH

#Biophysics #Neuroscience #IonChannels

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Reposted by Angelika Lampert

Ted Price @tedpricethepainguy.bsky.social · Jan 22

and a 3rd BOOM! for today: www.biorxiv.org/content/10.1... Again on VGNaCs. Navs enter the PROTAC era!! Well done Alex Chamessian and @robgereau.bsky.social

Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain

The voltage-gated sodium channels (VGSC) NaV1.8 and NaV1.7 (NaVs) have emerged as promising and high-value targets for the development of novel, non-addictive analgesics to combat the chronic pain epi...

www.biorxiv.org

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Reposted by Angelika Lampert

Journal of General Physiology @jgp.org · Jan 21

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH

#Biophysics #Neuroscience #IonChannels

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Angelika Lampert @lampertlab.bsky.social · Jan 25

Thank you Ted! As always quick in catching new papers - this one is actually one i am really excited about. Thread to follow.

Ted Price @tedpricethepainguy.bsky.social · Jan 22

and one more BOOM! for today: rupress.org/jgp/article/... A comprehensive look at VGNaCs in DRG neurons from @lampertlab.bsky.social and colleagues with some interesting new ideas on Nav1.9.

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology | Rockefeller University Press

Köster et al. characterize eight sodium channel subtypes relevant to nociception and use a computer model to simulate the response of two types of nocicept

rupress.org

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