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Ted Price @tedpricethepainguy.bsky.social · 6h

Huge congrats to Sylvanus Toikumo for this outstanding work just published online preview in JCI: www.jci.org/articles/vie... We were happy to be able to play a small role in this paper, and I have been happy to be an informal co-mentor to Sylvanus... he is on the job market!

JCI - The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia

www.jci.org

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Ted Price @tedpricethepainguy.bsky.social · 2d

Just incredible findings, and a beautifully written paper: www.nature.com/articles/s41... Get your shingrix vaccine! You do not want peripheral neuropathy, and as a bonus you get substantial protection from later development of dementia.

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

www.nature.com

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Ted Price @tedpricethepainguy.bsky.social · 3d

Very convincing findings from the Gamper lab: www.jneurosci.org/content/45/3... somebody needs to figure out the source of this GABAergic tone within the DRG! As far as I can tell the origin of this remains speculative and needs molecular identification.

Peripheral Gating of Nociception Investigated with a Decerebrate, Arterially Perfused Preparation of the Rat

There is growing evidence that sensory neurons within the dorsal root ganglia (DRGs) are equipped with mechanisms for “gating” nociceptive information before it enters the central nervous system. Howe...

www.jneurosci.org

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Reposted by Ted Price

Simon Beggs @simonbeggslab.bsky.social · 4d

by predominance, take away the care of knowing causes; which is a lust of the mind, that by a perseverance of delight in the continual and indefatigable generation of knowledge, exceedeth the short vehemence of any carnal pleasure."

Written by a man not encumbered by an editor's word limit.

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Ted Price @tedpricethepainguy.bsky.social · 4d

Some of the best reasons there could ever be to support science.

Katie Mack @astrokatie.com · 4d

I think for me the most compelling answer for "why fund basic research?" (and the one most relevant to the people doing the work) is that humans are curious and finding stuff out makes us happy and fulfilled. Science is a thing humans like. Life would be more dull and sad if we didn't do it.

end/🧵

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Reposted by Ted Price

BK. Titanji @boghuma.bsky.social · 5d

Speaking for all physicians and healthcare providers here. When we see patients in need of care especially in an emergency room we do not leave them for dead. We do not care about their immigration status, we treat them because that is what we took an oath to do and is also basic human decency.

Aaron Rupar @atrupar.com · 5d

Leavitt: "When an illegal alien goes to the emergency room, who's paying for it? The American taxpayer."

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Ted Price @tedpricethepainguy.bsky.social · 5d

and spatial: discover.pennsieve.io/datasets/476

Spatial transcriptomics of human C2 dorsal root ganglia tissue from fusion surgeries - Pennsieve Discover

Visium spatial RNA sequencing was performed on 16 dorsal root ganglia from 8 patients (left and right of same level) undergoing C1-C2 fusion surgery.

discover.pennsieve.io

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Ted Price @tedpricethepainguy.bsky.social · 5d

Check out the datasets which are available for all - single cell: discover.pennsieve.io/datasets/475

Single nucleus sequencing of human C2 dorsal root ganglia tissue from fusion surgeries - Pennsieve Discover

Single nucleus RNA sequencing (10x) was performed on 12 dorsal root ganglia from 12 patients undergoing C1-C2 fusion surgery

discover.pennsieve.io

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Ted Price @tedpricethepainguy.bsky.social · 5d

@asta-at.bsky.social did an amazing job leading this study, a first of its kind for neck pain!

Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · 6d

The first publication of our project, which identifies altered gene expressions in the human DRG associated with neck pain. Fantastic collaboration with @tedpricethepainguy.bsky.social lab, Christoph Hofstetter from Neurosurgery, and a stellar team.
urldefense.com/v3/__https:/...

Transcriptome of the human C2 dorsal root ganglia in C1-2 arthrodesis surgery: insight for neck pain

Arendt-Tranholm et al. use surgically resected sensory ganglia to investigate the mechanisms underlying chronic neck pain. They produce a molecular map of

urldefense.com

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Reposted by Ted Price

AKA NickleDave @nicholdav.bsky.social · 7d

Biased because I spent almost a decade of my life here, but Emory Bio is a pretty dang good place to do neuro.

If you're looking for a TT position right now (Godspeed) you should apply

#neuroskyence

Anita Devineni @anitadevineni.bsky.social · 8d

My department at Emory is a hiring a tenure-track neuroscientist!

Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!

apply.interfolio.com/174371

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Ted Price

Ryan Marino, MD @ryanmarino.bsky.social · 7d

This is why we fund scientists to study things like oyster slobber even if you don’t think it sounds important

Leah McElrath @leahmcelrath.bsky.social · 9d

⚠️ Chinese researchers have invented bone glue that mimics how oysters stick to surfaces underwater.

The adhesive can reportedly repair orthopedic fractures in 2-3 minutes, even in blood-rich environments, and is bioabsorbable.

interestingengineering.com/science/chin...

China's oyster-inspired 'bone glue' bonds fractures in minutes

A new oyster-inspired Bone-02 adhesive can revolutionize bone repair without metal fasteners.

interestingengineering.com

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Ted Price @tedpricethepainguy.bsky.social · 8d

I think you are exactly right. I’m also convinced defunding research has the same aim, make it available for cheap investment by the rich to consolidate IP amongst the elites and lock inventors out of their own ability to commercialize according to their vision.

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Ted Price @tedpricethepainguy.bsky.social · 12d

Check out @jaydenobrien.bsky.social's great work on neuro-immune interactions in Guillain-Barre Syndrome (GBS) and how these might be involved in neuropathy that often occurs in individuals with the disease. Great collaboration with Erobo Ubogu at UAB
www.biorxiv.org/content/10.1...

Peripheral nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barr&eacute syndrome

Guillain-Barr&eacute syndrome (GBS) is an autoimmune disorder that causes weakness, sensory loss, autonomic dysfunction, and chronic neuropathic pain. The mediators responsible for driving early autoi...

www.biorxiv.org

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Ted Price @tedpricethepainguy.bsky.social · 12d

It’s a good point. In theory lost investment in biomedical research anywhere should have similar consequences on innovation in therapeutic development.

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Ted Price @tedpricethepainguy.bsky.social · 12d

Up until 2007

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Ted Price @tedpricethepainguy.bsky.social · 12d

are linked to NIH grants that are cut in our counterfactual scenario. We also found no evidence that linked drugs are less impactful, on the basis of our proxies for clinical and economic impact, than drugs that are not linked to at-risk grants."

Ted Price @tedpricethepainguy.bsky.social · 13d

"In some narrow cases, we can point to specific drugs that directly relied on NIH grants unlikely to be funded by NIH under a much smaller budget. But the benefits of NIH research in general are wide and diffuse. A very large number of advances—roughly one in two during the 21st century—

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Ted Price @tedpricethepainguy.bsky.social · 13d

I think this is a fascinating and creative way to think about budget cuts to NIH and what they would mean for all of our health: www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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Ted Price @tedpricethepainguy.bsky.social · 13d

www.jci.org/articles/vie...

JCI - An open letter to the NIH: value and costs in publishing

www.jci.org

Ted Price @tedpricethepainguy.bsky.social · 13d

Important letter from @jci-insight.bsky.social and JCI on open access fees. Agree on what JCI does and what their page charges accomplish for authors and readers. Sadly I don’t think this is the case for some other publishers that I won’t name.

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Reposted by Ted Price

Ewan St. John Smith @psalmotoxin.bsky.social · 13d

Kicking off with @tedpricethepainguy.bsky.social discussing insights from #PainResearch with human DRG & spinal cord. Great images & cool story out earlier this year on diabetic neuropathy led by @stephanie-shiers.bsky.social www.nature.com/articles/s41...

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Reposted by Ted Price

Rod Rahimi @rodrahimi.bsky.social · 14d

"An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients...Prof Tabrizi says this gene therapy 'is the beginning' and will open the gates for therapies that can reach more people."🧪⚕️

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.com

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Ted Price @tedpricethepainguy.bsky.social · 14d

This is incredible and so inspiring on so many levels. This is what science can do.

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Ted Price @tedpricethepainguy.bsky.social · 14d

Great stuff @schefflab.bsky.social

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 18d

Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer https://www.biorxiv.org/content/10.1101/2025.09.19.677339v1

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Reposted by Ted Price

derek guy @dieworkwear.bsky.social · 15d

my mom took tylenol when she was pregnant, which made me super focused on menswear and now i have a million followers on twitter

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