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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · 6d

The first publication of our project, which identifies altered gene expressions in the human DRG associated with neck pain. Fantastic collaboration with @tedpricethepainguy.bsky.social lab, Christoph Hofstetter from Neurosurgery, and a stellar team.
urldefense.com/v3/__https:/...

Transcriptome of the human C2 dorsal root ganglia in C1-2 arthrodesis surgery: insight for neck pain

Arendt-Tranholm et al. use surgically resected sensory ganglia to investigate the mechanisms underlying chronic neck pain. They produce a molecular map of

urldefense.com

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · 7d

A very exciting conference that brings together top scientists, clinicians, and biotech/industry experts to present emerging therapeutic targets for #ChronicPain. Learn more here: ter.li/unar77.

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Reposted by Michele Curatolo, MD, PhD

sher12.bsky.social @sher12.bsky.social · 12d

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Reposted by Michele Curatolo, MD, PhD

Ted Price @tedpricethepainguy.bsky.social · 14d

This is incredible and so inspiring on so many levels. This is what science can do.

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Sep 2

On #Biomarkers for #ChronicPain: Recent research shows that it not only about biological measures
www.michelecuratolomd.com/post/the-int...

Body and Mind Measures Interact to Improve Pain Biomarkers

New research highlights the benefits of combining biological and psychosocial measures when identifying biomarkers for pain. This supports the biopsychosocial model and urges a holistic approach to pa...

www.michelecuratolomd.com

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Reposted by Michele Curatolo, MD, PhD

Ted Price @tedpricethepainguy.bsky.social · Aug 16

This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disea...

www.biorxiv.org

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Aug 6

A short read on how #steroid #injections can help managing #ChronicPain, why they may be ineffective, and a frequently overlooked side effect they cause.
www.michelecuratolomd.com/post/steroid...

Steroid injections for chronic pain: How do they work (and why they may not)

Steroids are commonly administered via injection to help manage chronic pain. But how do they work, and why do they often seem ineffective?

www.michelecuratolomd.com

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Reposted by Michele Curatolo, MD, PhD

Chris Ashwood @cashwood.proteaglyco.com · Jul 15

A motivating quote from @carolynbertozzi.bskyverified.social:
“…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”

A personal message from 2022 chemistry laureate Carolyn Bertozzi to all young researchers on why to aspire to a career in science:

”I would want to share with them how a life in science is incredibly rewarding. It is rewarding because it is creative. You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations. And you created that. It has a permanence that ironically a physical object doesn’t have. You can paint a painting, but eventually it will fade. But knowledge doesn’t fade. Knowledge stays with us forever and it becomes the foundation for the next generations.”

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Reposted by Michele Curatolo, MD, PhD

Marisol Mancilla Moreno @marisolmancilla.bsky.social · Jun 26

Go check out our new paper on spatial transcriptomics of human sympathetic chain ganglia! Huge thanks @saadyousuf.bsky.social and @tedpricethepainguy.bsky.social for trusting me with this awesome project.

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · May 5

Our study that found associations of cerebrospinal fluid metabolites with #ChronicPain in patients with spinal muscle atrophy
#SMA #metabolism #metabolites
doi.org/10.1093/pm/p...

Cerebrospinal fluid metabolomics of pain in patients with spinal muscle atrophy

Dear Editor,

doi.org

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Apr 17

The protocol of our multi-omics study in patients with #LowBackPain and #Fibromyalgia. Great collaboration with Daniel Raftery's lab and Darrell Henze at Merck. Aims: to identify molecular pathways potentially involved in these conditions, and identify #biomarkers.
dx.plos.org/10.1371/jour...

Multi-omics profiles of chronic low back pain and fibromyalgia—Study protocol

Background Chronic low back pain (CLBP) and fibromyalgia (FM) are leading causes of suffering, disability, and social costs. Current pharmacological treatments do not target molecular mechanisms drivi...

dx.plos.org

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Reposted by Michele Curatolo, MD, PhD

Ted Price @tedpricethepainguy.bsky.social · Apr 15

Exciting new work on #suzetrigine effects on spontaneously active human DRG neurons from patients/donors with a pain history. Short story is that suzetrigine is remarkably effective at blocking spontaneous activity. Collab with Dougherty lab at MDACC!

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Apr 15

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons https://www.biorxiv.org/content/10.1101/2025.04.09.648014v1

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Reposted by Michele Curatolo, MD, PhD

bioRxivpreprint @biorxivpreprint.bsky.social · Apr 15

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons https://www.biorxiv.org/content/10.1101/2025.04.09.648014v1

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Reposted by Michele Curatolo, MD, PhD

Ted Price @tedpricethepainguy.bsky.social · Mar 31

Asta Arendt-Tranholm, @ish1789.bsky.social and others in our lab and the great team at UW led by @michelecuratolo.bsky.social latest preprint on mechanisms of neck pain in patients undergoing C1/C2 fusion surgery

bioRxivpreprint @biorxivpreprint.bsky.social · Mar 30

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain https://www.biorxiv.org/content/10.1101/2025.03.24.645122v1

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Mar 27

Remarkable finding by our colleagues at WashU @robgereau.bsky.social and collaborators, stressing how promising is #NIH support to our #PRECISIONPain Center to find mechanisms and effective treatments for #ChronicPain

Ted Price @tedpricethepainguy.bsky.social · Mar 27

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A

Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

www.biorxiv.org

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Reposted by Michele Curatolo, MD, PhD

Eric Topol @erictopol.bsky.social · Mar 26

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Mar 27

So much deserved @dianatavf.bsky.social !

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Mar 21

Chronic pain in older adults: Previous studies raised concerns about gabapentin + opioids causing death. New research sheds light on this.
#ChronicPain #Opioids

Pain management in seniors: Is gabapentin a death risk?

Gabapentin may not increase the risk of death when used with opioids, but its safety profile warrants cautious use.

www.michelecuratolomd.com

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Mar 12

A great opportunity to learn about #mechanisms of #pain from the intervertebral disc at #USASP2025.
#LowBackPain #ChronicPain #Research @utdpaincenter.bsky.social

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Reposted by Michele Curatolo, MD, PhD

Robert Gereau @robgereau.bsky.social · Mar 5

Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. www.nature.com/articles/s41...

A cryptic pocket in CB1 drives peripheral and functional selectivity - Nature

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolut...

www.nature.com

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Mar 6

Congratulations on this fantastic achievement!

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Feb 24

The FDA approval of @vertexpharm.bsky.social #suzetrigine is a groundbreaking development. Hopes for patients with pain, and a lesson to pain researchers.
#PainManagement #DrugDevelopment

www.michelecuratolomd.com/post/a-new-d...

New pain medication has been FDA-approved

In a groundbreaking development, the FDA has approved Vertex's suzetrigine for the treatment of moderate to severe acute pain. This approval marks the introduction of a pain medication to the market i...

www.michelecuratolomd.com

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Reposted by Michele Curatolo, MD, PhD

Ted Price @tedpricethepainguy.bsky.social · Feb 10

More terrific writing from @dereklowe.bsky.social on the ongoing saga between DOGE and NIH that is, in my opinion, trying to strangle the greatest biomedical research engine the world has ever known: www.science.org/content/blog...

The Continuing NIH/NSF Crisis, Part III: Indirect Costs

www.science.org

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Feb 10

Our scoping review on the mechanisms of #LowBackPain from the intervertebral disc, focusing only on human studies with pain outcome data, has identified an inflammatory-nociceptive feedback loop.
@tedpricethepainguy.bsky.social
www.jpain.org/article/S152...

Human molecular mechanisms of discogenic low back pain: A scoping review

The limited understanding of the mechanisms underlying human discogenic low back pain (DLBP) has hampered the development of effective treatments. While there is much research on disc degeneration, th...

www.jpain.org

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Michele Curatolo, MD, PhD @michelecuratolo.bsky.social · Jan 24

I have been skeptical about the effectiveness of muscle relaxants in chronic pain, but a new study changed by mind.
#ChronicPain #Medications
www.michelecuratolomd.com/post/muscle-...

Muscle Relaxants for Pain

Muscle relaxants can help manage chronic pain, but not reliably and not in all types of chronic pain.

www.michelecuratolomd.com

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