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Robert Gereau @robgereau.bsky.social · Aug 14

anesthesiology.wustl.edu/washu-medici...

WashU Medicine Anesthesiology shines at American Headache Society Meeting | Anesthesiology | Washington University School of Medicine in St. Louis

The Department of Anesthesiology at WashU Medicine showcased its leadership in migraine research at the 2025 American Headache Society Meeting with multiple podium presentations, featured sessions, an...

anesthesiology.wustl.edu

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Robert Gereau @robgereau.bsky.social · Jul 2

Congrats Ish! Well deserved.

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Robert Gereau @robgereau.bsky.social · Jul 2

Congrats Sebastian!

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Robert Gereau @robgereau.bsky.social · Jul 2

The end of an era as these 3 colleagues finish their tenure in the lab. Each the product of supportive programs to help them launch their journey and now off to med school, postdoc and grad school. Will miss you all but super excited for your future. Jakayla, Bobbie, Alexa - Go get em.

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Robert Gereau @robgereau.bsky.social · Jun 27

Outstanding

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Reposted by Robert Gereau

Ted Price @tedpricethepainguy.bsky.social · May 21

First time we’ve had the honor of the @dallasmorningnews.bsky.social writing about our scientific discoveries, funded by the #NIH www.dallasnews.com/news/2025/05...

UTD scientists solve 100-year-old mystery behind diabetic nerve damage

Nageotte nodules, once overlooked, may hold the key to understanding and treating diabetic peripheral neuropathy.

www.dallasnews.com

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Robert Gereau @robgereau.bsky.social · May 14

youtu.be/J25NJoe1B0g

The NIH HEAL Initiative–HEAL Is Hope

YouTube video by National Institutes of Health (NIH)

youtu.be

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Robert Gereau @robgereau.bsky.social · May 10

Excited to introduce Dr. Bobbie Brown, who happens to be our lab’s PhD #15. With co-mentor Bryan Copits.

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Robert Gereau @robgereau.bsky.social · Apr 1

Huge losses across the board - but for the US pain research and treatment community in particular this is a dark day.

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Robert Gereau @robgereau.bsky.social · Apr 1

Send good vibes to our colleagues at NIH folks.

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Reposted by Robert Gereau

Ted Price @tedpricethepainguy.bsky.social · Mar 27

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A

Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

www.biorxiv.org

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Reposted by Robert Gereau

Tim Behrens @behrenstimb.bsky.social · Mar 25

Science is under threat in the US. @elife.bsky.social have commissioned a series of articles discussing the implications and what we can do. The first three articles are now live. More to follow:
elifesciences.org/articles/106...
elifesciences.org/articles/106...
elifesciences.org/articles/106...

Science Under Threat in the United States: How scientists and institutions should respond

Individual researchers and university leaders need to make the case for science to their elected representatives and to the public at large.

elifesciences.org

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Reposted by Robert Gereau

jmoronconcepcion.bsky.social @jmoronconcepcion.bsky.social · Mar 10

New work from the lab published at @cp-neuron.bsky.social. In this study we dissect the role of hormonal regulation in pain-induced enhanced opioid intake in males.
Work conducted by the super talented @jessinbotham

www.cell.com/neuron/fullt...

Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...

www.cell.com

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Reposted by Robert Gereau

WashU Medicine @washumedicine.bsky.social · Mar 5

Opioids remain a common treatment for chronic pain — but at a cost. Now, scientists at WashU Medicine and Stanford University have developed a pain-relieving compound that mimics cannabis' benefits without the mind-altering side effects or risk of addiction. medicine.washu.edu/news/compoun...

Compound harnesses cannabis’ pain-relieving properties without side effects | WashU Medicine

Mouse study points to an effective alternative to opioids

medicine.washu.edu

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Robert Gereau @robgereau.bsky.social · Mar 5

We acknowledge and greatly appreciate financial support from the National Institutes of Health. Not only for the direct funding of this work, but for funding decades of foundational work that forms the knowledge base that enabled these recent advances. Without NIH funding this wouldn't have happened

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Robert Gereau @robgereau.bsky.social · Mar 5

This new class of agonists shows signaling bias, substantially improved peripheral restriction compared to previously reported "peripherally-restricted" CB1 ligands. The result is a dramatic reduction in analgesic tolerance and unwanted CNS-mediated side effects.

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Robert Gereau @robgereau.bsky.social · Mar 5

Led by the lab of Sush Majumdar, we worked with labs of Ron Dror, Kaavya Krishna Kumar, Michael Cameron, Amynhah Pradhan and Bryan Kobilka to develop a next-generation cannabinoid CB1 agonist

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Robert Gereau @robgereau.bsky.social · Mar 5

Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. www.nature.com/articles/s41...

A cryptic pocket in CB1 drives peripheral and functional selectivity - Nature

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolut...

www.nature.com

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Robert Gereau @robgereau.bsky.social · Mar 4

a bit of good news - thak you @jeremymberg.bsky.social for all of the information and insights!

Jeremy Berg @jeremymberg.bsky.social · Mar 4

Study Section meetings actually announced in the Federal Register today!

www.federalregister.gov/documents/20...

Center for Scientific Review; Notice of Closed Meetings

Search, browse and learn about the Federal Register. Federal Register 2.0 is the unofficial daily publication for rules, proposed rules, and notices of Federal agencies and organizations, as well as e...

www.federalregister.gov

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Reposted by Robert Gereau

Scott Delaney @scott-delaney.bsky.social · Feb 21

NIH indirects case update:

Hearing ongoing now, and I'll try to live tweet some notable exchanges.

Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:

(I'm paraphrasing here)

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Reposted by Robert Gereau

Ardem Patapoutian @ardemp.bskyverified.social · Feb 22

Check out the scientific journey behind the newest FDA-approved pain medication! 💊 Learn how NIH-funded research played a crucial role—both directly and indirectly—in bringing this breakthrough to life. 🧪

Jeremy Berg @jeremymberg.bsky.social · Feb 22

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.

This helps me remember what this is all about.

Ironically, it is about the treatment of pain.

the word irony is written on a white background

ALT: the word irony is written on a white background

media.tenor.com

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Robert Gereau @robgereau.bsky.social · Feb 21

Such an honor to get to work with this incredible group of humans. gereaulab.wustl.edu/people-page/

People

Principal Investigator Staff Members Research Faculty Postdoctoral Fellows Graduate Students Undergraduate Students

gereaulab.wustl.edu

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Robert Gereau @robgereau.bsky.social · Feb 21

Threats to science abound. It's been hard for everyone - but the energy in the lab today is incredible. Scientists brainstorming projects, pouring over exciting new data, companies vying to acquire licensing rights to patents we have for potential new #chronicpain treatments. So inspired by our team

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Reposted by Robert Gereau

Aubin Moutal @aubinmoutal.bsky.social · Feb 3

🚨 SAVE THE DATE! 🚨
2nd edition of the St. Louis Translational Pain Research Forum!
a joint effort between SLU, WashU and UHSP

🗓 Sept 26-27, 2025
🎤 Keynote: Dr. Cheryl Stucky
💡 Plenary: Dr. Patrick Dougherty
Register now ->🔗 stl-tprf2023.my.canva.site/stl-tprf2025

#PainResearch #Neuroskyience

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Robert Gereau @robgereau.bsky.social · Jan 30

A big day for pain care, and for pain science. www.fda.gov/news-events/...

FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain

The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.

www.fda.gov

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