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Aubin Moutal @aubinmoutal.bsky.social · 21h

I am very pround and thankful for all the lab members that lent their expertise to push this work over the finish line : @nicodumaire.bsky.social, @clemencegiere.bsky.social, Erin Vest, Haya Alkhateeb, and @libertym.bsky.social .
#TeamScience #PainResearch

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Aubin Moutal @aubinmoutal.bsky.social · 21h

This work is part of the PhD thesis of the now Dr. Lyuba Salih!
Her determination and creativity carried this project from concept to publication.
Huge thanks to Jafar Kafaie for his (real life) clinical insights and the French team for providing us with validated patient samples.

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Aubin Moutal @aubinmoutal.bsky.social · 21h

FGFR3-autoantibodies are not simple biomarkers.
We demonstrate a mechanism via extraceullar binding of autoantibodies to FGFR3 and how to block it.
We think targeting FGFR3 autoantibodies is a new therapeutic entry point for autoimmune neuropathies.
#Therapeutics #AutoimmunePain

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Aubin Moutal @aubinmoutal.bsky.social · 21h

We also had fun with a wide range of techniques from RNAscope and western blot on human DRG, to skin nerve-terminal fractionation, peptide arrays, CRISPR gene editing in cultured and in-vivo DRG.
All converging on one conclusion: FGFR3-autoantibodies bind FGFR3 to sensitize pain.
#CRISPR #HumanDRG

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Aubin Moutal @aubinmoutal.bsky.social · 21h

This manuscript marks a turning point for our lab's translational mission. With Dr. Jafar Kafaie, we obtained clinical measures of small fiber neuropathy patients with or without FGFR3-autoantibodies that informed back our mecanistic studies in the lab.
#TranslationalPain

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Aubin Moutal @aubinmoutal.bsky.social · 21h

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...

www.biorxiv.org

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Reposted by Aubin Moutal

Migraine Science Collaborative (MSC) @migrainecollab.bsky.social · 2d

MSC News: A US population-based analysis shows significant increases in chronic pain prevalence, and of high-impact chronic pain, after the pandemic. The upsurges were apparent for almost all pain sites considered in the study, including head/migraine pain.

migrainecollaborative.org/chronic-pain...

Chronic Pain Prevalence after the COVID-19 Pandemic: Troubling Findings - Migraine Science Collaborative

A new US population-based analysis shows significant increases in the prevalence of chronic pain, and of high-impact chronic pain, in the wake of the pandemic. The upsurges were apparent for almost al...

migrainecollaborative.org

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Reposted by Aubin Moutal

Ardem Patapoutian @ardemp.bskyverified.social · 3d

Attending #SfN2025 in San Diego☀️? Don’t miss the Dorris Neuroscience Center Symposium at @scripps.edu, happening right before the meeting. A great lineup of speakers to kick off your SfN week. Plan your trip accordingly and register for free here:
www.eventbrite.com/e/dorris-neu...

Please amplify!

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Reposted by Aubin Moutal

Christophe 🔬 L @christlet.bsky.social · 22d

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

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Reposted by Aubin Moutal

Kate Sadler @katesadlerphd.bsky.social · 23d

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

www.cell.com

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Reposted by Aubin Moutal

Ted Price @tedpricethepainguy.bsky.social · 26d

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

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Reposted by Aubin Moutal

Ted Price @tedpricethepainguy.bsky.social · Sep 3

Well, well, well: www.nature.com/articles/s41...

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol - Neuropsychopharmacology

Neuropsychopharmacology - Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol

www.nature.com

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Reposted by Aubin Moutal

Michalis Averof @michalis-averof.bsky.social · Sep 2

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

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Reposted by Aubin Moutal

Alles Lab @alleslab.bsky.social · Aug 28

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

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Aubin Moutal @aubinmoutal.bsky.social · Aug 28

That's awesome Congrats Sascha and Bryan !

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Reposted by Aubin Moutal

Ted Price @tedpricethepainguy.bsky.social · Aug 24

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

mheming.bsky.social @mheming.bsky.social · Aug 24

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

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Reposted by Aubin Moutal

mheming.bsky.social @mheming.bsky.social · Aug 24

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

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Reposted by Aubin Moutal

Diana Tavares Ferreira @dianatavf.bsky.social · Aug 19

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy

www.jci.org

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Aubin Moutal @aubinmoutal.bsky.social · Aug 18

CRMP2 expression and function is already validated in human lymphocytes from patients with HTLV1 and MS. Which brings a lot of translational relevance to this manuscript. It's all very exciting
academic.oup.com/jimmunol/art...
academic.oup.com/jimmunol/art...

Aubin Moutal @aubinmoutal.bsky.social · Aug 18

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

PAIN @painthejournal.bsky.social · Aug 18

Jiang et al. find that collapsin response mediator protein 2 phosphorylation in CD4+ T cells affects spinal infiltration and pain modulation, hinting at novel therapies for rheumatoid arthritis–related chronic pain. Learn more in #PAIN bit.ly/3HnqDO4

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Reposted by Aubin Moutal

Scheff Research Lab @schefflab.bsky.social · Aug 8

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...

Rethinking relief: Targeting sensory neurons to combat cancer and pain

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiolo...

www.cell.com

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

Buy the dip! 😂

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

We started with an observation from the clinic but ended with a model, a mechanism, and a path toward treatment.

Science is at its best when it closes the loop—from bench to bedside, and back again.

We’re proud of what this work uncovered—but even more excited about what it unlocks next!

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

I am grateful to all co-authors for their input and support.

This project was supported by funds from NINDS, The University of Arizona and Saint Louis University. Thanks to our funders for supporting high-risk, translational work.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

Lyuba Salih & Nicolas Dumaire at SLU took time off from their graduate projects to help close key experiments.

Jérôme Honnorat provided invaluable clinical insight and precious patient sera.

This project began with Rajesh Khanna, whose mentorship and support made the finish line possible.

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