Dr. Rajesh Khanna of the KhannaLabUF
@khannalabuf.bsky.social
We are unraveling a QR code for chronic pain | Prof. of Pharmacology & Therapeutics, Univ. of Florida COM | Director, Center for Advanced Pain Therapeutics and Research (CAPTOR) | Mayday Pain Fellow | 🇮🇳🇴🇲🇨🇦🇺🇸
ORCID: 0000-0002-9066-2969
ORCID: 0000-0002-9066-2969
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
🚀 NAPS applications open this week!
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
November 25, 2025 at 12:30 AM
🚀 NAPS applications open this week!
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 5:54 PM
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:25 PM
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Excited to share that the main work of my PhD has been published!
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
Controllability changes pain perception by increasing the precision of expectations
Nature Communications - Control over pain changes how intense it is perceived. Here, the authors show that this effect results from increased expectation precision with control, which changes...
rdcu.be
November 22, 2025 at 1:50 PM
Excited to share that the main work of my PhD has been published!
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Dont call it a payline grants.nih.gov/news-events/...
Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding
grants.nih.gov
November 21, 2025 at 5:23 PM
Dont call it a payline grants.nih.gov/news-events/...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
New preprint: Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgia www.biorxiv.org/content/10.1...
www.biorxiv.org
November 20, 2025 at 7:43 AM
New preprint: Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgia www.biorxiv.org/content/10.1...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 9:47 PM
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 2:46 PM
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Ready to talk to cells?
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
doi.org
November 11, 2025 at 12:52 PM
Ready to talk to cells?
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 15, 2025 at 4:15 PM
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
A Review in Nature Reviews Neuroscience synthesizes the progress in the understanding of the neural circuits that underlie itch signal processing, transmission and encoding within the central nervous system. go.nature.com/4p0V2ls 🔒
November 13, 2025 at 8:11 PM
A Review in Nature Reviews Neuroscience synthesizes the progress in the understanding of the neural circuits that underlie itch signal processing, transmission and encoding within the central nervous system. go.nature.com/4p0V2ls 🔒
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
November 12, 2025 at 6:19 PM
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Here's our accompanying review!
www.jneurosci.org/content/45/4...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
It is an all too common feature of academics, particularly grant funded scientist ones, to assume implicitly or explicitly that our systems select on pure merit. Right up until we, or our peeps, come up on the bad side of the dice roll. Only then is the system excoriated for being unfair.
November 7, 2025 at 4:59 PM
It is an all too common feature of academics, particularly grant funded scientist ones, to assume implicitly or explicitly that our systems select on pure merit. Right up until we, or our peeps, come up on the bad side of the dice roll. Only then is the system excoriated for being unfair.
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
November 7, 2025 at 9:00 PM
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
November 7, 2025 at 2:00 PM
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
New human DRG atlas just dropped! 🌟
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 11:26 AM
New human DRG atlas just dropped! 🌟
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Another excellent position at UT Dallas, this time in the Biological Science Dept: jobs.utdallas.edu/postings/30702 Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!
Open Rank Faculty Position Artificial Intelligence in Biological Sciences
Position DescriptionThe School of Natural Sciences and Mathematics at The University of Texas at Dallas (UT Dallas) seeks to fill multiple open-rank (Full, Associate, or Assistant Professor) tenured/t...
jobs.utdallas.edu
November 6, 2025 at 1:30 AM
Another excellent position at UT Dallas, this time in the Biological Science Dept: jobs.utdallas.edu/postings/30702 Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
November 5, 2025 at 9:45 PM
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
🚨 Mark your calendars for #NAPainSchool
🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more!
northamericanpainschool.com/registration/
#Pain #PainResearch #NPAW2025 #PrioritizePain
🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more!
northamericanpainschool.com/registration/
#Pain #PainResearch #NPAW2025 #PrioritizePain
November 4, 2025 at 8:50 PM
🚨 Mark your calendars for #NAPainSchool
🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more!
northamericanpainschool.com/registration/
#Pain #PainResearch #NPAW2025 #PrioritizePain
🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more!
northamericanpainschool.com/registration/
#Pain #PainResearch #NPAW2025 #PrioritizePain
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC
November 3, 2025 at 9:00 PM
Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC