Ted Price
@tedpricethepainguy.bsky.social
Dad, husband and pain scientist. Better guard me beyond the arc. Education should not cause debt
Reposted by Ted Price
Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Hierarchical organization of mechano-nociceptive pathways revealed by activity labeling
Noxious mechanical stimuli give rise to distinct percepts, from sharp cutaneous pain to diffuse visceral discomfort, yet the nociceptor ensembles that underlie these differences remain poorly defined....
www.biorxiv.org
December 14, 2025 at 6:25 PM
Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Ted Price
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
www.nature.com
December 11, 2025 at 5:54 PM
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Again, when will this stupidity end? This kind of ignorance makes life for all of our children worse through impacts on the environment and on the economy, but at some point one can only assume that’s what they want.
Doug Burgum lies that renewable energy is "worse for the planet, worse for the environment, and it drives up your electric prices"
December 11, 2025 at 4:54 PM
Again, when will this stupidity end? This kind of ignorance makes life for all of our children worse through impacts on the environment and on the economy, but at some point one can only assume that’s what they want.
Incredible. When does this end? Will Congress finally get serious about their jobs and stop this madness?
MAGAZINER: How many veterans have you deported?
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
NOEM: We haven't deported veterans
MAGAZINER: We are now joined on Zoom by a combat veteran you deported to Korea
December 11, 2025 at 4:51 PM
Incredible. When does this end? Will Congress finally get serious about their jobs and stop this madness?
Reposted by Ted Price
Center for Pain Therapeutics and Addiction Research. @uthealthsa.bsky.social is searching for a tenure-track faculty recruit. Outstanding Envt and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectminds.com/faculty/jobs...
CPTAR - Open Rank (Assistant/Associate/Professor) in San Antonio
The University of Texas Health Science Center San Antonio, School Dentistry, is seeking applications for a full-time position of a tenure...
uthscsa.referrals.selectminds.com
December 10, 2025 at 11:09 PM
Center for Pain Therapeutics and Addiction Research. @uthealthsa.bsky.social is searching for a tenure-track faculty recruit. Outstanding Envt and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectminds.com/faculty/jobs...
Look at us lovebirds
Haven’t been to New Orleans in too long
Haven’t been to New Orleans in too long
December 10, 2025 at 11:03 PM
Look at us lovebirds
Haven’t been to New Orleans in too long
Haven’t been to New Orleans in too long
Bro, the explanation is you’re getting old. www.espn.com/nfl/story/_/...
Kelce: Stumped trying to find fix for performance
Travis Kelce said on the "New Heights" podcast that he is struggling to find the answers for his play this season.
www.espn.com
December 10, 2025 at 6:32 PM
Bro, the explanation is you’re getting old. www.espn.com/nfl/story/_/...
Awesome!!
Assuaging Pain. An acetaminophen/codeine pill. DIY 75% ethanol as a solvent for the analgesics and other soluble components of the pill. This is a speck-sized patch of the microscope slide on which I recrystallized the pharma chems. Looks to me like a waterfall lit with dappled sunlight.
December 8, 2025 at 9:05 PM
Awesome!!
Wild indeed!
Well this is pretty wild
[🎁]
[🎁]
The Married Scientists Torn Apart by a Covid Bioweapon Theory
www.nytimes.com
December 7, 2025 at 4:15 PM
Wild indeed!
Reposted by Ted Price
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 6, 2025 at 5:02 PM
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Reposted by Ted Price
🧠📢 New preprint alert
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
December 5, 2025 at 8:42 PM
🧠📢 New preprint alert
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵
#neuroskyence #compneurosky
Reposted by Ted Price
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
December 4, 2025 at 7:41 PM
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
Reposted by Ted Price
Updates to the submission process for LOIs and grants requesting more than $500K in any budget periods. grants.nih.gov/grants/guide...
NOT-OD-26-019: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Intent and Unsolicited Applications Requesting $500,000 or More in Dire...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Inten...
grants.nih.gov
December 3, 2025 at 6:19 PM
Updates to the submission process for LOIs and grants requesting more than $500K in any budget periods. grants.nih.gov/grants/guide...
Reposted by Ted Price
Lambert High School in Georgia was the only U.S. school to place in the high school top 10 at iGEM, an international synthetic biology competition. The other top teams included one from South Korea, one from Taiwan, and seven from China. cbsn.ws/4otdEKq
December 1, 2025 at 1:05 AM
Lambert High School in Georgia was the only U.S. school to place in the high school top 10 at iGEM, an international synthetic biology competition. The other top teams included one from South Korea, one from Taiwan, and seven from China. cbsn.ws/4otdEKq
Great story about some amazing young scientists and an important message on failing leadership in America
“They are so smart I can’t keep up,” says Kate Sharer, biotechnology teacher at Lambert High School in Suwanee, Georgia. “Because they are still teenagers, so they're thinking so far out of the box.” cbsn.ws/48mMTRB
December 1, 2025 at 1:06 AM
Great story about some amazing young scientists and an important message on failing leadership in America
This is really impressive stuff.
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission www.nature.com/articles/d41...
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.
www.nature.com
November 29, 2025 at 9:22 PM
This is really impressive stuff.
So many of the peptide receptor targets I learned about from Victor Hruby, Josef Vagner, and Robin Polt (none of whom are involved in this exciting work) when I was at UA now zooming toward the clinic www.biorxiv.org/content/10.1...
Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates
The melanocortin system plays a central role in regulating hunger and satiety, making it an attractive target for treating metabolic disease. However, the limited clinical success of selective melanoc...
www.biorxiv.org
November 29, 2025 at 5:07 PM
So many of the peptide receptor targets I learned about from Victor Hruby, Josef Vagner, and Robin Polt (none of whom are involved in this exciting work) when I was at UA now zooming toward the clinic www.biorxiv.org/content/10.1...
Happy Thanksgiving!
November 28, 2025 at 1:53 AM
Happy Thanksgiving!
This is so true. Academics are totally committed to creating meaningless work for ourselves.
Begging PhD programs to agree on a common app with only letters of rec that writers upload once. These inane likert scales when students are applying to 15-20 programs is destroying my soul
November 27, 2025 at 5:43 PM
This is so true. Academics are totally committed to creating meaningless work for ourselves.
Reposted by Ted Price
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
November 24, 2025 at 12:59 AM
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
I agree that this is a tragedy. The pessimistic part of me thinks this is intentional because they want all biotech scientific founders to be beholden to rich investors at lower valuations.
November 21, 2025 at 7:48 PM
I agree that this is a tragedy. The pessimistic part of me thinks this is intentional because they want all biotech scientific founders to be beholden to rich investors at lower valuations.
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
Reposted by Ted Price
Kelly: "I never expected after serving 25 years in the Navy flying combat missions over Iraq and Kuwait, flying the Space Shuttle, that now I've got to worry about my personal safety and that of my wife, Gabby Giffords, who was already nearly assassinated, because of something the president said."
November 21, 2025 at 2:08 AM
Kelly: "I never expected after serving 25 years in the Navy flying combat missions over Iraq and Kuwait, flying the Space Shuttle, that now I've got to worry about my personal safety and that of my wife, Gabby Giffords, who was already nearly assassinated, because of something the president said."
This is totally nuts. Also, not a good idea to piss off every nurse in the nation.
November 21, 2025 at 2:08 AM
This is totally nuts. Also, not a good idea to piss off every nurse in the nation.
Reposted by Ted Price
Want to flow-analyze or FACS your sensory neurons without relying on reporter mice? Check out our new short report 👇https://www.biorxiv.org/content/10.1101/2025.11.19.688847v1
A novel method to sort and enrich sensory neurons
Peripheral sensory neurons, residing in the dorsal root ganglia (DRG), relay sensory information from the periphery to the central nervous system. Although single-cell transcriptomic studies have iden...
www.biorxiv.org
November 20, 2025 at 7:29 AM
Want to flow-analyze or FACS your sensory neurons without relying on reporter mice? Check out our new short report 👇https://www.biorxiv.org/content/10.1101/2025.11.19.688847v1