Prof Danny Altmann
@daltmann.bsky.social
Professor of Immunology, Imperial College London. Editor of OUP Oxford Open Immunology. Co-author - Penguin Long Covid Handbook. Discusses: Covid-19, Long Covid, T cells, immunogenetics and HLA, respiratory infection, science policy, arboviruses, C19th lit
Pinned
Dipping toe in the water after many years at the other place, trying the transition. Mainly aiming to discuss exciting stuff happening in immunology research, including but not only responses in Covid-19 and Long Covid. Please follow if this could be of interest
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity: Immunity www.cell.com/immunity/ful...
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity
Lucas et al. evaluate the interferon-gamma (IFN-γ) signature against toxicity and
efficacy in four neoadjuvant melanoma immunotherapy regimens. IFN-γ-high scores associated
with overall favorable effi...
www.cell.com
January 14, 2026 at 9:12 AM
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity: Immunity www.cell.com/immunity/ful...
Reposted by Prof Danny Altmann
"CAR-T therapy has been available on the NHS for several years for certain types of leukaemia and lymphoma but has only now been extended to adults with B-cell ALL."
#genetherapy #celltherapy
www.bbc.co.uk/news/article...
#genetherapy #celltherapy
www.bbc.co.uk/news/article...
First leukaemia patient to get pioneering drug on NHS says it is 'very sci-fi'
Oscar Murphy has an aggressive form of the blood cancer and is the first to get CAR-T therapy in the UK.
www.bbc.co.uk
January 14, 2026 at 7:38 AM
"CAR-T therapy has been available on the NHS for several years for certain types of leukaemia and lymphoma but has only now been extended to adults with B-cell ALL."
#genetherapy #celltherapy
www.bbc.co.uk/news/article...
#genetherapy #celltherapy
www.bbc.co.uk/news/article...
Reposted by Prof Danny Altmann
Great to see two papers out that show the benefits of RSV vaccination (monoclonal treatment) to prevent severe RSV infection. A quick thread to unpick what these vaccines are as there are 2 quite different products in clinical use and it can be confusing what the terminology means. #HealthPolicy 🧵
Universal nirsevimab slashes RSV infant hospitalizations, study suggests
www.cidrap.umn.edu
January 14, 2026 at 8:20 AM
Great to see two papers out that show the benefits of RSV vaccination (monoclonal treatment) to prevent severe RSV infection. A quick thread to unpick what these vaccines are as there are 2 quite different products in clinical use and it can be confusing what the terminology means. #HealthPolicy 🧵
Reposted by Prof Danny Altmann
Monoclonal antibody Lu AG09222 decreased monthly migraine days:
www.nejm.org/doi/full/10.... #LongCovid
www.nejm.org/doi/full/10.... #LongCovid
A Monoclonal Antibody to PACAP for Migraine Prevention | NEJM
Targeting pituitary adenylate cyclase–activating polypeptide (PACAP) is a new avenue
for treating migraine. The efficacy and safety of intravenous Lu AG09222, a humanized
monoclonal antibody direct...
www.nejm.org
January 8, 2026 at 9:28 PM
Monoclonal antibody Lu AG09222 decreased monthly migraine days:
www.nejm.org/doi/full/10.... #LongCovid
www.nejm.org/doi/full/10.... #LongCovid
Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...
Chinese Immune Multi-Omics Atlas
Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...
www.science.org
January 8, 2026 at 10:46 PM
Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs,
known as melanosomes, that directly engage and impair CD8+ T cell receptors.
www.cell.com
January 8, 2026 at 4:54 PM
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...
Reposted by Prof Danny Altmann
Just published on @pnas.org how #COVID can lead to loss of dopamine neurons. In mice, it can be mitigated with proper treatment, but in humans we don't know yet. Below you see the reduction of TH (rate-limiting enzyme to produce dopamine) in the brain. This is #LongCovid and also viral Parkinsonism.
January 8, 2026 at 3:09 PM
Just published on @pnas.org how #COVID can lead to loss of dopamine neurons. In mice, it can be mitigated with proper treatment, but in humans we don't know yet. Below you see the reduction of TH (rate-limiting enzyme to produce dopamine) in the brain. This is #LongCovid and also viral Parkinsonism.
Reposted by Prof Danny Altmann
IL-17REL disarms inflammation
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
IL-17REL disarms inflammation
Nature Immunology - A newly identified, TGFβ-inducible decoy receptor for IL-17 family cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid...
www.nature.com
January 6, 2026 at 11:17 AM
IL-17REL disarms inflammation
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
Reposted by Prof Danny Altmann
Your fact of the day:
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
Fowl Play: How US Chicken Imports will Pollute Britain's Poor
Since joining the EU British food has gone from bog-awful to top-notch, but Otto English reveals how a US Trade deal will unravel 40 years of progress.
bylinetimes.com
January 4, 2026 at 9:12 AM
Your fact of the day:
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
Assumption comes from a series of excellent, big data papers on reduced risk associated with zoster vaccination
Must admit I didn’t know there was a direct correlation between chicken pox and Alzheimer’s in later life.
January 3, 2026 at 12:08 PM
Assumption comes from a series of excellent, big data papers on reduced risk associated with zoster vaccination
I’m excited about the real-life experimental medicine question of whether this will reduce risk of future Alzheimer’s?
January 3, 2026 at 11:51 AM
I’m excited about the real-life experimental medicine question of whether this will reduce risk of future Alzheimer’s?
Reposted by Prof Danny Altmann
Happy 2026!!!
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
January 2, 2026 at 3:59 PM
Happy 2026!!!
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
Reposted by Prof Danny Altmann
We don't know if the BA.3.2.2 saltation will mirror BA.2.86>JN1.
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
December 31, 2025 at 11:08 AM
We don't know if the BA.3.2.2 saltation will mirror BA.2.86>JN1.
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
…but so frustrating and impossible to get tickets! Needs some proper dates with a ticket website that doesn’t just put you on hold..
I'm not sure I've ever been to a gig quite like Ben Watt and Tracey Thorn at The Moth Club last night. Here's why.
Tracey Thorn and Ben Watt at The Moth Club, Hackney: “Two cosmic serendipities threw down a line that started in 1982 and continued unbroken into last night.” | Pete Paphides
Get more from Pete Paphides on Patreon
www.patreon.com
December 24, 2025 at 2:24 PM
…but so frustrating and impossible to get tickets! Needs some proper dates with a ticket website that doesn’t just put you on hold..
Reposted by Prof Danny Altmann
Looks like flu is wave is likely to be "normal bad" shifted earlier and not bigger this year after all.
Latest hospital data came out this afternoon.
Latest hospital data came out this afternoon.
December 18, 2025 at 5:19 PM
Looks like flu is wave is likely to be "normal bad" shifted earlier and not bigger this year after all.
Latest hospital data came out this afternoon.
Latest hospital data came out this afternoon.
Reposted by Prof Danny Altmann
Radio 4’s Jane Austen season is absolutely brilliant and wonderful. There is nothing like Radio 4 anywhere in the world, it is so precious.
December 19, 2025 at 11:18 AM
Radio 4’s Jane Austen season is absolutely brilliant and wonderful. There is nothing like Radio 4 anywhere in the world, it is so precious.
Reassessing sotrovimab's role in COVID-19: insights and implications - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Reassessing sotrovimab's role in COVID-19: insights and implications
The development of anti-spike monoclonal antibodies by pharmaceutical manufacturers
during the COVID-19 pandemic was an unprecedented effort that helped save thousands
of lives. In this issue of The L...
www.thelancet.com
December 18, 2025 at 2:31 PM
Reassessing sotrovimab's role in COVID-19: insights and implications - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Restoring youth to old immune cells: mRNA therapy turns back the clock www.nature.com/articles/d41...
Restoring youth to old immune cells: mRNA therapy turns back the clock
Testing in mice suggests that rejuvenating T cells could make vaccines and some cancer therapies more effective.
www.nature.com
December 18, 2025 at 2:24 PM
Restoring youth to old immune cells: mRNA therapy turns back the clock www.nature.com/articles/d41...
Gene editing cuts blood cholesterol levels in small study | Science | AAAS www.science.org/content/arti...
Gene editing cuts blood cholesterol levels in small study
In 15 patients, infusion of CRISPR treatment lowered amounts of two artery-clogging fats
www.science.org
December 18, 2025 at 11:13 AM
Gene editing cuts blood cholesterol levels in small study | Science | AAAS www.science.org/content/arti...
Job links for those posts with our team:
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
December 18, 2025 at 10:59 AM
Job links for those posts with our team:
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Will aim to load them separately
December 18, 2025 at 10:55 AM
Will aim to load them separately