Prof Danny Altmann
@daltmann.bsky.social
Professor of Immunology, Imperial College London. Editor of OUP Oxford Open Immunology. Co-author - Penguin Long Covid Handbook. Discusses: Covid-19, Long Covid, T cells, immunogenetics and HLA, respiratory infection, science policy, arboviruses, C19th lit
Pinned
Dipping toe in the water after many years at the other place, trying the transition. Mainly aiming to discuss exciting stuff happening in immunology research, including but not only responses in Covid-19 and Long Covid. Please follow if this could be of interest
Reposted by Prof Danny Altmann
Monoclonal antibody Lu AG09222 decreased monthly migraine days:
www.nejm.org/doi/full/10.... #LongCovid
www.nejm.org/doi/full/10.... #LongCovid
A Monoclonal Antibody to PACAP for Migraine Prevention | NEJM
Targeting pituitary adenylate cyclase–activating polypeptide (PACAP) is a new avenue
for treating migraine. The efficacy and safety of intravenous Lu AG09222, a humanized
monoclonal antibody direct...
www.nejm.org
January 8, 2026 at 9:28 PM
Monoclonal antibody Lu AG09222 decreased monthly migraine days:
www.nejm.org/doi/full/10.... #LongCovid
www.nejm.org/doi/full/10.... #LongCovid
Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...
Chinese Immune Multi-Omics Atlas
Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...
www.science.org
January 8, 2026 at 10:46 PM
Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs,
known as melanosomes, that directly engage and impair CD8+ T cell receptors.
www.cell.com
January 8, 2026 at 4:54 PM
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...
Reposted by Prof Danny Altmann
Just published on @pnas.org how #COVID can lead to loss of dopamine neurons. In mice, it can be mitigated with proper treatment, but in humans we don't know yet. Below you see the reduction of TH (rate-limiting enzyme to produce dopamine) in the brain. This is #LongCovid and also viral Parkinsonism.
January 8, 2026 at 3:09 PM
Just published on @pnas.org how #COVID can lead to loss of dopamine neurons. In mice, it can be mitigated with proper treatment, but in humans we don't know yet. Below you see the reduction of TH (rate-limiting enzyme to produce dopamine) in the brain. This is #LongCovid and also viral Parkinsonism.
Reposted by Prof Danny Altmann
IL-17REL disarms inflammation
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
IL-17REL disarms inflammation
Nature Immunology - A newly identified, TGFβ-inducible decoy receptor for IL-17 family cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid...
www.nature.com
January 6, 2026 at 11:17 AM
IL-17REL disarms inflammation
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity.
www.nature.com/artic...
1/5
Reposted by Prof Danny Altmann
Your fact of the day:
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
Fowl Play: How US Chicken Imports will Pollute Britain's Poor
Since joining the EU British food has gone from bog-awful to top-notch, but Otto English reveals how a US Trade deal will unravel 40 years of progress.
bylinetimes.com
January 4, 2026 at 9:12 AM
Your fact of the day:
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132.
bylinetimes.com/2020/02/28/f...
Assumption comes from a series of excellent, big data papers on reduced risk associated with zoster vaccination
Must admit I didn’t know there was a direct correlation between chicken pox and Alzheimer’s in later life.
January 3, 2026 at 12:08 PM
Assumption comes from a series of excellent, big data papers on reduced risk associated with zoster vaccination
I’m excited about the real-life experimental medicine question of whether this will reduce risk of future Alzheimer’s?
January 3, 2026 at 11:51 AM
I’m excited about the real-life experimental medicine question of whether this will reduce risk of future Alzheimer’s?
Reposted by Prof Danny Altmann
Happy 2026!!!
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
January 2, 2026 at 3:59 PM
Happy 2026!!!
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!
bit.ly/SciImm_free
#ScienceImmuno10gy
Reposted by Prof Danny Altmann
We don't know if the BA.3.2.2 saltation will mirror BA.2.86>JN1.
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
December 31, 2025 at 11:08 AM
We don't know if the BA.3.2.2 saltation will mirror BA.2.86>JN1.
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact.
For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50.
BA.3.2.2 is off the map, but apparently all is well...
…but so frustrating and impossible to get tickets! Needs some proper dates with a ticket website that doesn’t just put you on hold..
I'm not sure I've ever been to a gig quite like Ben Watt and Tracey Thorn at The Moth Club last night. Here's why.
Tracey Thorn and Ben Watt at The Moth Club, Hackney: “Two cosmic serendipities threw down a line that started in 1982 and continued unbroken into last night.” | Pete Paphides
Get more from Pete Paphides on Patreon
www.patreon.com
December 24, 2025 at 2:24 PM
…but so frustrating and impossible to get tickets! Needs some proper dates with a ticket website that doesn’t just put you on hold..
Reposted by Prof Danny Altmann
Looks like flu is wave is likely to be "normal bad" shifted earlier and not bigger this year after all.
Latest hospital data came out this afternoon.
Latest hospital data came out this afternoon.
December 18, 2025 at 5:19 PM
Looks like flu is wave is likely to be "normal bad" shifted earlier and not bigger this year after all.
Latest hospital data came out this afternoon.
Latest hospital data came out this afternoon.
Reposted by Prof Danny Altmann
Radio 4’s Jane Austen season is absolutely brilliant and wonderful. There is nothing like Radio 4 anywhere in the world, it is so precious.
December 19, 2025 at 11:18 AM
Radio 4’s Jane Austen season is absolutely brilliant and wonderful. There is nothing like Radio 4 anywhere in the world, it is so precious.
Reassessing sotrovimab's role in COVID-19: insights and implications - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Reassessing sotrovimab's role in COVID-19: insights and implications
The development of anti-spike monoclonal antibodies by pharmaceutical manufacturers
during the COVID-19 pandemic was an unprecedented effort that helped save thousands
of lives. In this issue of The L...
www.thelancet.com
December 18, 2025 at 2:31 PM
Reassessing sotrovimab's role in COVID-19: insights and implications - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Restoring youth to old immune cells: mRNA therapy turns back the clock www.nature.com/articles/d41...
Restoring youth to old immune cells: mRNA therapy turns back the clock
Testing in mice suggests that rejuvenating T cells could make vaccines and some cancer therapies more effective.
www.nature.com
December 18, 2025 at 2:24 PM
Restoring youth to old immune cells: mRNA therapy turns back the clock www.nature.com/articles/d41...
Gene editing cuts blood cholesterol levels in small study | Science | AAAS www.science.org/content/arti...
Gene editing cuts blood cholesterol levels in small study
In 15 patients, infusion of CRISPR treatment lowered amounts of two artery-clogging fats
www.science.org
December 18, 2025 at 11:13 AM
Gene editing cuts blood cholesterol levels in small study | Science | AAAS www.science.org/content/arti...
Job links for those posts with our team:
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
December 18, 2025 at 10:59 AM
Job links for those posts with our team:
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Come and join us at Imperial College to work a project looking at mechanisms in Long Covid and ME/CFS
We're looking for:
A keen, experienced Research Nurse
A gifted molecular immunologist with a strong bioinformatics background
www.imperial.ac.uk/.../descript....
www.imperial.ac.uk/.../descript....
We're looking for:
A keen, experienced Research Nurse
A gifted molecular immunologist with a strong bioinformatics background
www.imperial.ac.uk/.../descript....
www.imperial.ac.uk/.../descript....
www.imperial.ac.uk
December 18, 2025 at 10:48 AM
Come and join us at Imperial College to work a project looking at mechanisms in Long Covid and ME/CFS
We're looking for:
A keen, experienced Research Nurse
A gifted molecular immunologist with a strong bioinformatics background
www.imperial.ac.uk/.../descript....
www.imperial.ac.uk/.../descript....
We're looking for:
A keen, experienced Research Nurse
A gifted molecular immunologist with a strong bioinformatics background
www.imperial.ac.uk/.../descript....
www.imperial.ac.uk/.../descript....
www.newscientist.com/article/2508...
Excellent piece including update on ME/CFS genetics and on our 'Rosetta' project on Long Covid and ME/CFS
Excellent piece including update on ME/CFS genetics and on our 'Rosetta' project on Long Covid and ME/CFS
Chronic fatigue syndrome seems to have a very strong genetic element
The largest study so far into the genetics of chronic fatigue syndrome, or myalgic encephalomyelitis, has implicated 259 genes – six times more than those identified just four months ago
www.newscientist.com
December 18, 2025 at 9:49 AM
www.newscientist.com/article/2508...
Excellent piece including update on ME/CFS genetics and on our 'Rosetta' project on Long Covid and ME/CFS
Excellent piece including update on ME/CFS genetics and on our 'Rosetta' project on Long Covid and ME/CFS
Reposted by Prof Danny Altmann
Seven feel-good science stories to round up 2025. All too often we forget to celebrate the positives
🧪
#AcademicSky
www.nature.com/articles/d41...
🧪
#AcademicSky
www.nature.com/articles/d41...
Seven feel-good science stories to restore your faith in 2025
Immense progress in gene-editing, drug discovery and conservation are just some of the reasons to be cheerful about 2025.
www.nature.com
December 18, 2025 at 8:15 AM
Seven feel-good science stories to round up 2025. All too often we forget to celebrate the positives
🧪
#AcademicSky
www.nature.com/articles/d41...
🧪
#AcademicSky
www.nature.com/articles/d41...
Reposted by Prof Danny Altmann
The CDC has endorsed ACIP’s decision of revoking universal access in USA to hepatitis B vaccines at birth. The policy had been in place for 34y and was changed despite no new evidence emerging of any risk of vaccination. #HealthPolicy 🧵
CDC accepts ACIP’s hepatitis B vaccine recommendations for babies
The CDC also said if a baby is not receiving a birth dose of vaccine, the initial dose should be administered no earlier than 2 months of age.
www.cidrap.umn.edu
December 18, 2025 at 8:08 AM
The CDC has endorsed ACIP’s decision of revoking universal access in USA to hepatitis B vaccines at birth. The policy had been in place for 34y and was changed despite no new evidence emerging of any risk of vaccination. #HealthPolicy 🧵
Get your flu vaccine and protect Gran at Xmas👇
December 17, 2025 at 3:05 PM
Get your flu vaccine and protect Gran at Xmas👇