Covid-19 is not just a respiratory infection. Cardiovascular symptoms are seen in both acute and long covid. Katharine Lang reports on what we’ve learnt since the onset of the pandemic Cardiovascular complications from covid-19 have been seen widely since the early days of the pandemic, when a small study in Wuhan reported myocardial injury in several patients.1 Soon after, studies found that up to 30% of those admitted to intensive care units showed myocardial injury.23 “In many respects covid-19 is a vascular disease masquerading as a respiratory one,” says Andy Benest, vascular biologist at the University of Nottingham. Although covid is transmitted through the respiratory system, much of the pathology unfolds in the vascular system, with microvascular damage, thromboinflammation, and dysregulated perfusion underpinning the cardiac, pulmonary, and neurological manifestations of severe disease. “The virus enters through the airways but exerts its systemic effects through the vasculature, the common denominator in the lungs, heart, kidneys, and brain,” Benest tells The BMJ . Cardiovascular complications are relatively common in the acute phase of covid. Studies have found that acute cardiac injury occurred in 6-25% of people admitted to hospital with covid.4 One 2020 study reported that 14.1% of people admitted to hospital with covid experienced some type of cardiovascular complication.5 Early studies suggested that the endothelium …

Two little‑known animal viruses are worth watching in 2026 and beyond: Influenza D (common in cattle) and a dog coronavirus called CCoV‑HuPn‑2018.

Although recent studies have suggested that the Omicron strain is less severe, the prevalence of long Omicron variants and their subvariant waves continues today. Here, we analyze the pathological characteristics of SARS-CoV-2 variants in cynomolgus macaques. Prolonged re-challenge analysis results in the establishment of re-infection in some macaques with both the same strain and different strains. Omicron infection shows low pathogenicity; however, all macaques that developed pneumonia were inoculated with Omicron strains at the second inoculation. Interestingly, antibodies against the Wuhan, Alpha, and Delta strains are strongly induced regardless of the strain, but antibodies against Omicron strains are not. Moreover, despite the re-infection strain, antibody levels against the Wuhan strain are highest, suggesting original antigenic sin. In addition, Omicron infection induces weaker antigen-specific T-cell responses. These results indicate that immune responses to viral infection differ between the variants, and these differences could inform vaccine development strategies. Investigation of SARS-CoV-2 variants using a COVID-19 monkey model reveals heterogeneous immune responses to viral infection, which may inform future vaccine strategies and public health control.

The department has sent Google, Meta and other companies hundreds of subpoenas for information on accounts that track or comment on Immigration and Customs Enforcement, officials and tech workers said.

Although recent studies have suggested that the Omicron strain is less severe, the prevalence of long Omicron variants and their subvariant waves continues today. Here, we analyze the pathological characteristics of SARS-CoV-2 variants in cynomolgus macaques. Prolonged re-challenge analysis results in the establishment of re-infection in some macaques with both the same strain and different strains. Omicron infection shows low pathogenicity; however, all macaques that developed pneumonia were inoculated with Omicron strains at the second inoculation. Interestingly, antibodies against the Wuhan, Alpha, and Delta strains are strongly induced regardless of the strain, but antibodies against Omicron strains are not. Moreover, despite the re-infection strain, antibody levels against the Wuhan strain are highest, suggesting original antigenic sin. In addition, Omicron infection induces weaker antigen-specific T-cell responses. These results indicate that immune responses to viral infection differ between the variants, and these differences could inform vaccine development strategies. Investigation of SARS-CoV-2 variants using a COVID-19 monkey model reveals heterogeneous immune responses to viral infection, which may inform future vaccine strategies and public health control.

US state department’s Sarah B Rogers has become face of White House’s hostility to European liberal democracies

Covid-19 is not just a respiratory infection. Cardiovascular symptoms are seen in both acute and long covid. Katharine Lang reports on what we’ve learnt since the onset of the pandemic Cardiovascular complications from covid-19 have been seen widely since the early days of the pandemic, when a small study in Wuhan reported myocardial injury in several patients.1 Soon after, studies found that up to 30% of those admitted to intensive care units showed myocardial injury.23 “In many respects covid-19 is a vascular disease masquerading as a respiratory one,” says Andy Benest, vascular biologist at the University of Nottingham. Although covid is transmitted through the respiratory system, much of the pathology unfolds in the vascular system, with microvascular damage, thromboinflammation, and dysregulated perfusion underpinning the cardiac, pulmonary, and neurological manifestations of severe disease. “The virus enters through the airways but exerts its systemic effects through the vasculature, the common denominator in the lungs, heart, kidneys, and brain,” Benest tells The BMJ . Cardiovascular complications are relatively common in the acute phase of covid. Studies have found that acute cardiac injury occurred in 6-25% of people admitted to hospital with covid.4 One 2020 study reported that 14.1% of people admitted to hospital with covid experienced some type of cardiovascular complication.5 Early studies suggested that the endothelium …

Moderna requests meeting to discuss refusal as decision could have implications for all new and updated vaccines

Moderna requests meeting to discuss refusal as decision could have implications for all new and updated vaccines