Although recent studies have suggested that the Omicron strain is less severe, the prevalence of long Omicron variants and their subvariant waves continues today. Here, we analyze the pathological characteristics of SARS-CoV-2 variants in cynomolgus macaques. Prolonged re-challenge analysis results in the establishment of re-infection in some macaques with both the same strain and different strains. Omicron infection shows low pathogenicity; however, all macaques that developed pneumonia were inoculated with Omicron strains at the second inoculation. Interestingly, antibodies against the Wuhan, Alpha, and Delta strains are strongly induced regardless of the strain, but antibodies against Omicron strains are not. Moreover, despite the re-infection strain, antibody levels against the Wuhan strain are highest, suggesting original antigenic sin. In addition, Omicron infection induces weaker antigen-specific T-cell responses. These results indicate that immune responses to viral infection differ between the variants, and these differences could inform vaccine development strategies. Investigation of SARS-CoV-2 variants using a COVID-19 monkey model reveals heterogeneous immune responses to viral infection, which may inform future vaccine strategies and public health control.

America’s disease surveillance system is broken. Here’s how to replace it.

Keir Starmer to warn tech companies that ‘no platform gets a free pass’ after deepfake scandal involving Grok

The department has sent Google, Meta and other companies hundreds of subpoenas for information on accounts that track or comment on Immigration and Customs Enforcement, officials and tech workers said.

Jon Stewart digs into MAGA's hair-trigger outrage at anything that doesn't align with their narrow set of values, from boycotting Bad Bunny's Super Bowl halftime show with TPUSA's own "English"-language mediocrity fest, to the president setting a new racism high score with a social media post dehuma

Two little‑known animal viruses are worth watching in 2026 and beyond: Influenza D (common in cattle) and a dog coronavirus called CCoV‑HuPn‑2018.

Cases are spreading between children in Enfield as the virus exploits low MMR vaccination rates, medical experts say

America’s disease surveillance system is broken. Here’s how to replace it.

Cases are spreading between children in Enfield as the virus exploits low MMR vaccination rates, medical experts say

Edge - Jeffrey Epstein's favourite intellectual salon - was sold to me as a gathering of the world's finest minds, writes Virginia Heffernan. The files reveal it was something far darker: a decades-lo...

Jon Stewart digs into MAGA's hair-trigger outrage at anything that doesn't align with their narrow set of values, from boycotting Bad Bunny's Super Bowl halftime show with TPUSA's own "English"-language mediocrity fest, to the president setting a new racism high score with a social media post dehuma

Marco Rubio has told European leaders at the Munich Security Conference that the continent 'belongs with' the US, as the two have a 'spiritual' tie. Matt Frei spoke to journalist Lindsey Hilsum, who is in Munich, to find out more. Listen to the full show on the all-new LBC App: https://app.af.lbc.