Thiago Carvalho
@cyrilpedia.bsky.social
I've worked on all of science, from T cells to B cells.
https://fellowsherpa.com
https://fellowsherpa.com
RIP Steve Cropper. Among other things, a member of the Blues Brothers band. Belushi & Aykroyd put together an incredible group of musicians (to be fair, they were on a mission from God).
www.nytimes.com/2025/12/03/a...
www.nytimes.com/2025/12/03/a...
Steve Cropper, Guitarist, Songwriter and Shaper of Memphis Soul Music, Dies at 84
www.nytimes.com
December 8, 2025 at 12:11 AM
RIP Steve Cropper. Among other things, a member of the Blues Brothers band. Belushi & Aykroyd put together an incredible group of musicians (to be fair, they were on a mission from God).
www.nytimes.com/2025/12/03/a...
www.nytimes.com/2025/12/03/a...
Reposted by Thiago Carvalho
This review of the current state of knowledge about the origins or intermediate hosts of pathogens that have historically affected humans is valuable. A couple of comments below. www.nature.com/articles/s41... #histmed #aDNA
Ancient DNA insights into diverse pathogens and their hosts - Nature Reviews Genetics
Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution, zoonotic events and the spread of p...
www.nature.com
December 5, 2025 at 11:03 PM
This review of the current state of knowledge about the origins or intermediate hosts of pathogens that have historically affected humans is valuable. A couple of comments below. www.nature.com/articles/s41... #histmed #aDNA
Reposted by Thiago Carvalho
Films used to employ photographers to make stills from production.
Look at this glorious image of Ingrid Bergman. Look at the tones. The perfectly metered zones of exposure.
Also, damn… They knew how to dress.
Look at this glorious image of Ingrid Bergman. Look at the tones. The perfectly metered zones of exposure.
Also, damn… They knew how to dress.
Ingrid Bergman by Ernest A. Bachrach for Notorious (1946).
December 7, 2025 at 11:41 PM
Films used to employ photographers to make stills from production.
Look at this glorious image of Ingrid Bergman. Look at the tones. The perfectly metered zones of exposure.
Also, damn… They knew how to dress.
Look at this glorious image of Ingrid Bergman. Look at the tones. The perfectly metered zones of exposure.
Also, damn… They knew how to dress.
Reposted by Thiago Carvalho
He is stealing our money, to be clear. This is theft of public resources.
MS NOW, citing three unnamed sources, reports Patel has, at least twice, ordered his girlfriend's FBI security detail to also escort one of her allegedly intoxicated friends after a night of partying. Agents have objected to the order, only for Patel to throw a fit trib.al/Kk54JRb
December 7, 2025 at 11:53 PM
He is stealing our money, to be clear. This is theft of public resources.
Movie you’ve watched more than six times with a gif. Hard mode: no Stars (Wars nor Trek), LOTR, or Marvel, Disney Animated or Pixar
December 7, 2025 at 11:53 PM
Movie you’ve watched more than six times with a gif. Hard mode: no Stars (Wars nor Trek), LOTR, or Marvel, Disney Animated or Pixar
Reposted by Thiago Carvalho
I want to stress here that Tracy Beth Høeg, new head of CDER—seen here being promoted by Children’s Health Defense, the anti-vax group Robert Kennedy Jr. founded—has zero expertise in vaccines.
She is a sports medicine doctor.
She is a sports medicine doctor.
December 7, 2025 at 11:46 PM
I want to stress here that Tracy Beth Høeg, new head of CDER—seen here being promoted by Children’s Health Defense, the anti-vax group Robert Kennedy Jr. founded—has zero expertise in vaccines.
She is a sports medicine doctor.
She is a sports medicine doctor.
Reposted by Thiago Carvalho
É é por isso, amiguinhes, que a gente não pode privatizar serviços básicos como transporte e fornecimento de água e esgoto
December 7, 2025 at 6:18 PM
É é por isso, amiguinhes, que a gente não pode privatizar serviços básicos como transporte e fornecimento de água e esgoto
Reposted by Thiago Carvalho
Kaylan et al. generated mice with genetic deletion of Gpr31b to test the hypothesis that the G protein-coupled receptor GPR31 promotes β-cell and macrophage inflammatory signaling and contributes to β-cell dysfunction in diabetes. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
The G Protein-Coupled Receptor GPR31 Promotes Pro-inflammatory Responses in Pancreatic Islets and Macrophages
In type 1 diabetes (T1D), the innate and adaptive immune systems attack and eventually destroy the insulin-secreting pancreatic β cells. During this process, β cells activate inflammatory signaling pa...
www.biorxiv.org
December 5, 2025 at 9:12 AM
Kaylan et al. generated mice with genetic deletion of Gpr31b to test the hypothesis that the G protein-coupled receptor GPR31 promotes β-cell and macrophage inflammatory signaling and contributes to β-cell dysfunction in diabetes. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
Reposted by Thiago Carvalho
Who has made this 🤣
December 7, 2025 at 1:49 PM
Who has made this 🤣
Reposted by Thiago Carvalho
Such a great collection of papers on #mitochondrialdisease from #week49! 📚 Congratulations to all authors! biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al
@biomednews.bsky.social @mitoscientist.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al
December 7, 2025 at 2:54 PM
Such a great collection of papers on #mitochondrialdisease from #week49! 📚 Congratulations to all authors! biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al
@biomednews.bsky.social @mitoscientist.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al
Reposted by Thiago Carvalho
Are you a researcher in the field of history of science, technology and medicine? The #NotesAndRecords essay award is now open for entries until 28 February 2026. Visit our website find out more: buff.ly/dedMm93 #HistSci #HistSTM
December 7, 2025 at 10:01 AM
Are you a researcher in the field of history of science, technology and medicine? The #NotesAndRecords essay award is now open for entries until 28 February 2026. Visit our website find out more: buff.ly/dedMm93 #HistSci #HistSTM
"The FDA has proposed cutting fees for early-stage companies conducting clinical development in the US instead of abroad.
(...)
The FDA also introduced the idea of companies innovating abroad paying additional yearly fees after submitting an investigational new drug application"
(...)
The FDA also introduced the idea of companies innovating abroad paying additional yearly fees after submitting an investigational new drug application"
FDA floats user fee cuts for early-stage US trials, additional fees for overseas development
The FDA has proposed cutting fees for early-stage companies conducting clinical development in the U.S. instead of abroad. | The FDA has proposed cutting fees for early-stage companies conducting clin...
www.fiercebiotech.com
December 7, 2025 at 1:39 PM
"The FDA has proposed cutting fees for early-stage companies conducting clinical development in the US instead of abroad.
(...)
The FDA also introduced the idea of companies innovating abroad paying additional yearly fees after submitting an investigational new drug application"
(...)
The FDA also introduced the idea of companies innovating abroad paying additional yearly fees after submitting an investigational new drug application"
'Now, a report by Gustafsson et al. in Nature Biotechnology has identified a subset of thymic mesenchymal cells (ThyMCs) that drives thymic regeneration and harnessed these cells to restore immune function in mice after hematopoietic stem cell transplantation.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mesenchymal cells rebuild the thymus - Nature Biotechnology
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.
www.nature.com
December 7, 2025 at 1:26 PM
'Now, a report by Gustafsson et al. in Nature Biotechnology has identified a subset of thymic mesenchymal cells (ThyMCs) that drives thymic regeneration and harnessed these cells to restore immune function in mice after hematopoietic stem cell transplantation.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Thiago Carvalho
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
www.nature.com
December 7, 2025 at 3:18 AM
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"São dezenas. Dormem à porta, agasalham-se como podem, à chuva, ao frio, na esperança de amanhecer e ainda lhes calhar uma das senhas de atendimento do dia."
www.publico.pt/2025/12/05/s...
www.publico.pt/2025/12/05/s...
“Não posso sair do país, não posso entrar no meu. Estou preso.” Dormir à porta da AIMA tornou-se uma rotina
Atrasos na renovação de autorização de residência estão a deixar imigrantes no limbo. À porta da AIMA, de onde as filas nunca desapareceram, a espera sem fim esconde histórias de vidas interrompidas.
www.publico.pt
December 7, 2025 at 1:23 PM
"São dezenas. Dormem à porta, agasalham-se como podem, à chuva, ao frio, na esperança de amanhecer e ainda lhes calhar uma das senhas de atendimento do dia."
www.publico.pt/2025/12/05/s...
www.publico.pt/2025/12/05/s...
Reposted by Thiago Carvalho
I am ratcheting down my social media, but let me just say that all European leaders except on the far Right should note that the U.S. now seeks regime change in their country; basically seeks to depose them. US strategy is to support the political forces that threaten liberal democracy in Europe.
Trump Administration Says Europe Faces ‘Civilizational Erasure’
www.nytimes.com
December 6, 2025 at 7:29 AM
I am ratcheting down my social media, but let me just say that all European leaders except on the far Right should note that the U.S. now seeks regime change in their country; basically seeks to depose them. US strategy is to support the political forces that threaten liberal democracy in Europe.
Reposted by Thiago Carvalho
"(...) sete anos após a sua criação, a UKRI não alcançou plenamente esses objetivos. A simples agregação administrativa não foi suficiente para gerar ganhos significativos de eficiência nem sinergias generalizadas entre as agendas de investigação e inovação."
Governança da ciência: o que Portugal pode aprender com a experiência britânica
O Governo português identificou o caso britânico como uma das inspirações para esta reforma. No entanto, a análise aprofundada de avaliações independentes revela uma realidade menos otimista.
www.publico.pt
November 29, 2025 at 9:44 AM
"(...) sete anos após a sua criação, a UKRI não alcançou plenamente esses objetivos. A simples agregação administrativa não foi suficiente para gerar ganhos significativos de eficiência nem sinergias generalizadas entre as agendas de investigação e inovação."
Reposted by Thiago Carvalho
Tools
"Here, we present an expansive collection of molecular genetic strategies to label a range of transcriptionally distinct enteric neuron subpopulations, as well as orthogonal approaches capable of genetically isolating extrinsic sensory and sympathetic neuron populations."
#Immunology
"Here, we present an expansive collection of molecular genetic strategies to label a range of transcriptionally distinct enteric neuron subpopulations, as well as orthogonal approaches capable of genetically isolating extrinsic sensory and sympathetic neuron populations."
#Immunology
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 30, 2025 at 3:01 PM
Tools
"Here, we present an expansive collection of molecular genetic strategies to label a range of transcriptionally distinct enteric neuron subpopulations, as well as orthogonal approaches capable of genetically isolating extrinsic sensory and sympathetic neuron populations."
#Immunology
"Here, we present an expansive collection of molecular genetic strategies to label a range of transcriptionally distinct enteric neuron subpopulations, as well as orthogonal approaches capable of genetically isolating extrinsic sensory and sympathetic neuron populations."
#Immunology
Reposted by Thiago Carvalho
“This country has in the last 10 years moved from 3rd gear to 5th gear & is going full speed. I still hear in the news ‘the Chinese are coming with their cheap cars flooding the European market’. I’m telling you, come here, look at these ‘cheap cars’. They are full of tech. Their quality is so good"
Is China winning the innovation race?
Once the world’s factory, Beijing’s relentless focus on R&D means the country has become the world’s laboratory
www.ft.com
November 30, 2025 at 4:30 PM
“This country has in the last 10 years moved from 3rd gear to 5th gear & is going full speed. I still hear in the news ‘the Chinese are coming with their cheap cars flooding the European market’. I’m telling you, come here, look at these ‘cheap cars’. They are full of tech. Their quality is so good"
Reposted by Thiago Carvalho
“So, to recap here,” Porter said. “The drug didn’t get any better. The cancer patients didn’t get any better. You just got better at making money. You just refined your skills at price gouging.”
www.propublica.org/article/revl...
www.propublica.org/article/revl...
The Price of Remission: This Cancer Drug Saves Lives — but Costs a Fortune. I Wanted to Know Why.
When I was diagnosed with cancer, I set out to understand why a single pill of Revlimid cost the same as a new iPhone. I’ve covered high drug prices as a reporter for years. What I discovered shocked ...
www.propublica.org
November 30, 2025 at 6:08 PM
“So, to recap here,” Porter said. “The drug didn’t get any better. The cancer patients didn’t get any better. You just got better at making money. You just refined your skills at price gouging.”
www.propublica.org/article/revl...
www.propublica.org/article/revl...
Reposted by Thiago Carvalho
'Professor Sir Mike Richards, chair of the screening committee, said he concluded that checking all men over 50 regularly “may lead to a small reduction in prostate cancer deaths”, but the harms outweighed the benefits because of “very high levels of overdiagnosis”.'
www.ft.com/content/9065...
www.ft.com/content/9065...
Routine prostate screening rejected by NHS advisers
Committee recommends limited programme for thousands of men with mutations in BRCA1 or BRCA2 genes
www.ft.com
December 1, 2025 at 8:43 AM
'Professor Sir Mike Richards, chair of the screening committee, said he concluded that checking all men over 50 regularly “may lead to a small reduction in prostate cancer deaths”, but the harms outweighed the benefits because of “very high levels of overdiagnosis”.'
www.ft.com/content/9065...
www.ft.com/content/9065...
Reposted by Thiago Carvalho
'You kind of want to know your chances before trying for something. It’s a big difference realizing that you have a 10% chance of being successful versus a 4% chance. The latter might motivate you to try something else like buying a lottery ticket or selling photos of your feet.'
New NIH Process To Choose Grant Awardees Will No Longer Use Paylines
The National Institutes of Health has just announced that it will no longer rely on paylines to determine who gets NIH grant funding. Here's what this change might do.
www.forbes.com
December 1, 2025 at 8:53 AM
'You kind of want to know your chances before trying for something. It’s a big difference realizing that you have a 10% chance of being successful versus a 4% chance. The latter might motivate you to try something else like buying a lottery ticket or selling photos of your feet.'
Reposted by Thiago Carvalho
Tudo "& then some"
'Stoppard tinha tudo. Escrevia muito bem e escrevia muito. Era giro e alto e elegante. Estava sempre a ler. Amou e foi amado, teve grandes amigos, pequenos amigos, colegas formidáveis e a companhia, sempre que lhe apetecia, de grandes cabeças e de outras pessoas muito divertidas.'
'Stoppard tinha tudo. Escrevia muito bem e escrevia muito. Era giro e alto e elegante. Estava sempre a ler. Amou e foi amado, teve grandes amigos, pequenos amigos, colegas formidáveis e a companhia, sempre que lhe apetecia, de grandes cabeças e de outras pessoas muito divertidas.'
Obrigado, Tom Stoppard
Stoppard tinha tudo. Escrevia muito bem e escrevia muito. Era giro e alto e elegante. Estava sempre a ler. Amou e foi amado, teve grandes amigos, pequenos amigos e colegas formidáveis.
www.publico.pt
December 1, 2025 at 8:57 AM
Tudo "& then some"
'Stoppard tinha tudo. Escrevia muito bem e escrevia muito. Era giro e alto e elegante. Estava sempre a ler. Amou e foi amado, teve grandes amigos, pequenos amigos, colegas formidáveis e a companhia, sempre que lhe apetecia, de grandes cabeças e de outras pessoas muito divertidas.'
'Stoppard tinha tudo. Escrevia muito bem e escrevia muito. Era giro e alto e elegante. Estava sempre a ler. Amou e foi amado, teve grandes amigos, pequenos amigos, colegas formidáveis e a companhia, sempre que lhe apetecia, de grandes cabeças e de outras pessoas muito divertidas.'
Reposted by Thiago Carvalho
“I definitely think about my family when we organize, when we go out on patrols, because that could have been my family in prison,” said Ms. Oba, 33. “It’s just a difference of what, like, 80 years?”
www.nytimes.com/2025/11/30/u...
www.nytimes.com/2025/11/30/u...
Haunted by History, Japanese Americans Fight Trump’s Immigration Crackdown
www.nytimes.com
December 1, 2025 at 9:31 AM
“I definitely think about my family when we organize, when we go out on patrols, because that could have been my family in prison,” said Ms. Oba, 33. “It’s just a difference of what, like, 80 years?”
www.nytimes.com/2025/11/30/u...
www.nytimes.com/2025/11/30/u...