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PAIN

@painthejournal.bsky.social

310 followers 100 following 240 posts

PAIN is the official publication of the International Association for the Study of Pain (IASP). PAIN publishes original research on pain and provides a multidisciplinary forum for the dissemination of basic and applied pain research.

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PAIN @painthejournal.bsky.social · 19h

October’s #PAIN cover art is from Isler et al.’s new study. They find that spinal microglia become reactive and trigger hypersensitivity in response to combined optogenetic activation of nociceptive and nonnociceptive fibers. Learn more in #PAIN bit.ly/4nssUHO

PAIN @painthejournal.bsky.social · 1d

New article by Sparber et al. represents the largest investigation of splicing variants in the SCN9A gene in patients with congenital insensitivity to pain. Learn more in #PAIN bit.ly/42Ftx8g

PAIN @painthejournal.bsky.social · 2d

Murphy et al.’s review finds that mechanism-based, QST methodologies do not consistently predict pain or disability on an individual level in hip or knee osteoarthritis. Learn more in #PAIN bit.ly/42FtwBe

PAIN @painthejournal.bsky.social · 3d

The October 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/3YGaclU

PAIN @painthejournal.bsky.social · 3d

Zheng et al. find that cGMP-dependent protein kinase I in the dorsal hippocampus is a key determinant for chronic pain and pain-related cognitive deficit. Learn more in #PAIN bit.ly/4gFAqwh

PAIN @painthejournal.bsky.social · 6d

Counting the days to @IASPpain’s World Congress on Pain 2026 in Bangkok? Make the wait easier by revisiting #PAIN’s collection of articles from the 2024 plenary speakers bit.ly/3K7OuT6

PAIN @painthejournal.bsky.social · 6d

In this week’s #PAIN Featured Image, Ridehalgh et al. analyze T2 weighted images of the brachial plexus, dorsal root ganglia, and median nerve at the wrist. Learn more at bit.ly/4nnyQSj

PAIN @painthejournal.bsky.social · 8d

Billens et al. find little consistent link between genetic/epigenetic variants and altered pain modulation in CMP. Dynamic pain measures appear robust, but more reproducible research is needed. Learn more in #PAIN bit.ly/4nhEgxT

PAIN @painthejournal.bsky.social · 9d

Wei et al. find an increased risk of opioid use disorder and opioid overdose among older adults who experienced uncontrolled and high-impact pain after prescription opioid therapy. Learn more in #PAIN bit.ly/3HnqBWs

PAIN @painthejournal.bsky.social · 10d

The October 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/3YGaclU

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PAIN @painthejournal.bsky.social · 10d

Jones et al.’s exploratory region-of-interest approach revealed widespread associations between limitations in normal activities due to pain and white matter microstructure in male but not female youth. Learn more in #PAIN bit.ly/3HnqAlm

PAIN @painthejournal.bsky.social · 13d

This week’s #PAIN Featured Images are from the 4th and final entry in our essay series on the past Editors-in-Chief of PAIN. Learn more about Frank Keefe’s fascinating life and career in Williams et al. bit.ly/4ntoMHz

PAIN @painthejournal.bsky.social · 14d

Karoam et al. find that lesions associated with central poststroke pain localize to a nociceptive pathway to a greater extent than lesions that are not associated with pain. Learn more in #PAIN bit.ly/3HnqE4A

PAIN @painthejournal.bsky.social · 15d

Todd et al. find emerging evidence that interpretation biases are a treatment target that can be modified for improved pain outcomes. Learn more in #PAIN bit.ly/4lhSBJa

PAIN @painthejournal.bsky.social · 16d

Taylor et al. assert that racialized, gendered, and rank-based inequities in low back pain follow-up visit and administrative action receipt in active duty service members require mitigation. Learn more in #PAIN bit.ly/3HnqzOk

PAIN @painthejournal.bsky.social · 17d

Counting the days to @iasp.bsky.social’s World Congress on Pain 2026 in Bangkok? Make the wait easier by revisiting #PAIN’s collection of articles from the 2024 plenary speakers bit.ly/3K7OuT6 #PainAwarenessMonth

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PAIN @painthejournal.bsky.social · 17d

The forebrain circuits that regulate pain modulatory circuits during hyperalgesia are unknown. Crawford et al. identify forebrain activity and forebrain-brainstem connectivity that underpins nocebo hyperalgesia. Learn more in #PAIN bit.ly/46MK8Ki

PAIN @painthejournal.bsky.social · 20d

This week’s #PAIN Featured Image comes from Suñol et al.’s study of resilience in juvenile fibromyalgia. Clusters represent global connectivity increases in the JFM subgroup; psych term associations visualized via wordcloud. Learn more in #PAIN bit.ly/46FWeF4

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PAIN @painthejournal.bsky.social · 21d

Early career researchers: does the prospect of peer review feel daunting? Check out this free webinar from #PAIN EiC @karenddavis.bsky.social and #PAINReports EiC David Yarnitsky bit.ly/4nl5pzK #PainAwarenessMonth

PAIN @painthejournal.bsky.social · 21d

Ryu et al. find that invasive neural recordings of patients with chronic pain revealed that higher pain levels were associated with increased regularity in spike-like events within the 4- to 15-Hz band. Learn more in #PAIN bit.ly/46HTsPH

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PAIN @painthejournal.bsky.social · 22d

Palermo et al. find that parent distress moderated the effects of digital cognitive-behavioral therapy on adolescent sickle cell disease pain. Learn more in #PAIN bit.ly/45jrTK1

PAIN @painthejournal.bsky.social · 23d

This #PainAwarenessMonth, we’d like to highlight an excellent resource for early career researchers: How to Peer Review Pain Research webinar by #PAIN EiC @karenddavis.bsky.social and #PAINReports EiC David Yarnitsky bit.ly/4nl5pzK

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PAIN @painthejournal.bsky.social · 23d

Bergeria et al. find that cannabidiol enhances acute hydromorphone analgesic effects. When hydromorphone was combined with higher doses of cannabidiol, more adverse effects and participant-rated Bad Effects were observed. Learn more in #PAIN bit.ly/45n7Jit

PAIN @painthejournal.bsky.social · 24d

#PAIN is proud to highlight work from early career researchers. If you have questions about publishing in the top journal devoted to pain research, we’d love to hear from you! #PainAwarenessMonth

PAIN @painthejournal.bsky.social · 24d

Alayoubi et al. find that myrcene, a terpene found in cannabis, dose-dependently attenuated allodynia associated with nerve injury by engaging CB1 receptors without producing negative reinforcement or direct activation of CB1 receptors. Learn more in #PAIN bit.ly/3HnqzxO