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Reposted by Aubin Moutal

Migraine Science Collaborative (MSC) @migrainecollab.bsky.social · 1d

MSC News: A US population-based analysis shows significant increases in chronic pain prevalence, and of high-impact chronic pain, after the pandemic. The upsurges were apparent for almost all pain sites considered in the study, including head/migraine pain.

migrainecollaborative.org/chronic-pain...

Chronic Pain Prevalence after the COVID-19 Pandemic: Troubling Findings - Migraine Science Collaborative

A new US population-based analysis shows significant increases in the prevalence of chronic pain, and of high-impact chronic pain, in the wake of the pandemic. The upsurges were apparent for almost al...

migrainecollaborative.org

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Ardem Patapoutian @ardemp.bskyverified.social · 1d

Attending #SfN2025 in San Diego☀️? Don’t miss the Dorris Neuroscience Center Symposium at @scripps.edu, happening right before the meeting. A great lineup of speakers to kick off your SfN week. Plan your trip accordingly and register for free here:
www.eventbrite.com/e/dorris-neu...

Please amplify!

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Christophe 🔬 L @christlet.bsky.social · 21d

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

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Kate Sadler @katesadlerphd.bsky.social · 22d

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

www.cell.com

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Ted Price @tedpricethepainguy.bsky.social · 25d

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

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Ted Price @tedpricethepainguy.bsky.social · Sep 3

Well, well, well: www.nature.com/articles/s41...

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol - Neuropsychopharmacology

Neuropsychopharmacology - Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol

www.nature.com

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Michalis Averof @michalis-averof.bsky.social · Sep 2

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

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Alles Lab @alleslab.bsky.social · Aug 28

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

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Aubin Moutal @aubinmoutal.bsky.social · Aug 28

That's awesome Congrats Sascha and Bryan !

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Ted Price @tedpricethepainguy.bsky.social · Aug 24

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

mheming.bsky.social @mheming.bsky.social · Aug 24

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

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mheming.bsky.social @mheming.bsky.social · Aug 24

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

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Diana Tavares Ferreira @dianatavf.bsky.social · Aug 19

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy

www.jci.org

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Aubin Moutal @aubinmoutal.bsky.social · Aug 18

CRMP2 expression and function is already validated in human lymphocytes from patients with HTLV1 and MS. Which brings a lot of translational relevance to this manuscript. It's all very exciting
academic.oup.com/jimmunol/art...
academic.oup.com/jimmunol/art...

Aubin Moutal @aubinmoutal.bsky.social · Aug 18

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

PAIN @painthejournal.bsky.social · Aug 18

Jiang et al. find that collapsin response mediator protein 2 phosphorylation in CD4+ T cells affects spinal infiltration and pain modulation, hinting at novel therapies for rheumatoid arthritis–related chronic pain. Learn more in #PAIN bit.ly/3HnqDO4

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Scheff Research Lab @schefflab.bsky.social · Aug 8

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...

Rethinking relief: Targeting sensory neurons to combat cancer and pain

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiolo...

www.cell.com

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

Buy the dip! 😂

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

We started with an observation from the clinic but ended with a model, a mechanism, and a path toward treatment.

Science is at its best when it closes the loop—from bench to bedside, and back again.

We’re proud of what this work uncovered—but even more excited about what it unlocks next!

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

I am grateful to all co-authors for their input and support.

This project was supported by funds from NINDS, The University of Arizona and Saint Louis University. Thanks to our funders for supporting high-risk, translational work.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

Lyuba Salih & Nicolas Dumaire at SLU took time off from their graduate projects to help close key experiments.

Jérôme Honnorat provided invaluable clinical insight and precious patient sera.

This project began with Rajesh Khanna, whose mentorship and support made the finish line possible.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

This was a true team effort:

Laurent Martin and Harrison Stratton contributed greatly with behavior, electrphysiology, critical discussions and key ideas that helped to transform dream experiments into figures.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

This project took us beyond our scientific comfort zone and into a highly translational adventure.
We worked with human samples and ran studies designed to directly inform patient care. In doing so, we built a framework to rapidly uncover how CRMP5 autoantibodies cause pain—and how to stop it.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

We then created a DNA immunization model that replicated CRMP5 autoimmunity and pain in rats.

this led us to:
- Evaluate the therapeutic potential of clinically available pain relieving drugs
- Use anti-CD20 (Rituximab, B cell depletion) to reverse behavior and hyperexcitability long term.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

We show that patient-derived anti-CRMP5 autoantibodies:
🔹 Penetrate DRG neurons and bind intracellular CRMP5
🔹 Induce hyperexcitability in DRG neurons
🔹 Cause mechanical hypersensitivity in rats

Depleting antibodies or masking their epitopes blocks these effects.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

Pain is a frequent yet poorly understood symptom in paraneoplastic neurological syndromes. We started from clinical reports of ~80% of patients with anti-CV2/CRMP5 autoantibodies having a painful neuropathy, but the mechanisms remained unknown.

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Aubin Moutal @aubinmoutal.bsky.social · Aug 8

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41...
This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes.
#PainResearch

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

www.nature.com

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