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Monty Montano @montyma.bsky.social · Aug 29

Great conversation with Erica Sloan about stress and cancer…https://m.youtube.com/watch?v=5zJzPdzE65g

Episode 1: A Conversation with Dr. Erica Sloan

YouTube video by Advanced Portfolio News

m.youtube.com

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 20d

Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer https://www.biorxiv.org/content/10.1101/2025.09.19.677339v1

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Scheff Research Lab @schefflab.bsky.social · 16d

The NOA has landed! We have our first 🛏️to 🔬 to🛌translation! In collaboration with Glycyx Therapeutics, we received funding for a multi-institutional clinical trial to test if peripheral acting OPRM1 antagonism can improve response to immune checkpoint blockade in head and neck cancer patients!

Here is the work that got us to this point: https://jitc.bmj.com/content/12/11/e009962

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Scheff Research Lab @schefflab.bsky.social · 17d

Congratulations to @andremartel.bsky.social for his first author preprint, now available on bioRxiv: Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer! #cancerneuroscience #cancerpain
www.biorxiv.org/content/10.1...

Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer

Oral squamous cell carcinoma (OSCC) is one of the most painful cancers, with patients frequently reporting spontaneous, neuropathic-like pain. While sympathetic and sensory nerves have been individual...

www.biorxiv.org

Scheff Research Lab @schefflab.bsky.social · Sep 3

📢Happy to announce the Scheff lab's contribution to this important exploration of #neurobiology of #cancer, out now in @cp-neuron.bsky.social! Thanks to @andremartel.bsky.social!

Neuron @cp-neuron.bsky.social · Sep 3

A Review by Alexander Birbrair and colleagues on the role of sensory neurons within the tumor microenvironment
www.cell.com/neuron/fullt...

Entangled cellular and molecular relationships at the sensory neuron-cancer interface

Beyond acting as a passive route for nociceptive signals, sensory neurons are active participants in tumor progression. This review examines sensory neuron-tumor bidirectional interaction and explores...

www.cell.com

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Scheff Research Lab @schefflab.bsky.social · Aug 19

Learn more about the series, and see other beautiful poster images here:
pcpr.pitt.edu/seminar-seri...

PCPR Seminars – Pittsburgh Center for Pain Research

pcpr.pitt.edu

Scheff Research Lab @schefflab.bsky.social · Aug 19

The Scheff Lab image was selected to be the background of the @pcpr-pittpain.bsky.social seminar series poster highlighting mammary innervating dorsal root ganglia neurons. This image was taken in a study understanding the impact of sensory neurons on breast cancer progression and (lack of) pain.

Dorsal root ganglia neurons stained with green, blue, and pink dyes.

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Scheff Research Lab @schefflab.bsky.social · Aug 13

Additional link here: authors.elsevier.com/a/1lZPG5TA51...

authors.elsevier.com

Scheff Research Lab @schefflab.bsky.social · Aug 8

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...

Rethinking relief: Targeting sensory neurons to combat cancer and pain

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiolo...

www.cell.com

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Ted Price @tedpricethepainguy.bsky.social · Jun 25

www.biorxiv.org/content/10.1... New data from us on Botox-A effects on human DRG neurons, including some really surprising effects on DRG transcriptome. All of this work was led by Katherin Gabriel, and was a great collaboration with our friends at AbbVie.

Botulinum Neurotoxin A1 Signaling in Pain Modulation within Human Sensory Neurons

Botulinum neurotoxin type A1 (BoNT/A1) is an effective treatment for chronic migraine, but its direct mechanism of action on human sensory neurons has not been fully elucidated. While rodent studies o...

www.biorxiv.org

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Nature Reviews Cancer @natrevcancer.nature.com · Jun 23

#REVIEW 🚨
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️

Neuro-immune cross-talk in cancer - Nature Reviews Cancer

The nervous and immune systems have co-evolved to respond to threats, including cancer. In this Review, Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.

www.nature.com

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Scheff Research Lab @schefflab.bsky.social · May 21

Thank to #RushtoCrush for a great weekend raising funds for #cancer #research!

Scheff Research Lab @schefflab.bsky.social · May 9

Thanks to @pcpr-pittpain.bsky.social and other sponsors for this event!
painday.pitt.edu

Home | Pain Day 2025

painday.pitt.edu

Scheff Research Lab @schefflab.bsky.social · May 8

🎉Congratulations to @andremartel.bsky.social for winning BEST POSTER at yesterday's #painday, held at the University of Pittsburgh @cnup.bsky.social! Thanks to Hannah and @nehamokhasi.bsky.social for their excellent contributions.

Graduate student Andre Martel Matos stands next to his poster entitled: Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain.

Hannah White presents her poster entitled: Sensory Innervation in the Tumor Microenvironment of Breast Cancer.

Certificate awarding Andre Martel Matos with Best Poster Presentation in Pre-Clinical Research (predoctoral) category.

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Scheff Research Lab @schefflab.bsky.social · May 6

Thanks to @usasp.bsky.social for a great conference! Dr Scheff discussed reverse translation in #cancerpain and presented a poster detailing new work on radiation-induced pain and oral mucositis. @andremartel.bsky.social presented updates on his project on sympathetics and cancer pain. #research

Graduate student Andre Martel Matos presents his poster entitled "Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain" to several conference attendees

Dr Nicole Scheff presents research poster entitled "Temporal characterization of radiation-induced oral pain using a mouse model" to two conference attendees

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Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · Apr 1

mbi.ufl.edu/2025/04/01/r...

Researchers present latest advances in developing nonopioid pain relievers » McKnight Brain Institute » University of Florida

UF Center for Advanced Pain Therapeutics and Research (CAPToR) hosts inaugural symposium.

mbi.ufl.edu

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Scheff Research Lab @schefflab.bsky.social · Mar 7

@andremartel.bsky.social and I had an awesome time teaching at the inaugural Cold Spring Harbor Laboratory 2025 Methods in Cancer Neuroscience course this week! #cshl #cancerneuroscience. Wish we could have stayed but had to be home for the Stand Up For Science Event! @standupforscience.bsky.social

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US Association for the Study of Pain @usasp.bsky.social · Feb 10

The Gulf Coast Consortia invites you to register for their Feb. 21, #Pain2025 workshop featuring Rita Allen Scholars, Kara Marshall, Baylor College of Medicine, and Katelyn Sadler, Univ. of Texas, Dallas. The event will occur via Zoom webinar on Feb. 21, from 1-2 pm (CST).

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Alles Lab @alleslab.bsky.social · Dec 17

Elegant paper from the Gereau lab examining intrinsic adaptive plasticity in mouse and human sensory neurons rupress.org/jgp/article/...

Intrinsic adaptive plasticity in mouse and human sensory neurons | Journal of General Physiology | Rockefeller University Press

In this study, McIlvried, Del Rosario, and colleagues show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sust

rupress.org

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Scheff Research Lab @schefflab.bsky.social · Jan 30

📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...

#neurobiology

Proposed cycle between nociceptive input and autonomic output in cancer. Sensitization of nociceptive sensory neurons by the tumor microenvironment leads to propagation of orthodromic signaling towards the central nervous system (CNS).

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Scheff Research Lab @schefflab.bsky.social · Jan 3

🎉Excited to share that our application, “Breast Cancer Control of Neural Invasion Modulates Immunosurveillance” has been funded by The Magee Women’s Cancer Research and Education Funding Committee. We are grateful for the support to explore this new direction!
#breastcancer #neuroscience #immunology

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Science News @scinews.bsky.social · Dec 5

What is the best time of the month to treat breast cancer? #Nature

"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"

Open Access
www.nature.com/articles/s41...

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Scheff Research Lab @schefflab.bsky.social · Dec 6

inside.upmc.com/opioids-inte...

Opioids Interfere with Cancer Immunotherapy but These Drugs Could Help - UPMC & Pitt Health Sciences News Blog

Opioids are often first-line treatments for cancer-related pain, but they… Read more

inside.upmc.com

Scheff Research Lab @schefflab.bsky.social · Nov 21

📢Check out our new publication, Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma, out now in the Journal for ImmunoTherapy of Cancer! This article presents urgent work with implications for improving ICI therapy responses. jitc.bmj.com/content/12/1...

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Ece Eksi, PhD @eksiece.bsky.social · Nov 13

The application deadline is on December 6th: meetings.cshl.edu/courses.aspx...

Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!

#cancerneuroscience

Methods in Cancer Neuroscience

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

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