The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Also huge props to @allanhpool.bsky.social
and his lab at UTSW for helping optimise our single nuc prep and looking for species differences between human and mice.
This paper builds on the foundation already set and increases our understanding of human spinal cord at an even higher resolution.

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social

www.biorxiv.org/content/10.1...

Apparently bluesky doesn’t like gifs, so check out the supplemental figures for some lovely synapses in space!

Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. I’ll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience!
@tedpricethepainguy.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Highly, highly recommend working with Andy and the Spinal Cord Group!

Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry https://www.biorxiv.org/content/10.1101/2025.04.07.647666v1

Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...