Lightnews — Scholar-powered news

Aleyah E. Goins @goinsyeah.bsky.social · 20h

small typo: type 1 IFN* not y :)

Aleyah E. Goins @goinsyeah.bsky.social · 2d

When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - PubMed

Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types<sup>1</sup>, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into...

pubmed.ncbi.nlm.nih.gov

2 2 4

Aleyah E. Goins @goinsyeah.bsky.social · 2d

This work was done at the #NYU #PainResearchCenter.

Aleyah E. Goins @goinsyeah.bsky.social · 2d

Novel perineural invasion (PNI) mouse model mimics the intractable pain of head & neck cancer in humans 🤯, revealing that cancer-related nerve damage shares features with neurodegeneration. 🧠 Crucial tool for testing future pain treatments! 📈 #NYU #PainResearch #PNI #HNSCC

Perineural Invasion Exhibits Traits of Neurodegeneration - PubMed

Perineural invasion (PNI) frequently occurs in head and neck squamous cell carcinoma (HNSCC), which correlates with poor survival and induces intractable pain and numbness. There is no effective treat...

pubmed.ncbi.nlm.nih.gov

1 1

Reposted by Aleyah E. Goins

Nesia Zurek, PhD @docnessmonster.bsky.social · Aug 29

A blood test for pain?

New work in Nature identifies circulating biomarkers that distinguish chronic pain states—offering a path toward objective, biologically grounded diagnostics.

#PainResearch #Neuroskyence #Biomarkers #ScienceWatch #SciComm #ScienceInTranslation #ChronicPain

Next-generation precision medicine for pain - Molecular Psychiatry

Molecular Psychiatry - Next-generation precision medicine for pain

www.nature.com

4 6 26

Reposted by Aleyah E. Goins

NYU Pain Research Center @nyupainresearch.bsky.social · Aug 29

Incredible! A new imaging system has allowed researchers to map the entire adult mouse peripheral nervous system at micrometer resolution. This is a massive leap in understanding cellular interactions in health and disease. #Neuroscience www.sciencedirect.com/science/arti...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has re…

www.sciencedirect.com

1 2

Reposted by Aleyah E. Goins

Alles Lab @alleslab.bsky.social · Aug 26

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

2 2

Aleyah E. Goins @goinsyeah.bsky.social · Aug 12

pubmed.ncbi.nlm.nih.gov/40699432/
#PainResearch #NeuroSkyence #Neuron #Neuroscience
Inhibiting mRNA quality control in nociceptors reveals pathways driving chronic pain. Must read!

Inhibition of Nonsense-Mediated Decay in Dorsal Root Ganglion Neurons - PubMed

Given the unique morphology of neurons with extensive projections, such as nociceptors, mRNA regulation is crucial for their physiological processes and function. Tools for manipulating post-transcrip...

pubmed.ncbi.nlm.nih.gov

6

Reposted by Aleyah E. Goins

Stephanie Noble @sneuroble.bsky.social · Aug 11

Grant list for general #ECR postdocs and faculty, with additional dedicated lists for #neuroscience / #neuroskyence and #cancer / #oncology

A huge thank you to @deniswirtz.bsky.social & team for this collection

Denis Wirtz @deniswirtz.bsky.social · Aug 11

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

3 11

Reposted by Aleyah E. Goins

UNR Biology Buzz @unr-biologybuzz.bsky.social · Aug 11

We are hiring! Tenure-track position in Neurobiology in the Department of Biology at the University of Nevada, Reno @unevadareno.bsky.social. 🧪🧠 #neuroscience #neuroskyence

jobs.sciencecareers.org/job/674336/a...

Assistant Professor, Neurobiology - Reno, Nevada (US) job with University of Nevada, Reno - College of Science | 674336

The Department of Biology at the University of Nevada, Reno, is looking for a tenure-track assistant professor to join us starting July 1, 2026. We...

jobs.sciencecareers.org

8 8

Aleyah E. Goins @goinsyeah.bsky.social · Aug 11

Lately, I've pivoted to reading scientific literature and not books. I'm sad my book review posts have slowed down because of this. So I'm going to post my to-be-read book list before 2026 instead... #BookSky #ScienceLiterature #NonFiction

Poster with white background and four pastel-colored rounded boxes listing books in order: 1) Breaking Through by Katalin Karikó, 2) The Emperor of All Maladies by Siddhartha Mukherjee, 3) The Omnivore’s Dilemma by Michael Pollan, 4) The Dispossessed by Ursula K. Le Guin.

6

Reposted by Aleyah E. Goins

kittycholamine.bsky.social @kittycholamine.bsky.social · Aug 11

🧪 Philadelphia area Neuroscientists: This is a great opportunity to meet other area neuroscientists and share your work as a speaker (postdoctoral fellow) or with a poster (anyone with data!) www.spinephilly.org #neuroscience #Philadelphia #neuroskyence 🧠

1 3

Aleyah E. Goins @goinsyeah.bsky.social · Aug 9

One of the Astronauts from the golden era 🧑‍🚀 passing is news that stirs up the calling to reach above and beyond. Honored to have been alive at the same time as these talented individuals. 🙌

NASA Echo @nasa-echo.bsky.social · Aug 8

We are saddened by the passing of Jim Lovell, commander of Apollo 13 and a four-time spaceflight veteran.

Lovell's life and work inspired millions. His courage under pressure helped forge our path to the Moon and beyond—a journey that continues today. https://go.nasa.gov/41tbrpq

Astronaut Jim Lovell, wearing a white spacesuit with no helmet, stands outside with a tall rocket and launch tower behind his left shoulder. Lovell is pictured from the chest up; he is looking at the camera and smiling. Credit: NASA

Aleyah E. Goins @goinsyeah.bsky.social · Aug 9

Like my mama always said “nothing is as it seems”, “it could be better than you think” 🤔 🌈
The meditation tonight is to sit deep in anxiety, look around the room and observe the chaos inside, it could be the most insightful and fruitful experience yet. 😘 #BlueSky #HOPE #Hallelujah

1

Aleyah E. Goins @goinsyeah.bsky.social · Aug 5

20 minute walks. 🦋👩‍🍳💋

1

Reposted by Aleyah E. Goins

Alles Lab @alleslab.bsky.social · Jul 31

Thanks for the highlight of our recent work! #PainResearch @painresforum.bsky.social
painresearchforum.org/paper/expres...

EXPRESS: Gabapentin's effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles - Pain Research Forum

Source: Molecular pain Authors: Jenna B Demeter, Nesia A Zurek, Maddy R Koch, Aleyah E Goins, Cristian O Holguin, Mark W Shilling, Michael S Davis, Reza Ehsanian, Sascha Ra Alles, June Bryan de la Peñ...

painresearchforum.org

1 4

Aleyah E. Goins @goinsyeah.bsky.social · Jul 28

This review has been bothering me. Organ innervation leads to pain modulation depending if sympathetic or parasympathetic systems are activated which downstream affects tumor growth?! Rest and digest, rest and digest, rest and digest… #pain #cancer #neuroscience www.nature.com/articles/s41...

Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications

www.nature.com

1

Aleyah E. Goins @goinsyeah.bsky.social · Jul 28

#TourDeFrance ended today and it was a wild ride! #Tadej won the triple crown better than Secretariat, despite stages planned to exploit his weaknesses. Well that’s just a rumor but still goes to show you he won against all odds! #Victory #Pogacar #Cycling

1 1

Aleyah E. Goins @goinsyeah.bsky.social · Jul 21

#BookSky #Space #Exploration #MichaelCollins #CarryingTheFire #Inspirational

2

Aleyah E. Goins @goinsyeah.bsky.social · Jul 18

Summer 2025✨, I read Carrying the Fire by Michael Collins. Favorite book this year. Have you ever wondered about the third guy on Apollo 11? Did you know there was a third guy? I learned so much about space and organizational leadership from down-to-earth descriptions. So easy to consume ravenously!

The cover of Carrying the Fire: An Astronaut’s Journeys by Michael Collins shows a vivid, cloudless blue sky as the background. At the top, the title is centered in large white uppercase letters: CARRYING THE FIRE. Beneath that, in a smaller yellow or white font, it reads An Astronaut’s Journeys. At the bottom or across part of the image appears the author’s name in a clean, sans-serif style: MICHAEL COLLINS. Some editions include a photograph of Collins in his spacesuit or a background image of a rocket launch, adding a human and aspirational touch.

1 1

Reposted by Aleyah E. Goins

Wonder of Science @wonderofscience.bsky.social · Jul 14

Colored droplets in corn syrup seemingly blended together can be returned to their original state by reversing the direction of mixing, a form of laminar flow called "Stokes flow".

Credit: UNM Physics & Astronomy

320 1K 6.1K

Aleyah E. Goins @goinsyeah.bsky.social · Jul 2

Cool! Happy hiring 🤩

Aleyah E. Goins @goinsyeah.bsky.social · Jul 2

Amazing score! Best of luck 😻

1

Reposted by Aleyah E. Goins

UoG Spinal Cord Group @spinalcordgroup.bsky.social · Jun 10

New preprint out now describing how macrophages can amplify spontaneous activity of damaged sensory neurons in a humanised in vitro model www.biorxiv.org/content/10.1...

Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain

Neuropathic pain is a highly prevalent condition for which treatments are hampered by low efficacy and dose-limiting side-effects. Injury to the somatosensory nervous system causes maladaptive plastic...

www.biorxiv.org

4 7

Reposted by Aleyah E. Goins

NYU Pain Research Center @nyupainresearch.bsky.social · May 27

A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....

Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross‐Sectional Observational Study

Background This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psycholo...

onlinelibrary.wiley.com

1 2 6