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Channelomics

@channelomics.bsky.social

450 followers 76 following 150 posts

Our Twitter feed lives on via an IFTTT rule, but this seems a nicer place. Ion channel stuff, papers, jobs, Studentship and if you are still active at a rig; sympathy! Anyone that’s done electrophysiology knows it is the ”sharp” end of science.

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Channelomics @channelomics.bsky.social · 42m

Delta-type glutamate receptors are ligand-gated #ionchannels |Nature
£$¥€

www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · 1d

TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures www.frontiersin.org/journals/pha...
#IonChannels

Channelomics @channelomics.bsky.social · 1d

Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · 1d

Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications

www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · 2d

A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42...
Open access

Channelomics @channelomics.bsky.social · 5d

TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Channelomics @channelomics.bsky.social · 6d

Twisting the Gate: How PIP2 Powers Kir #IonChannels

MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow.
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rupress.org/jgp/article/...

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating

Zangerl-Plessl et al. utilized MD simulations and revealed that PIP2 potentiated clockwise twisting motions in individual Kir2 channel cytoplasmic subunits

rupress.org

Channelomics @channelomics.bsky.social · Jun 13

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Channelomics @channelomics.bsky.social · Jun 10

ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814...

Channelomics @channelomics.bsky.social · Jun 8

Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/...

Channelomics @channelomics.bsky.social · Jun 7

Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic academic.oup.com/brain/advanc...

Raw ephys data. Lovely looking patch clamp whole cell.

Channelomics @channelomics.bsky.social · Jun 7

The molecular transition that confers voltage dependence to muscle contraction | Nature Communications www.nature.com/articles/s41...
#ionchannels

Channelomics @channelomics.bsky.social · Jun 6

The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable #ionchannel (never heard of it before) - Nature Communications www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · Jun 5

Identification of druggable binding sites and small molecules as modulators of TMC1 | Communications Biology

www.nature.com/articles/s42...

#ionchannels

Channelomics @channelomics.bsky.social · Jun 4

A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ #ionchannel KtrAB | Nature Communications

www.nature.com/articles/s41...

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Channelomics @channelomics.bsky.social · Apr 2

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature
#ionchannels

www.nature.com/articles/s41...

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Channelomics @channelomics.bsky.social · Apr 1

Nicotinic acetylcholine receptor #ionchannels regulate growth hormone in pituitary somatotrophs
…in tigers…

www.nature.com/articles/s42...

Reposted by Channelomics

Journal of General Physiology @jgp.org · Mar 19

Commentary: Lawrence Salkoff @washumedicine.bsky.social discusses new studies of potassium channel #evolution from the Jegla group (rupress.org/jgp/article/...) that contributes valuable insights into the evolution of complexity in electrical signaling. rupress.org/jgp/article/...
#IonChannels

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Reposted by Channelomics

Chai Ann Ng @chaiannng.bsky.social · Mar 20

Patch clamp #ionchannel assay for NaV1.5-Brugada Syndrome.
#SCN5A

Andrew Glazer @amglazer.bsky.social · Mar 20

🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]

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Reposted by Channelomics

Wei Wen🫩 @wwenneuro.bsky.social · Mar 20

Such a good feeling to get data again #patchclamp

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Channelomics @channelomics.bsky.social · Mar 19

Preferential allosteric modulation of Otop1 channels by small molecule compounds | Communications Biology
#ionchannels

www.nature.com/articles/s42...

Channelomics @channelomics.bsky.social · Mar 18

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications
#ionchannels

www.nature.com/articles/s41...

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Channelomics @channelomics.bsky.social · Mar 17

Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation | Cell Death & Disease
#ionchannels

www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · Mar 15

Ball-and-chain inactivation of a human large conductance calcium-activated potassium #ionchannels

www.nature.com/articles/s41...

Channelomics @channelomics.bsky.social · Mar 15

Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannels

www.nature.com/articles/s42...

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