Lightnews — Scholar-powered news

Reposted by Neel Shah

Euna Yoo @eunayoo.bsky.social · 9h

Our work on developing a fluorescent probe to measure granzyme B activity in anti-tumor immunity is finally out! pubs.acs.org/doi/10.1021/...

Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy

Molecular imaging of immune activation holds tremendous potential for the development of novel immunotherapies. In particular, chemical probes capable of detecting immune responses before changes in t...

pubs.acs.org

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Reposted by Neel Shah

ChemKritzer @chemkritzer.bsky.social · 2d

Come be my colleague! Tufts Chemistry is hiring a tenure-track Assistant Professor working on materials with energy applications. We have a fantastic, supportive environment for you to start your research career. Send questions to me or @chemysl.bsky.social

apply.interfolio.com/175284

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Reposted by Neel Shah

Prachee Avasthi @pracheeac.bsky.social · 4d

New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.

pracheeac.substack.com/p/scholarly-...

Scholarly Communication Is a Research Problem. This Means You.

Scholarly Communication Is a Research Problem.

pracheeac.substack.com

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Neel Shah @nshahlab.bsky.social · 8d

Excited to dig into this! Congrats to the whole team!

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Reposted by Neel Shah

Jason Zhang 🏳️‍🌈🇺🇸 @jasonzxzhang.bsky.social · 8d

Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.

Magnus Bauer @kinasekid.bsky.social · 8d

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

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Reposted by Neel Shah

Magnus Bauer @kinasekid.bsky.social · 8d

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

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Reposted by Neel Shah

José L. McFaline-Figueroa @jlmcfalinefigueroa.bsky.social · 9d

We’re hiring!📣

Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Neel Shah

Tina Perica @glukozica.bsky.social · 10d

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 12d

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

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Reposted by Neel Shah

Lorenz Lab @sonjalorenzlab.bsky.social · 14d

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity

Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

www.sciencedirect.com

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Reposted by Neel Shah

Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 15d

Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.

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Reposted by Neel Shah

Brittany S. Morgan @morganlabatnd.bsky.social · 28d

affinity, specificity, and selectivity as well as how targeting loops can allosterically alter protein activity.

We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)

University of Notre Dame hiring Postdoctoral Researcher in Notre Dame, IN | LinkedIn

Posted 1:31:15 AM. The STAR2 Lab (Selective Targeting Approaches for RNA and RNA-binding proteins) at the University…See this and similar jobs on LinkedIn.

lnkd.in

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Reposted by Neel Shah

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · Sep 5

Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.

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Reposted by Neel Shah

Lorenz Lab @sonjalorenzlab.bsky.social · Sep 2

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

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Reposted by Neel Shah

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · Aug 28

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.

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Reposted by Neel Shah

Alex Holehouse @alexholehouse.bsky.social · Aug 28

Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...

Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.

Asst Professor - Molecular Biology - Computational Biochemist

The Department of Molecular Biology (MOLB) and the School of Computing (SoC) at the University of Wyoming seeks candidates for a tenure-track position at the rank of Assistant Professor starting in th...

eeik.fa.us2.oraclecloud.com

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Reposted by Neel Shah

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Aug 27

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Sarafan ChEM-H @stanford-chemh.bsky.social · Aug 26

Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

Open Faculty Position: Assistant or Associate (Untenured) Professor

Application deadline: 11:55 PM on Wednesday, October 15, 2025

Sarafan ChEM-H is seeking candidates with research programs that exist at the interface between molecular science and computation.

Click the link above to learn more & apply!

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Reposted by Neel Shah

Sarafan ChEM-H @stanford-chemh.bsky.social · Aug 26

Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

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Reposted by Neel Shah

Jeff Martell @jeffmartell.bsky.social · Aug 28

Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social‬! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling

Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...

chemrxiv.org

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Reposted by Neel Shah

Nature @nature.com · Aug 27

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began

go.nature.com/3JyRV4S

How did life get multicellular? Five simple organisms could have the answer

Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.

go.nature.com

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Reposted by Neel Shah

Jeremy Baskin @jeremybaskin.bsky.social · Aug 25

Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs

Cornell University, Chemistry and Chemical Biology

Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US

academicjobsonline.org

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Reposted by Neel Shah

Chrystal Starbird @drstarbird.bsky.social · Aug 21

Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience.

I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾

Katie Wilkinson @drkwilkinson.bsky.social · Aug 21

Calling all @apsphysiology.bsky.social members: let’s help raise some money to support ABRCMS student presentation awards! Goal is $1200/discipline to support 12 awards by Sept 30th! 🧪 abrcms.org/donate/stude...

ABRCMS Fundraising - Student Presentation Awards - ABRCMS

Judges – Help Us Raise Funds for Student Presentation Awards Thank you for your service as a judge at ABRCMS. Your dedication has helped shape the future of countless student scientists, and we’re dee...

abrcms.org

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Neel Shah @nshahlab.bsky.social · Aug 18

Congrats to the whole team!

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Reposted by Neel Shah

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Neel Shah @nshahlab.bsky.social · Aug 14

Really awesome stuff! Congrats to the whole team!!

Jeff Martell @jeffmartell.bsky.social · Aug 14

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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DNA-Scaffolded Ultrahigh-Throughput Reaction Screening

Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...

chemrxiv.org

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Reposted by Neel Shah

Johannes Morstein @morstein.bsky.social · Aug 14

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social

pubs.acs.org/doi/10.1021/...

Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking

The lipid composition of cellular membranes is highly dynamic and undergoes continuous remodeling, affecting the biophysical properties critical to biological function. Here, we introduce an optical a...

pubs.acs.org

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