Lightnews — Scholar-powered news

Reposted by Tina Perica

Elizabeth Wood, PhD @lizbwood.bsky.social · 2d

For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Tina Perica @glukozica.bsky.social · 5d

It’s the chicken or the egg question. We are only now realising this layer is important because it was so hard to study. And because of that, people studying it probably didn’t do well in their careers

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Tina Perica @glukozica.bsky.social · 9d

Seems like they also listen to Ghost at Science!

Science Magazine @science.org · 9d

Last year, a special issue of Science explored the complex and close associations #rats share with humans—from their ubiquity in the human environment to their crucial role as biomedical models.

🐀 Learn more: https://scim.ag/46VBOrb #ScienceMagArchives

This photograph shows a female standard fancy rat—a domesticated variant for the pet trade.

Tina Perica @glukozica.bsky.social · 10d

😅

Tina Perica @glukozica.bsky.social · 10d

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 12d

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

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Snitty 🎃👻 @clofsnitville.bsky.social · 11d

In case you missed it: an essential piece from Olúfẹ́mi O. Táíwò from earlier this week:

www.bostonreview.net/articles/how...

How Can We Live Together? - Boston Review

Ezra Klein is wrong: shame is essential.

www.bostonreview.net

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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 12d

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

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Tina Perica @glukozica.bsky.social · Sep 8

Slightly diminish a book

Windy Heights

Dave Karpf @davekarpf.bsky.social · Sep 8

Slightly diminish a book

100 Days of Solitude

Sasha Costanza-Chock @schock.cc · Sep 8

Slightly diminish a book

The State and Nonviolent Civil Disobedience

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Reposted by Tina Perica

Colm Ryan @colmr.bsky.social · Aug 20

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ∼90,000 genetic interactions, in...

www.biorxiv.org

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Emily Hunt @emily.space · Aug 15

I also really dislike that talking about AI in this way by journalists - and discrediting humans who actually worked on a paper in the process - is basically free advertising for the AI industry.

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Emily Hunt @emily.space · Aug 15

ECRs who probably did the bulk of the work go completely unmentioned in the piece, in lieu of putting all credit on some anonymous and benevolent AI force that's probably just a few tens of millions of weights in a PyTorch model

AI designs new superbug-killing antibiotics for gonorrhoea and MRSA

Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.

www.bbc.com

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Emily Hunt @emily.space · Aug 15

I really dislike how science has started calling almost any fancy computational technique AI. 🧪

The framing of this entire article makes it sound like a benevolent AI independently made these drugs.

That is *pure fantasy*.

Instead: a team of scientists made a machine learning model for a study.

Article on BBC news.
Title: AI designs antibiotics for gonorrhoea and MRSA superbugs
Description: Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.

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Kevin Drew @ksdrew.bsky.social · Jul 29

We are excited to share our preprint describing DirectContacts2! Here we develop a machine learning model to discriminate between direct and indirect protein interactions. We use our model to construct a highly accurate wiring diagram of the human cell.

www.biorxiv.org/content/10.1...

DirectContacts2: A network of direct physical protein interactions derived from high-throughput mass spectrometry experiments

Cellular function is driven by the activity proteins in stable complexes. Protein complex assembly depends on the direct physical association of component proteins. Advances in macromolecular structur...

www.biorxiv.org

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Heidi Kitrosser @heidikitrosser.bsky.social · Jul 24

When you’re so busy crowing about your political motivations that you forget to pretend you did it for the Jews.

Aaron Rupar @atrupar.com · Jul 24

Linda McMahon on Columbia settlement: "This is a monumental victory for conservatives who wanted to do things on these elite campuses for a long time because we had such far left-leaning professors."

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MwahahahahahadScientist @mads100tist.bsky.social · Jun 29

These NPG spinoff journals are out of control

A picture of a bottle of hummus. It is labeled NATURE HUMMUS

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Tina Perica @glukozica.bsky.social · Apr 19

This. It’s such a no-brainer, really

Pedro Beltrao @pedrobeltrao.bsky.social · Apr 19

I think the ERC is 15-20% of the EU research and innovation budget. A lot of the other EU grants schemes are, in my opinion, going to large collaborative grants that aren't as efficient or doing as exciting research. Even making the ERC 50% of the research budget could make a great impact

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Tim Onion @bencollins.bsky.social · Apr 17

theonion.com/historians-q...

From The Onion:

Historians: Quibbling Over Exact Definition Of Concentration Camp Sign Of Healthy Society

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Kelly Nguyen @kellythd-nguyen.bsky.social · Apr 16

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 16

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs

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Zikang (Dennis) Huang @dennishuang.bsky.social · Apr 15

How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD
A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵

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jamelle @jamellebouie.net · Apr 15

DOGE is a criminal conspiracy to defraud the people of the United States

Josh Marshall @joshtpm.bsky.social · Apr 15

Oh dear you’re going to want to read this. Looks like DOGErs were caught exfiltrating NLRB data, likely on unions, for private (seemingly Elony) use. This is must read. What we’ve all suspected. But now details. www.npr.org/2025/04/15/n...

A whistleblower's disclosure details how DOGE may have taken sensitive labor data

A whistleblower tells Congress and NPR that DOGE may have taken sensitive labor data and hid its tracks. "None of that ... information should ever leave the agency," said a former NLRB official.

www.npr.org

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Tina Perica @glukozica.bsky.social · Apr 10

Not to worry, it will all trickle down to the poor racists!

Outspoken™️ @out5p0ken.bsky.social · Apr 10

“He made 2.5 million today and he made $900 million. That’s not bad.”

Sounds like market manipulation to me. That’s bad.

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Tina Perica @glukozica.bsky.social · Apr 1

🧵

Ian Dunt @iandunt.bsky.social · Mar 31

Putin comes against Le Pen ruling. Authoritarians hates any possibility of legal restraint on their leadership. Trump will doubtless do the same. Journalists do not have to follow this framing. There is zero reason for them to start a report by questioning whether the ruling is democratic.

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Tina Perica @glukozica.bsky.social · Mar 31

Us progressive women demonize her because we are jealous. You see, we leftists cannot cook dinner or talk to our children. It’s sad, really. It’s like, you either have a family and say hi to your neighbors, or you are against fascism. Can’t have both.

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NY Times Pitchbot @nytpitchbot.bsky.social · Mar 30

I just did a photo op at a US base in Greenland that I learned about last week. Here’s why we must destroy our alliances and hand over the Arctic to Russia.

by JD Vance

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Reposted by Tina Perica

Gillian Branstetter @gbbranstetter.bsky.social · Mar 27

The barrier is literally paper thin bsky.app/profile/reic...

Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · Mar 27

NEW! The Trump administration appears to have sent a married father with NO CRIMINAL RECORD in any country to rot in a prison in El Salvador because of a PAPERWORK ERROR.

This man doesn’t even have tattoos! But his paperwork has two different peoples’ ID numbers listed and the wrong last name!

The U.S. government claims on Reyes Mota's I-213 form, a document the Department of Homeland Security uses to support that someone is deportable, that he "may be a Tren de Aragua associate." But in those same documents, the government says he has no criminal records or immigration history in the United States. The government also uses someone else's last name in several parts of the document, identifies him with female pronouns, and uses two different unique identification numbers that immigration authorities use to keep track of individuals, raising questions about the reliability of Trump officials accusations against him.

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