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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

www.cell.com/cell-reports...

www.cell.com

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

www.cell.com/cell-reports...

www.cell.com

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

By mutating PERK’s copper-binding sites, researchers made cells & worms hypersensitive to stress. ➡️ Copper availability literally decides survival vs. death.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

Cells use metals like copper as molecular switches. Understanding this could open new ways to target stress responses in cancer, neurodegeneration & beyond.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

This is the latest addition to known cases of metallallosteric regulation of a protein kinase. Metal ions aren’t just cofactors — they’re signals that tune cell fate.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

Cells are constantly stressed by misfolded proteins. PERK is one of the cell’s “emergency brakes.” This study shows PERK only works if it has copper bound — no copper, no brake.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 15d

This award is not just mine. It reflects the efforts of so many who believe in equal opportunity and mentorship, & opportunity — & who have trusted, supported, & invested in my leadership along the way. @pennmedcso.bsky.social @penncbio.bsky.social @penncancer.bsky.social @rtaatpennmed.bsky.social

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 15d

www.pennmedicine.org/news/maximiz...

Maximizing access to science with Donita Brady, PhD | Penn Medicine

The 2026 recipient of the ASBMB Ruth Kirschstein Award for Maximizing Access in Science shares her approach to creating opportunities for all.

www.pennmedicine.org

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 15d

Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Aug 20

Congratulations to the Brady Lab!

Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Jul 2

🎉Brady Lab is 10! A decade of discovery & growth. This milestone belongs to the incredible trainees, collaborators, colleagues, & steadfast friends & family who’ve fueled our journey every step. On to the next chapter @pennmedicine.bsky.social @penncbio.bsky.social @rtaatpennmed.bsky.social 💙

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Sep 5

Join us in celebrating the #ASBMB26 Award Winners!
• @abu-remaileh.bsky.social
• Suzanne Barbour
• @bradylabupenn.bsky.social
• George Carman
• Joseph Cotruvo
• Roger Davis
• @rolanddunbrack.bsky.social
• Pamela Mertz
• @olzmannlab.bsky.social
• Kim Orth
• Margaret Phillips
ow.ly/x05f50WSbax

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

PennMedCSO @pennmedcso.bsky.social · 22d

Congratulations to @bradylabupenn.bsky.social (@penncbio.bsky.social/ @rtaatpennmed.bsky.social), recipient of the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science! tinyurl.com/6w7n3uzx

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Jul 2

🎉Brady Lab is 10! A decade of discovery & growth. This milestone belongs to the incredible trainees, collaborators, colleagues, & steadfast friends & family who’ve fueled our journey every step. On to the next chapter @pennmedicine.bsky.social @penncbio.bsky.social @rtaatpennmed.bsky.social 💙

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Jun 19

As Faculty Director of @rtaatpennmed.bsky.social, I’m proud to affirm our values that shape our education, training & outreach commitments. Juneteenth reminds us that progress is ongoing—and our work must be rooted in respect, access, & opportunity for all. #Juneteenth

Research Trainee Affairs at Penn Medicine @rtaatpennmed.bsky.social · Jun 19

Juneteenth is a story of freedom hard-won & resilience hard-kept—honoring Black history & the ongoing fight for justice. At Penn Medicine, Research Trainee Affairs advances discovery rooted in respect, access & opportunity—values that shape our comprehensive education, training & outreach mission.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · May 15

My buddy hard at work on his experiments! There’s nothing quite as pure as the excitement he feels learning through play.

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · May 11

Check out the first preprint from @drariav.bsky.social lab!

Aria Vaishnavi, PhD @drariav.bsky.social · May 9

I am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer.

www.biorxiv.org/content/10.1...

BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our u...

www.biorxiv.org

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

Johnson Lab - University of Iowa @campylobacterlab.bsky.social · May 9

Hey y'all! My department is conducting a search for an assistant or associate professor in bacteriology. It's pretty broadly defined. If you know anyone who's looking for a great department that does awesome science - please send them our way! You can DM me with any questions you have 😀

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · May 3

Proud to see ASBMB joining other scientific societies in support of the MOSAIC programs!

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · May 2

Earlier today, ASBMB joined three other scientific societies in leading a substantial, 22-page amicus curiae brief in support of the plaintiffs in American Public Health Association v. NIH. This is a formal public submission to the court.
➡️Read our full message: bit.ly/3RJnWbp.

Text reads: A message to ASBMB members. The background is an illustration of the neurotransmitter glutamate being transported by synaptic vesicles to the presynaptic membrane.

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

Fusion Conferences @fusionconf.bsky.social · Apr 29

#RedoxBio25 Announcement! 🚨
Exciting opportunity for early career researchers! 🎉We have complimentary registrations available!
Don't miss out - apply now! ➡️ bit.ly/4cSV0qZ

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

Fusion Conferences @fusionconf.bsky.social · Apr 29

Please help spread the word: @ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Apr 7

For the upcoming #ASBMB25 symposia on oncogenic hubs, organizers Cigall Kadoch and Greg Wang selected a diverse array of speakers who study the role of molecular condensates, extrachromosomal DNA, chromatin regulatory machinery, epigenetics and more in #cancer.
www.asbmb.org/asbmb-...

Unraveling oncogenesis: What makes cancer tick?

Learn about the ASBMB 2025 symposium on oncogenic hubs: chromatin regulatory and transcriptional complexes in cancer.

www.asbmb.org

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Reposted by Dr. Donita C. Brady of Brady Lab UPenn

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Apr 7

New #lipidmetabolism research is shedding light on crucial lipid–protein interactions, revealing promising therapeutic targets for both metabolic and neurodegenerative diseases. Discover the latest breakthroughs in lipid science at the ASBMB Annual Meeting: http://ow.ly/qUPE50V....

Exploring lipid metabolism: A journey through time and innovation

Recent lipid metabolism research has unveiled critical insights into lipid–protein interactions, offering potential therapeutic targets for metabolic and neurodegenerative diseases. Check out the latest in lipid science at the ASBMB annual meeting.

ow.ly

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Apr 6

Several months ago, I was honored to be invited by JMB Editor-in-Chief Mike Summers to write a Perspective for the Pioneers in Molecular Biology special issue. It was a chance to reflect on the journey that led me here. You can read the pieces here: tinyurl.com/2pb967u9 & tinyurl.com/kkwfynt2

Making Every Penny Count: Kinase Signaling Transduction, Copper Homeostasis, & Nutrient Sensing

I am the Harrison McCrea Dickson, MD, and Clifford C. Baker, MD Presidential Associate Professor of Cancer Biology at the University of Pennsylvania P…

tinyurl.com

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Apr 6

"Structural biology of proteins and subcellular structures" designed by Breann Brown & Christopher Barnes

"Synthetic biology" organized by Vatsan Raman & Danielle Tullman–Ercek.