Lightnews — Scholar-powered news

PMC Protein Modules Community @pmc-modularity.bsky.social · 23d

Tune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

2 3

PMC Protein Modules Community @pmc-modularity.bsky.social · Sep 5

Remember to tune in to our next Seminar on Monday September 8!

PMC Protein Modules Community @pmc-modularity.bsky.social · Aug 15

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

2 5

PMC Protein Modules Community @pmc-modularity.bsky.social · Aug 15

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

8 17

PMC Protein Modules Community @pmc-modularity.bsky.social · Jun 13

Remember to tune in next Monday (June 16) at 3pm CET. We’ll hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

3 1

PMC Protein Modules Community @pmc-modularity.bsky.social · Jun 6

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity
(2/2)

PMC Modularity

www.youtube.com

PMC Protein Modules Community @pmc-modularity.bsky.social · Jun 6

TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

(1/2)

1 4 3

PMC Protein Modules Community @pmc-modularity.bsky.social · May 9

Remember to tune it at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvarado-Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

2 3

PMC Protein Modules Community @pmc-modularity.bsky.social · Apr 24

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

We are currently reviewing the timing of the seminar series. If you have any thoughts, please fill out this form: forms.gle/xH9hLk5ZM994...
(2/2)

PMC Modularity

www.youtube.com

PMC Protein Modules Community @pmc-modularity.bsky.social · Apr 24

Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2
(1/2)

1 5 8

PMC Protein Modules Community @pmc-modularity.bsky.social · Apr 15

Thanks to everyone who has attended the PMC seminars!

We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxY...

Thanks for your input!

PMC Seminar feedback

Thank you for your interest in our seminar series! Whether you've been able to attend or were interested but unable to join us, we value your feedback. Your input will help us improve future sessions ...

forms.gle

1 2

PMC Protein Modules Community @pmc-modularity.bsky.social · Apr 11

Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

5 4

Reposted by PMC Protein Modules Community

Nature Chemical Biology @natchembio.nature.com · Jan 31

ARAF uniquely enhances RAS activity via its N-terminal disordered sequence, forming membrane ARAF-RAS condensates that shield RAS from negative regulation and drive cancer drug resistance

www.nature.com/articles/s41...

Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance - Nature Chemical Biology

ARAF uniquely enhances RAS activity via N-terminal disordered sequence, forming membrane ARAF–RAS condensates that shield RAS from negative regulation and drive cancer drug resistance.

www.nature.com

3 7

PMC Protein Modules Community @pmc-modularity.bsky.social · Mar 25

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!
(2/2)

PMC Modularity

www.youtube.com

PMC Protein Modules Community @pmc-modularity.bsky.social · Mar 25

Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar
(1/2)

1 5 4

Reposted by PMC Protein Modules Community

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Mar 12

Our review on machine learning methods to study sequence–ensemble–function relationships in disordered proteins is now out in COSB

authors.elsevier.com/sd/article/S...
Led by @sobuelow.bsky.social and Giulio Tesei

Figure from the paper illustrating sequence–ensemble–function relationships for disordered proteins. ML prediction (black) and design (orange) approaches are highlighted on the connecting arrows. Prediction of properties/functions from sequence (or vice versa, design) can include biophysics approaches via structural ensembles, or bioinformatics approaches via other hetero- geneous sources. The lower panels show examples of properties and functions of IDRs for predictions or design targets. ML, machine learning; IDRs, intrinsically disordered proteins and regions.

27 90

PMC Protein Modules Community @pmc-modularity.bsky.social · Mar 7

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!

(2/2)

PMC Modularity

www.youtube.com

PMC Protein Modules Community @pmc-modularity.bsky.social · Mar 7

Remember to join us at 6pm CET Mar 10 for the next seminar in our series with Dr. Dezső Módos (@imperialcollegeldn.bsky.social ) and Dr. Joanna Koszela (@uofglasgow.bsky.social ).

Register to attend: tinyurl.com/register-pmc-seminar

(1/2)

1

Reposted by PMC Protein Modules Community

Julia Rogers @juliarurogers.bsky.social · Feb 18

Enjoying #BPS2025! I'll present my development of a ML predictor of domain–peptide binding affinity to understand how affinity is optimized across the proteome for cell signaling. Finish out the meeting by coming to my talk tomorrow (Wed) @ 1pm!

1 3 24

PMC Protein Modules Community @pmc-modularity.bsky.social · Feb 13

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!

(2/2)

PMC Modularity

www.youtube.com

1 2

PMC Protein Modules Community @pmc-modularity.bsky.social · Feb 7

Remember to join us on Monday Feb 10 at 6pm CET for the first session of our online seminar series!

Register to attend: tinyurl.com/register-pmc-seminar

1

Reposted by PMC Protein Modules Community

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Feb 6

Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com

63 150

Reposted by PMC Protein Modules Community

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Nov 25

If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...

Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers:
Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US
Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH
Professor Ylva Ivarsson, Uppsala University, Sweden
Dr. Michael Wehr, Systasy Bioscience, Munich, Germany
Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary
Professor Kristian Strømgaard, HEALTH, UCPH
Professor Stefano Gianni, Sprienza University of Rome, Italy
Professor Per Jemth, Uppsala University, Sweden
Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark
Professor Benjamin Schuler, University of Zurich, Switzerland
Professor Alfonse De Simone, University of Naples, Italy
Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France
Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK
Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH

1 27 60

Reposted by PMC Protein Modules Community

EMBL-EBI @ebi.embl.org · Jan 27

Kinases play a role in many diseases, making them prime targets for therapeutic intervention.

Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.

Read the full article: academic.oup.com/bioinformati...

@alussana.bsky.social @epetsalaki.bsky.social

PhosX: data-driven kinase activity inference from phosphoproteomics experiments

AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru

academic.oup.com

1 14 21

Reposted by PMC Protein Modules Community

SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · Jan 27

Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/

18 26

PMC Protein Modules Community @pmc-modularity.bsky.social · Jan 15

Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne.

Register to attend: tinyurl.com/register-pmc-seminar

2 5