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ahellab.bsky.social @ahellab.bsky.social · 2d

This News & Views article provides a nice overview of the recent discoveries that RNF114 recognizes a dual modification ADP-ribose–ubiquitin (ADPr-Ub) and subsequently extends it by adding additional ubiquitin units.:
pubmed.ncbi.nlm.nih.gov/41039156/

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Reposted

The EMBO Journal @embojournal.org · 2d

RNF114 and RNF166 exemplify a new E3 ligases family that recognizes #MARUbylation –hybrid ADP-ribose/ubiquitin modifications– and extends them with K11-linked polyubiquitin
@jnpruneda.bsky.social @michaelnadbio.bsky.social and colleagues
www.embopress.org/doi/full/10....

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Reposted

dimitristypas.bsky.social @dimitristypas.bsky.social · 21d

The September @natsmb.nature.com issue is out! www.nature.com/articles/s41...
We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.

Focus on ubiquitylation and protein degradation - Nature Structural & Molecular Biology

We highlight primary research and commissioned content that delve into the biology of ubiquitylation and degradation mechanisms.

www.nature.com

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Reposted

Nature Biotechnology @natbiotech.nature.com · Sep 4

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - @helmholtz-hiri.bsky.social go.nature.com/4n7zDpG

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature Biotechnology

Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.

go.nature.com

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Reposted

The Dunn School, Oxford @dunnschool.bsky.social · Sep 8

Our PhD studentship programme is officially open; pass it on

If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...

Great science and a great environment!

www.path.ox.ac.uk/news-article...

Applications now open for our PhD studentship programme - Dunn School

Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

www.path.ox.ac.uk

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ahellab.bsky.social @ahellab.bsky.social · Sep 8

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
rdcu.be/eETIT

The rise of ADP-ribose–ubiquitin

Nature Structural & Molecular Biology - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational...

rdcu.be

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ahellab.bsky.social @ahellab.bsky.social · Sep 6

We have postdoc positions available to study roles of ADP-ribosylation and ubiquitination signalling in genome stability, infection or immunity. Please enquire if you are interested.

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The Dunn School, Oxford @dunnschool.bsky.social · Jul 30

📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...

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Alessandro Costa @costalaboratory.bsky.social · Jul 21

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoctoral Fellow - Costa Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

crick.wd3.myworkdayjobs.com

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ahellab.bsky.social @ahellab.bsky.social · Jul 18

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
my.corehr.com/pls/uoxrecru...

'

my.corehr.com

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Reposted

Rob Klose @robklose.bsky.social · Jul 15

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)

Colin Kleanthous' fundraiser for Motor Neurone Disease Association

Help Colin Kleanthous raise money to support Motor Neurone Disease Association

www.justgiving.com

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ahellab.bsky.social @ahellab.bsky.social · Jul 14

Defence island in Escherichia coli composed of DarTG toxin-antitoxin system embedded within a Type I restriction-modification system is regulated by the RptR (RMS-proximal transcriptional regulator).
academic.oup.com/nar/article/...

Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modification systems in diverse bacteria

Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th

academic.oup.com

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ahellab.bsky.social @ahellab.bsky.social · Jul 10

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

www.nature.com

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ahellab.bsky.social @ahellab.bsky.social · Jun 29

Our review article 'PARPs and ADP-ribosyl hydrolases in cancer therapy: from drug targets to biomarkers' is now available online.
doi.org/10.1016/j.dn...

Redirecting

doi.org

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ahellab.bsky.social @ahellab.bsky.social · Jun 29

We have a postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability and/or immunity. Expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

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my.corehr.com

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Reposted

Andrii Gorelik @andriigorelik.bsky.social · Jun 11

New paper! We uncover mechanistic insights into the crosstalk between AHR (aryl hydrocarbon receptor, a transcription factor) and PARP7 (a nuclear enzyme that performs protein ADP-ribosylation). Both are promising cancer drug targets.

Big thanks to all co-authors!

www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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ahellab.bsky.social @ahellab.bsky.social · Jun 12

Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS

PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell g...

www.pnas.org

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ahellab.bsky.social @ahellab.bsky.social · Jun 6

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

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my.corehr.com

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ahellab.bsky.social @ahellab.bsky.social · Jun 5

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.

my.corehr.com/pls/uoxrecru...

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my.corehr.com

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Reposted

Kat Toropova @kattoropova.bsky.social · May 28

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford.

We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport.

❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬

30/5/25 ➡️ tinyurl.com/KToropovaPDRA

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Reposted

SP@RTE @spartelab.bsky.social · May 27

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

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Reposted

Juraj Ahel @juraj-ahel.bsky.social · May 22

Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...!

Many thanks to all the groups involved:
@clausenlab.bsky.social
@e3chembio.bsky.social
@fletcherlab.bsky.social

Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:

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ahellab.bsky.social @ahellab.bsky.social · May 24

This new paper in collaboration with the lab of Gerbrand van der Heden van Noort is a natural follow-up describing a ADPr-Ub reader protein: www.biorxiv.org/content/10.1...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Crosstalk between the post-translational modification processes ubiquitination and ADP-ribosylation occurs in DNA-damage and immune-responses, in addition the physical linkage of ADP-ribose and ubiqui...

www.biorxiv.org

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ahellab.bsky.social @ahellab.bsky.social · May 24

A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub):
pubmed.ncbi.nlm.nih.gov/36197986/

| bioRxiv

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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ahellab.bsky.social @ahellab.bsky.social · May 24

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...

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my.corehr.com

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